Schraderlab.org - Enjoying all things related to RNA, RNPs, biomolecular condensates, and bacteriology. IU micro.https://bsky.app/profile/schraderlab.bsky.socialhttps://bsky.app/profile/schraderlab.bsky.social/post/3mqmlxqb25s2xNew preprint from my lab and Sean Crosson's lab at MSU. We show that BR-bodies in Brucella are linked to regulation of the type IV secretion system and stress tolerance. https://www.biorxiv.org/content/10.64898/2026.07.11.737834v114 Jul 2026 16:13 +0000at://did:plc:jmjkfmigg55tlchb4nao7pmt/app.bsky.feed.post/3mqmlxqb25s2xhttps://bsky.app/profile/schraderlab.bsky.social/post/3li2wbx5prs2uOur team found the N-terminal IDR of bacterial translation initiation factor 2 promotes condensation with RNA that is stimulated in the cold. We think these cold-stimulated IF2 condensates likely explain why the IDR's deletion in E. coli is unable to grow in the cold. https://www.biorxiv.org/content/10.1101/2025.02.02.631968v113 Feb 2025 14:42 +0000at://did:plc:jmjkfmigg55tlchb4nao7pmt/app.bsky.feed.post/3li2wbx5prs2uhttps://bsky.app/profile/schraderlab.bsky.social/post/3lbo5liuai226One year ago today my lab was destroyed in a fire. Nobody was hurt and our key freezer samples survived. My colleague Tamara Hendrickson has graciously hosted all my trainees in her lab since. In January, the Schrader Lab will be officially reopening at Indiana University.24 Nov 2024 04:16 +0000at://did:plc:jmjkfmigg55tlchb4nao7pmt/app.bsky.feed.post/3lbo5liuai226https://bsky.app/profile/schraderlab.bsky.social/post/3latibq2tl22kWe're very excited about the new preprint from @juliebiteenlab.bsky.social and our lab. We found that upon stress, BR-bodies material state becomes more solid/gel-like, changing their activity from mRNA decay to mRNA storage. Check it out here: https://www.biorxiv.org/content/10.1101/2024.11.12.623272v113 Nov 2024 13:46 +0000at://did:plc:jmjkfmigg55tlchb4nao7pmt/app.bsky.feed.post/3latibq2tl22k