In-depth analysis of research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Formerly known as ME/CFS Skeptic. https://mecfsscience.org/https://bsky.app/profile/mecfsscience.orghttps://bsky.app/profile/mecfsscience.org/post/3mz5w6rxfok2g1) We’ve written a new article about the spectacular progress in artificial intelligence (AI), the billions that AI companies are investing to transform drug discovery, and why this is a reason for hope for ME/CFS patients. Here's a brief summary 👇 https://mecfsscience.org/the-ai-revolution/31 Oct 2026 08:52 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mz5w6rxfok2ghttps://bsky.app/profile/mecfsscience.org/post/3myyww7s3h42v1) It's been a while since we heard from the microclot theory. This new paper from Oxford says it found no evidence of hypercoagulability, altered fibrinolysis, or increased microclots. Important caveat: it used frozen samples and a different technique to measure clots. 29 Oct 2026 09:22 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3myyww7s3h42vhttps://bsky.app/profile/mecfsscience.org/post/3myuao7hev22uThere are several other trials on low-dose naletrexone (LDN) by: - Marshall-Gradisnik at Griffith University, Australia - Yarred Younger at University of Alabama, USA https://clinicaltrials.gov/study/NCT07285473 - David Systrom at Brigham and Women's Hospital, USA https://www.omf.ngo/the-life-improvement-trial/ [contains quote post or other embedded content]27 Oct 2026 12:33 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3myuao7hev22uhttps://bsky.app/profile/mecfsscience.org/post/3mytubpmh622z1) 🇨🇦 The results of Luis Nacul's trial of low-dose naltrexone (LDN) have been published. Unfortunately, it shows that LDN didn't improve fatigue, pain and other symptoms in patients who developed ME/CFS after COVID-19. A brief breakdown of the main results. 👇 27 Oct 2026 08:52 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mytubpmh622zhttps://bsky.app/profile/mecfsscience.org/post/3myrcnqbx7d2x1) There's a new critical review of patient-reported outcome measures in ME/CFS and Long Covid. The paper argues that trials often fail to include important symptom domains such as post-exertional malaise, dysautonomia and mast cell activation symptoms. 26 Oct 2026 08:31 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3myrcnqbx7d2xhttps://bsky.app/profile/mecfsscience.org/post/3mymanpdg3k2wAlways great to see the ME/CFS field growing and attracting new talents. [contains quote post or other embedded content]24 Oct 2026 08:12 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mymanpdg3k2whttps://bsky.app/profile/mecfsscience.org/post/3mymancnbyk2w1) 🇦🇹 Matthias Wielscher's group is recruiting two fully funded PhD candidates to work on ME/CFS through the Medical University of Vienna’s international PhD programme. The two projects have a shared goal: understanding the biological and clinical heterogeneity of ME/CFS.24 Oct 2026 08:11 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mymancnbyk2whttps://bsky.app/profile/mecfsscience.org/post/3mycf6646i22fThere's a big new paper on Long Covid, showing activated T-cells consistent with viral persistence (e.g., in the gut). We wrote a brief summary and some comments in the thread below. [contains quote post or other embedded content]20 Oct 2026 10:06 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mycf6646i22fhttps://bsky.app/profile/mecfsscience.org/post/3mycasbuog22w1) Researchers discovered a subgroup of Long Covid patients with more activated killer T cells targeting SARS-CoV-2 spike and proteins from the Epstein–Barr virus (EBV). A brief breakdown of the main findings 👇20 Oct 2026 08:48 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mycasbuog22whttps://bsky.app/profile/mecfsscience.org/post/3my7pj6rra3241) Just watched the presentation by Dr. Hanna Ollila titled "The Future of MECFS Genetics". Her team did the fibromyalgia genetic study and her background is in sleep genetics and brain autoimmunity. She gave a good impression and presented findings from a big meta-analysis. 19 Oct 2026 08:33 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3my7pj6rra324https://bsky.app/profile/mecfsscience.org/post/3my54a5eqnb2f1) News from Solve ME: The CDC plans to shorten the National Health Interview Survey (NHIS) so that it no longer includes questions about ME/CFS and Long Covid. The NHIS has previously been used to estimate ME/CFS prevalence at 1.3% 18 Oct 2026 07:43 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3my54a5eqnb2fhttps://bsky.app/profile/mecfsscience.org/post/3my2lr73e5y251) A survey of 6607 patients with autoimmune diseases found that women were more likely than males to report that their autoimmune disease had been attributed to psychiatric (43.3% vs. 32.7%) and psychosomatic causes (33.9% vs. 21.5%). 17 Oct 2026 07:43 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3my2lr73e5y25https://bsky.app/profile/mecfsscience.org/post/3mxy4ephmlr2m1) 🇳🇱 Good news: Felipe Correa da Silva, the researcher leading the brain tissue analysis in ME/CFS, announced that he won a new Dutch grant called "Off Road." It is intended for curiosity-driven, high risk, high reward ideas and provides up to €100.000 in funding. 