Staff Scientist at LIBD studying brain transcriptomics with #RStats 🧠 PhD Student in Neuroscience at University of Cambridge lahuuki.github.io https://bsky.app/profile/lahuuki.bsky.socialhttps://bsky.app/profile/lahuuki.bsky.social/post/3m7pkckfzrc2dExcited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression https://doi.org/10.1101/2025.11.20.689483 Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”11 Dec 2025 12:13 +0000at://did:plc:kfflbco44d6dfcs7gatyeve4/app.bsky.feed.post/3m7pkckfzrc2dhttps://bsky.app/profile/lahuuki.bsky.social/post/3m4ti7r4ksk2uProud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula https://doi.org/10.1176/appi.ajp.2024077604 Nov 2025 21:30 +0000at://did:plc:kfflbco44d6dfcs7gatyeve4/app.bsky.feed.post/3m4ti7r4ksk2uhttps://bsky.app/profile/lahuuki.bsky.social/post/3lqatqbqudc2eLearning more about APOE differences in the cell types of the brain 🧠 I presented "APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease" from @zhaonaa.bsky.social at our team journal club, check it out! https://doi.org/10.1016/j.neuron.2025.02.017 ▶️ youtu.be/L4J9jFS-Pic28 May 2025 18:33 +0000at://did:plc:kfflbco44d6dfcs7gatyeve4/app.bsky.feed.post/3lqatqbqudc2ehttps://bsky.app/profile/lahuuki.bsky.social/post/3lnnjsbgvvc2g25 Apr 2025 15:25 +0000at://did:plc:kfflbco44d6dfcs7gatyeve4/app.bsky.feed.post/3lnnjsbgvvc2ghttps://bsky.app/profile/lahuuki.bsky.social/post/3lmkahfebns2rHey #deconvolution fans! 👀 We’ve got an exciting new publication for you: a benchmark of 6 popular deconvolution methods on a multimodal human brain #DLPFC dataset 🧠🧬 Now out in Genome Biology: https://doi.org/10.1186/s13059-025-03552-3 @lieberinstitute.bsky.social @jhubiostat.bsky.social11 Apr 2025 14:34 +0000at://did:plc:kfflbco44d6dfcs7gatyeve4/app.bsky.feed.post/3lmkahfebns2rhttps://bsky.app/profile/lahuuki.bsky.social/post/3li4ybopykc23Check out my journal club presentation on the crumblr pre-print from Hoffman and Roussos, a new method to analyze differential composition in #singlecell data 🍪 Looks very useful for single cell RNA-seq data with case/control study design 🤔 📄 https://doi.org/10.1101/2025.01.29.635498 ▶️ https://www.youtube.com/watch?v=Hi5Eg1rBRnc14 Feb 2025 10:23 +0000at://did:plc:kfflbco44d6dfcs7gatyeve4/app.bsky.feed.post/3li4ybopykc23https://bsky.app/profile/lahuuki.bsky.social/post/3lcj6wn5hlc2sReading the instructions first next time 😅 completed "Ceres Search" - Day 4 - Advent of Code 2024 #AdventOfCode adventofcode.com/2024/day/4 https://adventofcode.com/2024/day/404 Dec 2024 22:22 +0000at://did:plc:kfflbco44d6dfcs7gatyeve4/app.bsky.feed.post/3lcj6wn5hlc2shttps://bsky.app/profile/lahuuki.bsky.social/post/3lcebidttl222I've completed "Red-Nosed Reports" - Day 2 - Advent of Code 2024 🔴 #AdventOfCode adventofcode.com/2024/day/2 https://adventofcode.com/2024/day/202 Dec 2024 23:25 +0000at://did:plc:kfflbco44d6dfcs7gatyeve4/app.bsky.feed.post/3lcebidttl222https://bsky.app/profile/lahuuki.bsky.social/post/3laqt5jrixk2sHi Bluesky! 👋 I'm Louise Huuki-Myers I work on transciptomic research in the brain 🧠🧬 @lieberinstitute.bsky.social and am Studying for my PhD in #neuroscience at the University of Cambridge. Excited to share more about neurosci research and #Rstats here 🦋12 Nov 2024 12:22 +0000at://did:plc:kfflbco44d6dfcs7gatyeve4/app.bsky.feed.post/3laqt5jrixk2s