AI and tissue clearing-based technologies for health. Director at Helmholtz Munich, Full professor at LMU Munich, and CEO of Deep Piction (@deeppiction.bsky.social) We’re🇩🇪🇹🇷🇭🇷🇨🇳🇮🇹🇮🇳🇸🇮🇴🇲🇨🇱🇭🇺🇧🇬🇺🇦🇷🇴🇦🇹🇹🇼🏳‍🌈https://bsky.app/profile/erturklab.bsky.socialhttps://bsky.app/profile/erturklab.bsky.social/post/3mznp3oxkmn2uUsing DISCO clearing, a recent Nature paper investigates why prior adversity makes the next stressor hit harder.06 Nov 2026 15:28 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mznp3oxkmn2uhttps://bsky.app/profile/erturklab.bsky.social/post/3mzms5rjfp72tDoes communication in your international lab keep switching away from English? Be alert. Someone may be getting excluded. We say we embrace international scientists and want everyone to feel welcome.06 Nov 2026 06:50 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mzms5rjfp72thttps://bsky.app/profile/erturklab.bsky.social/post/3mzix4a7hmk24Was Alzheimer's genetic risk underestimated? Nearly threefold 🧬 127 loci (48 new), SNP heritability 16%, and risk converging on microglia and neurons. Congrats to Uffelmann, Posthuma and the PGC-ALZ team in Nature 👇🏻 https://doi.org/10.1038/s41586-026-11206-y04 Nov 2026 18:08 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mzix4a7hmk24https://bsky.app/profile/erturklab.bsky.social/post/3mzikohksfc2wHow does APOE4 damage brain blood vessels? Pericytes turn into fibronectin-secreting myofibroblasts that promote vascular amyloid, driven by TGF-β. Blocking TGF-β restored pericytes. Congrats to the Blanchard lab in Cell 👇🏻 https://doi.org/10.1016/j.cell.2026.08.05804 Nov 2026 14:26 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mzikohksfc2whttps://bsky.app/profile/erturklab.bsky.social/post/3mzgfq7jxpv2oCan lipids alone map the brain? 🧠 A micrometre-scale lipid atlas of the mouse brain reveals 'lipizones' that align with functional anatomy, and lipid remodelling in pregnancy. Congrats to the La Manno lab in Nature 👇🏻 https://doi.org/10.1038/s41586-026-11050-003 Nov 2026 17:52 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mzgfq7jxpv2ohttps://bsky.app/profile/erturklab.bsky.social/post/3mzg2kbf7pi2xIs the skull's bone marrow different from other bones? Yes, it is the most distinct 🧠 In Cell, using SHANEL and vDISCO clearing, we showed skull marrow mirrors brain inflammation on TSPO-PET in patients with neurological disorders 👇🏻 https://doi.org/10.1016/j.cell.2023.07.00903 Nov 2026 14:32 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mzg2kbf7pi2xhttps://bsky.app/profile/erturklab.bsky.social/post/3mzdugoljnh2aIf nobody in your lab disagrees with you, I would be worried. A PhD student may see a problem you missed. The test is how you react: take the objection seriously, and when they're right, say so in front of the team. I want to train scientists who develop better ideas than mine.02 Nov 2026 17:37 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mzdugoljnh2ahttps://bsky.app/profile/erturklab.bsky.social/post/3mzdkzytwjf2tWhat does obesity do to nerves across the whole body? 🧠 With MouseMapper, our deep-learning suite, we mapped nerves and immune cells in vDISCO-cleared mice (31 organs) and found damaged infraorbital nerves with whisker-sensing deficits. In Nature 👇🏻 https://doi.org/10.1038/s41586-026-10535-202 Nov 2026 14:49 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mzdkzytwjf2thttps://bsky.app/profile/erturklab.bsky.social/post/3mycwkkmjss2nWe recently introduced LipiGO 🤩: targeted mRNA delivery beyond the liver 🧬 A step toward cell-level precision in medicine: drastically enhanced immune-cell targeting for future in vivo therapies, including CAR-T. https://biorxiv.org/content/10.1101/2025.09.15.676334v220 Oct 2026 15:17 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mycwkkmjss2nhttps://bsky.app/profile/erturklab.bsky.social/post/3mxrftmv4h223We recently introduced DISCO-seq 🤩: scRNA-seq after tissue clearing 🧬 https://www.biorxiv.org/content/10.64898/2025.12.10.693352v1 Image whole organs or bodies in 3D at cellular resolution. Select regions for unbiased scRNA-seq. From glioblastoma to whole-body SARS-CoV-2 S1 mapping 👇🏻 #DISCOseq13 Oct 2026 16:03 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mxrftmv4h223https://bsky.app/profile/erturklab.bsky.social/post/3mru4pti62k2bSARS-CoV-2 spike protein accumulates & persists in the body for years👇🏻. We develop advanced imaging/AI to cure Long COVID & beyond👇🏻. Join us 🤗 https://www.nature.com/articles/s41586-026-10535-2 https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00438-4 https://www.biorxiv.org/content/10.64898/2025.12.10.693352v1 https://www.biorxiv.org/content/10.64898/2026.05.04.720441v1 https://www.biorxiv.org/content/10.1101/2025.09.15.676334v230 Jul 2026 09:26 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mru4pti62k2bhttps://bsky.app/profile/erturklab.bsky.social/post/3mrpmxd6ivc2jBrain vascular aging isn’t a single path. Our new work shows that the aging brain diverges into two states: 🧠 Hypovascular (expected) 🧠 Hypervascular (surprising), with BBB leakage, inflammation and cognitive decline. Our study👇🏻: https://www.biorxiv.org/content/10.64898/2026.05.04.720441v128 Jul 2026 14:33 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mrpmxd6ivc2jhttps://bsky.app/profile/erturklab.bsky.social/post/3mo6ke6l5is2cSee our science at Deep Piction, how we use it to develop new precision medicine. [contains quote post or other embedded content]13 Jun 2026 15:16 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mo6ke6l5is2chttps://bsky.app/profile/erturklab.bsky.social/post/3mmvw6usa6k27Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. Paper->> https://www.nature.com/articles/s41586-026-10535-2 Next https://www.biorxiv.org/content/10.64898/2025.12.10.693352v1.full.pdf28 May 2026 11:29 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mmvw6usa6k27https://bsky.app/profile/erturklab.bsky.social/post/3mmcq4lmar22gToday in Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. https://www.nature.com/articles/s41586-026-10535-2 More at: https://x.com/erturklab/status/2057118078991786072?s=2020 May 2026 20:19 +0000at://did:plc:ipveryj5epjac3cftblstca7/app.bsky.feed.post/3mmcq4lmar22g