Sometimes tweeting about T cells, Vaccines, Viruses, TCRs, Immunogen Design, AI, Viral Seq Evolution... PI: Leo Swadling @IIT_UCL 🍐 www.researchgate.net/profile/Leo-Swadling profiles.ucl.ac.uk/61477-leo-swadlinghttps://bsky.app/profile/tcellvaccineucl.bsky.socialhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3m6epnkzoms2wOne week until the Swadling Lab heads to #BSI25! We have 4 members presenting this year — 3 posters + 1 talk — covering T cell responses, SARS-CoV-2, and vaccine design. Come find us and say hello! #vaccines #immunology #Tcells #virus24 Nov 2025 11:24 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3m6epnkzoms2whttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3m5tjheixpk2t🚨Preprint🚨: To better utilise the potential for cross-protective T cells in HPV vaccines we would like to take a rational approach to designing T-cell inducing HPV vaccines (prophylactic and therapeutic) ⚔️ https://www.medrxiv.org/content/10.1101/2025.11.03.25339381v117 Nov 2025 15:18 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3m5tjheixpk2thttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3m3wkmfwafs2gEver heard of this #vaccination side effect? SARS-CoV-2 mRNA vaccination significantly increased anti tumour responses and survival in patients with metastatic melanoma and NSCLC undergoing treatment with ICIs. https://www.nature.com/articles/s41586-025-09655-y #vaccineswork #tcells #immunology24 Oct 2025 09:26 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3m3wkmfwafs2ghttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lt2ly2ae2k2mAn HA/NP/IL-1B adenovirus led to a different profile of lung-resident Trms than natural H1N1 infection with the adjuvanted vaccine leading to longer lived lung-resident Trms than infection. https://pmc.ncbi.nlm.nih.gov/articles/PMC12003732/ #immunology #vaccine #Tcell #memory03 Jul 2025 11:14 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lt2ly2ae2k2mhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lrxtn637qc2z5 charts that show #vaccineswork https://www.nature.com/articles/d41586-025-00862-119 Jun 2025 15:28 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lrxtn637qc2zhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lruoqfw7vc23Another nice study illustrating that targeting responses to the nasal mucosa could be superior to systemic administration. The CAF09b adjuvant plus recombinant protein in an i.n. vaccine induced better nasal IgA and CD8 responses than i.m. mRNA.18 Jun 2025 09:22 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lruoqfw7vc23https://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lrs57ybc4c2mCool to see this upcoming phase 2 clinical trial for aerosolised vaccine formulations, with planned measurements of lung T cell responses https://publications.ersnet.org/content/erjor/11/3/00758-2024 #clinicaltrial #tcell #vaccineswork #immunology #vaccine17 Jun 2025 09:04 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lrs57ybc4c2mhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lrprzislgs2zNew interesting data on the role of T cells in Ad26-COV2.S-mediated immunity to SARS-CoV-2! Back in 2021, a phase 3 study showed that single dose was able to confer protection from symptomatic COVID-19 and reduced severity of any breakthrough infections.16 Jun 2025 10:38 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lrprzislgs2zhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lqq2zcb3os2tJamie and Leo will be at #ExRdFest Saturday representing IMMPROVE 🧪🧬at the "would you get sick for science" stand 🧪🧬 talking about human challenge, vaccines and immunology! www.greatexhibitionroadfestival.co.uk https://www.imperial.ac.uk/institute-of-infection/about-us/pandemic-preparedness/human-challenge-studies/ immprove.ac.uk https://www.greatexhibitionroadfestival.co.uk/03 Jun 2025 19:54 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lqq2zcb3os2thttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lpccajpqk22wWe also have two new students, Priya and Nistha. Priya will be using wet and dry lab work to identify conserved T cell targets in HCoVs for vaccine design, and Nishtha will be studying how varied inhaled vaccines stimulate innate immunity and effects on T cell responses (3/3)16 May 2025 15:01 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lpccajpqk22whttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lpcc7qwplk2wWe're proud to host Dr Xiuyuan Lu from Osaka University as part of the IIT & IFReC exchange programme. She comes with great skills in analysing T cell vaccination responses. We're looking forward to her upcoming talk and of course future collaboration! (2/3) #UCL #IFReC #vaccine16 May 2025 15:00 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lpcc7qwplk2whttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lpcc4zw64k2wStanding room only our recent lab meeting! The group is growing fast, and lots of great science will surely come soon! (1/3)16 May 2025 14:59 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lpcc4zw64k2whttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhyh4tcms2d(2/2) My final thought for the day, is that from mechanistic insights or enhancing and developing medicines, it’s exciting to see quantitative research taking increasing space in immunology. Let’s keep the momentum going! Postdoc Peter, signing off. #qimmunoday10 Apr 2025 17:06 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhyh4tcms2dhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhyge5m4k2d(1/2) Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.10 Apr 2025 17:05 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhyge5m4k2dhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhqobh3p22x(3/3) Xiaowen Chen was the final presenter, and presented novel research into how we can infer resource competition from dynamic abundance data. A very interesting topic, which has some cool potential overlaps with T and B cell competition for antigens and/or cytokines. Now for posters!10 Apr 2025 14:46 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhqobh3p22xhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhqnffyo22x(2/3) Pebs Edwards presented some interesting data on the TCR repertoire in patients with lynch syndrome. A personal highlight for me was the 2 year persistence of neo-antigen clonotypes with apparent subsequent reactivation in at least one patient.10 Apr 2025 14:46 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhqnffyo22xhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhqlcgqok2x(1/2) Final set of talks now. Aubin Ramon started by describing his work to develop NanoMelt for nanobody thermostability assessment. The model uses ensemble learning on just 640 sequences, but accurately predicted Tm in a selection of nanobodies with at least 30% distance from the training set.10 Apr 2025 14:45 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhqlcgqok2xhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhmpsfsqs2x(2/2) Alastar Phelan then spoke about his mathematical modelling approach to enhance signal detection in dual pulse nucleoside labelling experiments for improving cell cycle analysis. Both speakers showcased their work really well, armed with only a pen and whiteboard! #qimmunoday10 Apr 2025 13:36 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhmpsfsqs2xhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhmolrvwc2x(1/2) A nice, unique feature of these days is the whiteboard talks. Michael Schneider went first and gave a nice explanation of how he is augmenting structure enhanced language models by improving MLM with intelligent token masking and space filling curves.10 Apr 2025 13:35 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhmolrvwc2xhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhgi3xdj22v(3/3) Alexis Farman discussed his mathematical models for CAR T cell migration conditions in a microfluidics device, focussing on chemoattractant availability. An interesting tidbit to finish on, where optimisation of receptor affinity was discussed, overlapping nicely with Pietro’s talk.10 Apr 2025 11:44 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhgi3xdj22vhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhgfh57x22v(2/3) Constantin Ahlmann-Eltze showcased impressive work on assembling an atlas of T cells in precancerous samples. They developed the R packages treelabel and Shinytreelabel, which showed GITR+ Tregs are enriched in several precancerous samples, suggesting avenues for future treatments10 Apr 2025 11:43 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhgfh57x22vhttps://bsky.app/profile/tcellvaccineucl.bsky.social/post/3lmhgdxp5t22v(1/3) Session 2 followed on with engaging talks. Pietro Sormanni discussed his group’s work on utilising ML to develop and enhance AIRR based therapeutics. Great to see this ML work backed up with experimental analysis. Work with industrial partners promises to produce real benefits for patients.10 Apr 2025 11:42 +0000at://did:plc:j4jffdrtzx2odd45vstucymp/app.bsky.feed.post/3lmhgdxp5t22v