Microbiologist | Biochemist | Structural Biologist, Lausanne 🇨🇭 | Studying molecular machines (SMC, ParB, Wadjet, Lamassu & more) in Genome Integrity & Nucleic Acid Immunity. 🔬 Lab homepage: wp.unil.ch/gruberlabhttps://bsky.app/profile/gruberlab.bsky.socialhttps://bsky.app/profile/gruberlab.bsky.social/post/3mid6hz3nbc2xLast day to register for the SMC meeting 2026! [contains quote post or other embedded content]31 Mar 2026 02:56 +0000at://did:plc:itmpgj37r6dh4o7m43zobzcw/app.bsky.feed.post/3mid6hz3nbc2xhttps://bsky.app/profile/gruberlab.bsky.social/post/3m6hnn2iy7k2bThe hinge bypass gate paper is finally out! https://doi.org/10.1038/s41467-025-65408-5 We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA — including transcription machinery & potentially other SMCs. A lucky convergence of 3 projects lead to the initial discovery!25 Nov 2025 15:26 +0000at://did:plc:itmpgj37r6dh4o7m43zobzcw/app.bsky.feed.post/3m6hnn2iy7k2b