16 Oct 2026 08:02 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mxy4ephmlr2mhttps://bsky.app/profile/mecfsscience.org/post/3mxvjooahud2f1) Data from five German university hospitals shows that the DSQ-PEM for post-exertional malaise scaled with fatigue and overall symptom burden. Although CFS and Long Covid patients scored the highest, patients with chronic pain, cancer and MS also had increased scores. 15 Oct 2026 07:22 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mxvjooahud2fhttps://bsky.app/profile/mecfsscience.org/post/3mxt2hnggfu2a1) 🇫🇷 France' public health insurance Ameli has updated its info on ME/CFS including sections critical of graded exercise and CBT. In this article, however, proponents of psychosomatic medicine explain how they pushed back to get some of the language changed. 14 Oct 2026 07:44 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mxt2hnggfu2ahttps://bsky.app/profile/mecfsscience.org/post/3mxqn5oo5kg2f1) 🇺🇸 Leonard Jason announced that his team has received an NIH award for the study "SARS-CoV-2 and EBV-orchestrated activation of the kynurenine pathway." 13 Oct 2026 08:41 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mxqn5oo5kg2fhttps://bsky.app/profile/mecfsscience.org/post/3mxnyoqwojc251) 🧬 We did a new genetic analysis using DecodeME. We leveraged a database on chromatin openness in the human brain. More openness means DNA is accessible and potentially active in various cell types. The graph below shows the results for ME/CFS and various other diseases. 12 Oct 2026 07:29 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mxnyoqwojc25https://bsky.app/profile/mecfsscience.org/post/3mxll653kz2251 🇳🇴) In this Norwegian study, therapists using a psychosomatic approach to ME/CFS expressed "concern about how current approaches might be viewed if future research were to establish a treatable biological dysfunction." 11 Oct 2026 08:22 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mxll653kz225https://bsky.app/profile/mecfsscience.org/post/3mxj23gicfm2x1) 🇩🇪 The German Society for ME/CFS (Deutsche Gesellschaft für ME/CFS) has its own small research program to fund smaller exploratory studies. €30,000 is awarded each year. Only researchers affiliated with an institution in Germany can apply. Deadline: 15 november. 10 Oct 2026 08:11 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mxj23gicfm2xhttps://bsky.app/profile/mecfsscience.org/post/3mxbfuiiqmn2r1) 🔬 New funding opportunity for ME/CFS research! Solve is now accepting submissions for their Ramsay Research Grant Program! Funding is between $50.000 - $150.000 depending on the category. The deadline to apply is Friday, November 13, 2026. 07 Oct 2026 07:20 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mxbfuiiqmn2rhttps://bsky.app/profile/mecfsscience.org/post/3mx6vfw6m462r1) "... the medical aspects of the illness are on the whole better understood by sick people than by their doctors..." In this new paper, philosopher Chloé De Canson details how the ME/CFS community shares and produces scientific knowledge. 06 Oct 2026 07:21 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mx6vfw6m462rhttps://bsky.app/profile/mecfsscience.org/post/3mwnecseiip2j1) An initiative worth sharing: The Severe & Very Severe ME Research Registry. It's a website that provides access to research for severely and severely affected ME/CFS patients from Germany, Austria and Switzerland (DACH region). 29 Sep 2026 07:59 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mwnecseiip2jhttps://bsky.app/profile/mecfsscience.org/post/3mvwoebushw2c1) The team of Andreas Goebel was the first to transfer autoantibodies of fibromyalgia patients to mice (similar studies later followed in Long Covid). In this paper, they tested rozanolixizumas: a drug that lowers circulating antibody levels. A brief summary of the results 👇 20 Sep 2026 07:28 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mvwoebushw2chttps://bsky.app/profile/mecfsscience.org/post/3mvrnozytof241) A genetic analysis of the UK Biobank found 7 ME/CFS hits that were replicated in another cohort such as the All of Us cohort. One signal matched with expression of the gene CLYBL in the putamen brain region. But there are many caveats. None replicated in DecodeME. 18 Sep 2026 07:33 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mvrnozytof24https://bsky.app/profile/mecfsscience.org/post/3mvpaf6hxjp2e1) The pharma company BioVie announced the results of the phase 2 trial of their drug Bezisterim for Long Covid. Although the primary analysis showed no significant effect, an analysis in subgroups with a great symptom burden suggested an improvement. A brief breakdown 👇 17 Sep 2026 08:29 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mvpaf6hxjp2ehttps://bsky.app/profile/mecfsscience.org/post/3mvhlhmircj241) There's a new consensus statement on ME/CFS diagnosis and assessment by 19 experts. The table below shows some of the objective tests they recommend for various symptom domains including a standing test, polysomnography, actigraphy, CPET, NK cytotoxicity, etc. 14 Sep 2026 07:26 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mvhlhmircj24https://bsky.app/profile/mecfsscience.org/post/3mvaagrsway2z1) This study found that ME/CFS patients often have too low blood and low red blood cell volume. But surprisingly, these measures weren't related to orthostatic intolerance as measured by a lean test. This suggest that hypovolemia isn't the main reason for orthostatic problems. 11 Sep 2026 09:20 +0000at://did:plc:ith7dzcppw7ru2enoauywkld/app.bsky.feed.post/3mvaagrsway2z