https://bsky.app/profile/lindnerlab.bsky.socialhttps://bsky.app/profile/lindnerlab.bsky.social/post/3melud4wsuc26Our new review article: clinical endpoints & translational challenges in #optogenetics for vision restoration. From patient expectations to #ClinicalTrial endpoints. First review to focus specifically on clinical perspective. https://doi.org/10.1007/s00347-026-02397-w #retina #GeneTherapy @unimarburg.bsky.social11 Feb 2026 16:07 +0000at://did:plc:jvsmp2ovtkjv6j66laeaospj/app.bsky.feed.post/3melud4wsuc26https://bsky.app/profile/lindnerlab.bsky.social/post/3mbvjgcspxk2dWe have created an (exhaustive - we think) directory of interventional clinical trials on optogenetic visual restoration: https://lindnerlab.de/index.php/publications/directory-of-optogenetic-trials. Hopefully a helpful resource for funders, researchers and regulators! #retina #GeneTherapy #optogenetics @unimarburg.bsky.social08 Jan 2026 08:03 +0000at://did:plc:jvsmp2ovtkjv6j66laeaospj/app.bsky.feed.post/3mbvjgcspxk2dhttps://bsky.app/profile/lindnerlab.bsky.social/post/3mbt4wgvst22mDelighted to see some more of our latest research online at BioRXiv: https://www.biorxiv.org/content/10.64898/2026.01.05.697593v1 We generated and characterized a mouse model for KCNV2 related retinal dystrophy. It nicely resembles key characteristics of the human disease phenotype. #retina #GeneTherapy @unimarburg.bsky.social07 Jan 2026 09:14 +0000at://did:plc:jvsmp2ovtkjv6j66laeaospj/app.bsky.feed.post/3mbt4wgvst22mhttps://bsky.app/profile/lindnerlab.bsky.social/post/3m6eqoo76gc2iLipid nanoparticles for retinal gene delivery - Read out latest preprint at biorxiv.org/content/10.1101/2025.11.21.689792v1 ! LNPs are able to transfect a variety of retinal cell types - including NEURONS! Previous ILM peeling improves efficacy! #retina #GeneTherapy #LNP @unimarburg.bsky.social24 Nov 2025 11:42 +0000at://did:plc:jvsmp2ovtkjv6j66laeaospj/app.bsky.feed.post/3m6eqoo76gc2ihttps://bsky.app/profile/lindnerlab.bsky.social/post/3lrd46dpbas2rERGtools2 — an #OpenSource R package for analyzing and managing visual electrophysiology data ( #ERG / #VEP ). Device-independent, reproducible, FAIR-compliant & ready for preclinical and clinical research. Paper: https://doi.org/10.1007/s10633-025-10017-2 Code: https://github.com/moritzlindner/ERGtools2 @unimarburg.bsky.social11 Jun 2025 09:35 +0000at://did:plc:jvsmp2ovtkjv6j66laeaospj/app.bsky.feed.post/3lrd46dpbas2rhttps://bsky.app/profile/lindnerlab.bsky.social/post/3lrd3scjzzk2rNew perspectives on #optogenetic #VisionRestoration In my letter in @moltherapy.bsky.social‬, I comment on recent clinical data on vMCO-010 and highlight the need for mechanistic insight & objective efficacy measures. Many open questions remain - exciting times ahead! @unimarburg.bsky.social #Retina11 Jun 2025 09:28 +0000at://did:plc:jvsmp2ovtkjv6j66laeaospj/app.bsky.feed.post/3lrd3scjzzk2rhttps://bsky.app/profile/lindnerlab.bsky.social/post/3lqwdqfyp3s2bOptogenetic Therapy in patients with residual visual function? In this study, we show that optogenetic responses complexly interact with native visual processing. https://doi.org/10.1172/jci.insight.190785 @unimarburg.bsky.social @ox.ac.uk @jci-insight.bsky.social ‬ #Optogenetics #Neuroscience #Retina #GeneTherapy06 Jun 2025 07:46 +0000at://did:plc:jvsmp2ovtkjv6j66laeaospj/app.bsky.feed.post/3lqwdqfyp3s2b