Paediatric hepatologist | Liver inflammation | Ultra-runner | Dad https://jakepmann.com/https://bsky.app/profile/jakepmann.bsky.socialhttps://bsky.app/profile/jakepmann.bsky.social/post/3lp3diszccs2aI am excited to have arrived in Helsinki for @espghansociety.bsky.social Annual Meeting. I’ll be presenting some more of our biliary atresia data and recording a very exciting in-person version of the ESPGHAN podcast.13 May 2025 20:34 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lp3diszccs2ahttps://bsky.app/profile/jakepmann.bsky.social/post/3lozwyly3h225Here's a preprint of our work where we found that most genes which cause monogenic, severe liver disease also affect the onset and/or severity of liver-related traits in adults. [Not yet peer reviewed.] https://doi.org/10.1101/2025.05.09.2532640713 May 2025 07:18 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lozwyly3h225https://bsky.app/profile/jakepmann.bsky.social/post/3lol6h63xsc2dI’m at @easlnews.bsky.social Congress in Amsterdam this week and sharing some of our biliary atresia data tomorrow07 May 2025 10:21 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lol6h63xsc2dhttps://bsky.app/profile/jakepmann.bsky.social/post/3lnmx535mfc22https://jakepmann.com/working-on-and-in-the-lab/?trk=feed-detail_main-feed-card_feed-article-content25 Apr 2025 09:51 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lnmx535mfc22https://bsky.app/profile/jakepmann.bsky.social/post/3lmxdqsgajc2qI remember seeing this work presented last year and it’s stunning. [contains quote post or other embedded content]16 Apr 2025 19:38 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lmxdqsgajc2qhttps://bsky.app/profile/jakepmann.bsky.social/post/3lmi2rzunw22h2nd run of Visium HD complete 🫡10 Apr 2025 17:48 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lmi2rzunw22hhttps://bsky.app/profile/jakepmann.bsky.social/post/3lmeprnx7zk2nThe downside of being totally focused on functional experiments for my fellowship application is that I have become a '40 unread emails' person09 Apr 2025 09:53 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lmeprnx7zk2nhttps://bsky.app/profile/jakepmann.bsky.social/post/3llww65mqus2wAnd here I am thinking that my multicolour immunofluorescence is pretty [contains quote post or other embedded content]03 Apr 2025 22:10 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3llww65mqus2whttps://bsky.app/profile/jakepmann.bsky.social/post/3llrjapclyk2yThe real question is ‘will I ever find a paper that Alex (Knisley) thinks is free of major flaws?’ [contains quote post or other embedded content]01 Apr 2025 18:35 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3llrjapclyk2yhttps://bsky.app/profile/jakepmann.bsky.social/post/3lldq67fvw22tI’m back up in Edinburgh this week learning new spatial techniques and using some very rare paediatric samples. All round quite exciting.27 Mar 2025 07:02 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lldq67fvw22thttps://bsky.app/profile/jakepmann.bsky.social/post/3ljkxx3jwk223I _think_ we needed to dilute our samples a bit more04 Mar 2025 17:19 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3ljkxx3jwk223https://bsky.app/profile/jakepmann.bsky.social/post/3ljdfemucfk2aI know I'm biased, but I'd say this is a particularly good one. Keep sending me your feedback and requests! [contains quote post or other embedded content]01 Mar 2025 16:58 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3ljdfemucfk2ahttps://bsky.app/profile/jakepmann.bsky.social/post/3ljdehniblk2v01 Mar 2025 16:42 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3ljdehniblk2vhttps://bsky.app/profile/jakepmann.bsky.social/post/3lj5ifs3q4k2iThe CRUK Clinical PhD Programme at @unibirmingham.bsky.social is open for applications. This is an amazing opportunity. If you're interested in applying, then I have project around the immunology of hepatocellular carcinoma (and also some HCC GWAS hits to follow-up) so get in touch! https://www.birmingham.ac.uk/schools/mds-graduate-school/scholarships/cruk27 Feb 2025 08:36 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lj5ifs3q4k2ihttps://bsky.app/profile/jakepmann.bsky.social/post/3lizv7t3ca22rI’m enjoying Tim Urban’s book and I’m doing my best to follow his advice “What if I’m wrong about some of what I think?”25 Feb 2025 22:15 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lizv7t3ca22rhttps://bsky.app/profile/jakepmann.bsky.social/post/3liydcvniyk22I’m coming to conclusion of a GWAS project and only now truly starting to understand what pruning and fine-mapping means. And LocusZoom is wonderful.25 Feb 2025 07:22 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3liydcvniyk22https://bsky.app/profile/jakepmann.bsky.social/post/3liujpujvb22gI like to differentiate between the ‘messing around’ experiments and the ‘proper’ ones. Much of the time in the lab I’m trying new stuff, testing meddling around with the protocol and seeing if there’s any hint it works. It’s low risk and really fun.23 Feb 2025 19:06 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3liujpujvb22ghttps://bsky.app/profile/jakepmann.bsky.social/post/3liu6cxbojc2g🎁 [contains quote post or other embedded content]23 Feb 2025 15:42 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3liu6cxbojc2ghttps://bsky.app/profile/jakepmann.bsky.social/post/3lipje33ff22qType 2 fun in research: Yesterday I thought I was “done” with first draft of a paper, only to do a double-check and find a substantial error that will take at least two days’ work. Frustrating but I am glad to have caught it.21 Feb 2025 19:16 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lipje33ff22qhttps://bsky.app/profile/jakepmann.bsky.social/post/3lin3d2cecs2eThe year I applied to paediatric hepatology there was n=1 job in the UK, but with the increasing competition ratios, I sometimes wonder whether I am already too out of touch to really understand what it is like to be a trainee clinician in the UK. Good luck to all receiving GRID results around now20 Feb 2025 20:00 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lin3d2cecs2ehttps://bsky.app/profile/jakepmann.bsky.social/post/3limmthykac2eSpatial and single-cell imaging technologies are great but don’t underestimate: 1) the time required for optimisation 2) the depth vs coverage balance 3) the complexity of analysis Plus the fear of ruining a slide after you’ve already paid for it20 Feb 2025 15:40 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3limmthykac2ehttps://bsky.app/profile/jakepmann.bsky.social/post/3likutfgt5c2eThis must have been a difficult study to do and the results are important. I’ll be interested to see what happens in the next 1-2 years; whether a brief period of hypocaloric diet at a critical phase of insulin resistance affects long-term risk of diabetes [contains quote post or other embedded content]19 Feb 2025 22:58 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3likutfgt5c2ehttps://bsky.app/profile/jakepmann.bsky.social/post/3lijp7eqblk2eToday I am considering the merits of various methods/combinations of single-cell imaging and sequencing technologies for a large paediatric study I’ll be running soon But more importantly, Edinburgh has great sunrises19 Feb 2025 11:45 +0000at://did:plc:kpyyfeoadgmagen4epvmwzkr/app.bsky.feed.post/3lijp7eqblk2e