AI and tissue clearing-based technologies for health. Director at Helmholtz Munich, Full professor at LMU Munich, and CEO of Deep Piction (@deeppiction.bsky.social) We’re🇩🇪🇹🇷🇭🇷🇨🇳🇮🇹🇮🇳🇸🇮🇴🇲🇨🇱🇭🇺🇧🇬🇺🇦🇷🇴🇦🇹🇹🇼🏳‍🌈https://bsky.app/profile/erturklab.bsky.socialhttps://bsky.app/profile/erturklab.bsky.social/post/3mo6ke6l5is2cSee our science at Deep Piction, how we use it to develop new precision medicine. [contains quote post or other embedded content]13 Jun 2026 15:16 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mo6ke6l5is2chttps://bsky.app/profile/erturklab.bsky.social/post/3mmvw6usa6k27Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. Paper->> https://www.nature.com/articles/s41586-026-10535-2 Next https://www.biorxiv.org/content/10.64898/2025.12.10.693352v1.full.pdf28 May 2026 11:29 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mmvw6usa6k27https://bsky.app/profile/erturklab.bsky.social/post/3mmcq4lmar22gToday in Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. https://www.nature.com/articles/s41586-026-10535-2 More at: https://x.com/erturklab/status/2057118078991786072?s=2020 May 2026 20:19 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mmcq4lmar22ghttps://bsky.app/profile/erturklab.bsky.social/post/3mlvhdkli422p🧠 Does brain aging always mean vessel loss? We found the opposite in some aged brains: maladaptive hypervascularization, linked to cognitive decline and blood-brain barrier damage. Check it out below! https://www.biorxiv.org/content/10.64898/2026.05.04.720441v1.full.pdf15 May 2026 13:38 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mlvhdkli422phttps://bsky.app/profile/erturklab.bsky.social/post/3mlpsf5b6rk2xhappy to share our new protocol paper on wildDISCO for whole-body immunolabeling, tissue clearing & 3D imaging of intact mice at cellular resolution using standard IgG antibodies, for mapping of neuronal, vascular, lymphatic and immune systems across the entire body. https://www.nature.com/articles/s41596-026-01363-913 May 2026 07:39 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mlpsf5b6rk2xhttps://bsky.app/profile/erturklab.bsky.social/post/3mi4skotowk2rOne thing nobody teaches you in academia: 𝗵𝗼𝘄 𝘁𝗼 𝗻𝗲𝗴𝗼𝘁𝗶𝗮𝘁𝗲. We spend 10+ years learning how to do science, write grants, and present data. But when the job offer finally comes, most people just… accept it. Because we're relieved. Because we think the salary is fixed.28 Mar 2026 14:06 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mi4skotowk2rhttps://bsky.app/profile/erturklab.bsky.social/post/3mhdm64qcac2vUsing vDISCO tissue clearing, and a new ultrabright chemical labeling strategy. This work introduces LINCS for rapid, scalable 3D connectivity mapping from single neurons to whole brains, advances for high-throughput circuit mapping. Great work by Rui Lin lab. https://www.sciencedirect.com/science/article/pii/S0896627325006579?via%3Dihub18 Mar 2026 13:35 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mhdm64qcac2vhttps://bsky.app/profile/erturklab.bsky.social/post/3mgmtjd4kcs2vHiring in Munich: Staff Scientist / Postdoc in Tissue Clearing and 3D Image Analysis. We’re looking for someone with strong hands-on expertise in tissue clearing, light-sheet microscopy, and quantitative 3D image analysis. Shares and recommendations are very welcome. https://www.linkedin.com/jobs/view/4381294607/ https://linkedin.com/jobs/view/4381294607/09 Mar 2026 12:16 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mgmtjd4kcs2vhttps://bsky.app/profile/erturklab.bsky.social/post/3meqcnyo6zk2kIn this recent Nature Methods Perspective, I outline how tissue clearing, spatial-omics, and AI converge to create deep 3D histology, enabling unbiased, organism-scale biology and next-generation digital pathology. https://www.nature.com/articles/s41592-024-02327-113 Feb 2026 10:34 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3meqcnyo6zk2khttps://bsky.app/profile/erturklab.bsky.social/post/3meeouuhsqc2sA new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams. https://www.biorxiv.org/content/10.1101/2025.05.21.655358v108 Feb 2026 19:41 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3meeouuhsqc2shttps://bsky.app/profile/erturklab.bsky.social/post/3mcdgn3ue222iWe’re hiring – Computer Science PhD at iBIO (Helmholtz Munich / LMU). Build AI-driven, whole-body multi-omics atlases by combining scRNA-seq, spatial transcriptomics, proteomics & 3D imaging. Looking for strong omics data analysis skills with ML/DL. Apply or share: https://www.linkedin.com/jobs/view/435300070013 Jan 2026 20:50 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mcdgn3ue222ihttps://bsky.app/profile/erturklab.bsky.social/post/3mb5ikdjxzs23My team at Deep Piction (Munich) is hiring a Senior Director, Drug Discovery (Long Covid) to build and lead our early discovery engine. If you have 10+ years in early-stage biotech/pharma, let’s talk. https://www.linkedin.com/jobs/view/435078121529 Dec 2025 18:44 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mb5ikdjxzs23https://bsky.app/profile/erturklab.bsky.social/post/3mabfzsvzgs2xMost transcriptomics studies sample ~0.001% of a mouse. Which region do we choose? Often: we guess. Meet DISCO-seq 🤗 flipping the order: RNA-preserving clearing → whole-organ/whole-body 3D imaging → pick ROIs in 3D → unbiased scRNA-seq. Preprint: https://www.biorxiv.org/content/10.64898/2025.12.10.693352v1.full.pdf18 Dec 2025 14:44 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mabfzsvzgs2xhttps://bsky.app/profile/erturklab.bsky.social/post/3mabfzsvzgs2xMost transcriptomics studies sample ~0.001% of a mouse. Which region do we choose? Often: we guess. Meet DISCO-seq 🤗 flipping the order: RNA-preserving clearing → whole-organ/whole-body 3D imaging → pick ROIs in 3D → unbiased scRNA-seq. Preprint: https://www.biorxiv.org/content/10.64898/2025.12.10.693352v1.full.pdf18 Dec 2025 14:44 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mabfzsvzgs2xhttps://bsky.app/profile/erturklab.bsky.social/post/3m7ia5ztsjk2oCongratulations to our scientist, Laurent Simons, for earning his PhD in quantum physics at just 15—an exceptional achievement. In our lab, Laurent’s work focuses on in silico biology to accelerate treatment of devastating diseases. We’re thrilled to have him on the team.08 Dec 2025 14:22 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3m7ia5ztsjk2o