A multidisciplinary community of researchers with the mission to better understand the roots of disease and narrow the gap between new biological insights and impact for patients. Broadinstitute.orghttps://bsky.app/profile/broadinstitute.orghttps://bsky.app/profile/broadinstitute.org/post/3mkimcetszk2oHave you ever wondered what animal superpowers can teach us about our own DNA? Join us in Cambridge, MA (or online) for a Broad Discovery Series talk on Wednesday, May 20 at 6 pm ET with Elinor Karlsson. Register: broadinstitute.swoogo.com/Karlsson27 Apr 2026 17:37 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mkimcetszk2ohttps://bsky.app/profile/broadinstitute.org/post/3mk424u4cpc26A new drug candidate designed to slow the progression of prion disease is entering a phase 1 clinical trial. The trial, led by Eric Minikel, codirector of Broad’s Prion Therapeutic Science program, will evaluate a divalent small interfering RNA (siRNA) drug candidate for safety and tolerability. https://broad.io/Prion-Phase122 Apr 2026 17:40 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mk424u4cpc26https://bsky.app/profile/broadinstitute.org/post/3mjk4wib3os2qThe Cancer Dependency Map Consortium is entering its third phase, accelerating the next generation of cancer therapies. (1/4) https://www.broadinstitute.org/news/cancer-dependency-map-consortium-launches-phase-3-accelerate-next-generation-therapeutics15 Apr 2026 14:42 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mjk4wib3os2qhttps://bsky.app/profile/broadinstitute.org/post/3mjhjmuwssk2mScientists corrected a genetic mutation that causes a rare, life-threatening condition, Zellweger spectrum disorder, in mice. The study points toward an optimal base editor enzyme with implications for other genetic diseases. broad.io/ZSD-News https://broad.io/ZSD-News14 Apr 2026 13:51 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mjhjmuwssk2mhttps://bsky.app/profile/broadinstitute.org/post/3mj3l2behfc2nLeukemia and possibly other cancers could be using sugary proteins on their cell surface to shield themselves from immune attack. New study points to potential cancer immunotherapy target. broad.io/CD43 @danafarbernews.bsky.social @mgbresearch.bsky.social https://broad.io/CD4309 Apr 2026 19:44 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mj3l2behfc2nhttps://bsky.app/profile/broadinstitute.org/post/3miehp6ijok2yNew study shows the promise of Cell Painting, an AI-powered, scalable cell-imaging method, to make drug toxicity testing faster, cheaper, and more information-rich in human cells—potentially reducing failed clinical trials and animal testing. http://broad.io/CP-DrugSafety31 Mar 2026 15:13 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3miehp6ijok2yhttps://bsky.app/profile/broadinstitute.org/post/3mhyf4xsvlk2wThe first ever large scale study of whole genomes from Anopheles darlingi -- a key malaria vector in the Americas -- reveals signs of emerging insecticide resistance. @jacobphd.bsky.social https://broad.io/Anopheles-darlingi26 Mar 2026 19:55 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mhyf4xsvlk2whttps://bsky.app/profile/broadinstitute.org/post/3mhvnhcggz22bChronic gut inflammation leaves behind “molecular scars” that may raise the risk for developing cancer, according to a new study showing that epigenetic memory of colitis, along with a cancer-promoting mutation, can accelerate tumor growth in mice. @jbuenrostro.bsky.social https://broad.io/colitis-news25 Mar 2026 17:46 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mhvnhcggz22bhttps://bsky.app/profile/broadinstitute.org/post/3mhvlmggzqk2xBy analyzing DNA data from over 900,000 people, a new study found that some of the most common viruses hiding in the body vary with age, sex, and the seasons — and that genes influence the long-term effects these viruses have on our health. https://broad.io/virome-news25 Mar 2026 17:13 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mhvlmggzqk2xhttps://bsky.app/profile/broadinstitute.org/post/3mgv62o7pz22pThe Stanley Family Foundation has renewed its commitment to psychiatric research at Broad Institute, bringing its total investment to more than $1 billion. This funding has advanced schizophrenia/bipolar disorder research, opening new paths to therapies. broad.io/SC-News12 Mar 2026 19:46 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mgv62o7pz22phttps://bsky.app/profile/broadinstitute.org/post/3mgs2j255gk22Join us March 18 at 6PM ET in Cambridge, MA (or online) for a Broad Discovery Series talk with Heidi Greulich and Matthew Meyerson, “The story behind a new therapy for lung cancer patients.” Register: broadinstitute.swoogo.com/Discovery2611 Mar 2026 14:04 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mgs2j255gk22https://bsky.app/profile/broadinstitute.org/post/3mgngzjpnmk2fAttention science/health reporters and editors: applications are open for Broad’s 2026 Media Boot Camp! Join us in Cambridge April 30–May 1 for a deep dive into emerging stories in biomedicine. Hotel & meals provided. Apply by Friday, March 20: broad.io/mediabootcamp http://broad.io/mediabootcamp09 Mar 2026 18:05 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mgngzjpnmk2fhttps://bsky.app/profile/broadinstitute.org/post/3mgasjxu3x227New research from @thexavierlab.bsky.social finds that the gut microbiome fine-tunes fat tissue in mice in response to diet, converting it from energy-storing fat to more energy-burning fat when dietary protein is low. http://broad.io/Fat-Cells-News04 Mar 2026 17:26 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mgasjxu3x227https://bsky.app/profile/broadinstitute.org/post/3mg6hccefw223Rescheduled to March 18 at 6 pm ET. Register: broadinstitute.swoogo.com/discovery26 [contains quote post or other embedded content]03 Mar 2026 19:00 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mg6hccefw223https://bsky.app/profile/broadinstitute.org/post/3mg4aazbcgc2hThe Catalyst program, led by Alabama nonprofit Southern Research, Broad Clinical Labs, and MyOme, Inc., provides free genetic testing to adult residents across Alabama to improve medical care and address chronic disease. https://broad.io/BCL-Catalyst02 Mar 2026 21:48 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mg4aazbcgc2hhttps://bsky.app/profile/broadinstitute.org/post/3mfrxprvzq22rThe same genetic variants that heighten the risk of autoimmune hypothyroidism — the most common autoimmune disorder — may also lower cancer risk, according to a new study led by scientists at Broad, @helsinki.fi, and @mgbresearch.bsky.social. broad.io/AIHT-news https://broad.io/AIHT-news26 Feb 2026 19:49 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mfrxprvzq22rhttps://bsky.app/profile/broadinstitute.org/post/3mfpejntc4k2nPinpointing the exact noncoding variants driving locus-disease associations is an enduring challenge. Using MPRA, a @jacksonlab.bsky.social, Broad & @yaleschoolofmed.bsky.social team tested >220,000 variants in 5 cell types, resolving >13,000 and revealing mechanisms behind several disease traits. https://www.broadinstitute.org/news/scientists-sharpen-genetic-maps-help-pinpoint-dna-changes-influence-human-health-traits-and25 Feb 2026 19:00 +0000at://did:plc:jptfie2af6bvnk5qqjs3jkph/app.bsky.feed.post/3mfpejntc4k2n