Weyerhaeuser Endowed Professor of Chemical Engineering & Bioengineering, University of Washington | User-Programmable Biomaterials | Photochemistry | Optogenetics | Protein Engineering http://www.coledeforest.comhttps://bsky.app/profile/coledeforest.bsky.socialhttps://bsky.app/profile/coledeforest.bsky.social/post/3m6kxea4oqk2nThe publishing streak continues! Excited to share our new article in Nature Reviews Materials (@natrevmats.nature.com) entitled "Engineering Complexity into Protein-based Biomaterials for Biomedical Applications"! Check it out here: 📜: https://doi.org/10.1038/s41578-025-00861-8 🔓: rdcu.be/eRFDh26 Nov 2025 22:58 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3m6kxea4oqk2nhttps://bsky.app/profile/coledeforest.bsky.social/post/3m667fdhz3c24Check out our new paper entitled "Boolean Logic-based Controlled Release of Bioactive Proteins with Diversified Inputs", live in @angewandtechemie.bsky.social ! Growth factors, enzymes, nanobodies, and cytokines can now be "logically" delivered! 📜: https://onlinelibrary.wiley.com/doi/10.1002/anie.20251992521 Nov 2025 21:17 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3m667fdhz3c24https://bsky.app/profile/coledeforest.bsky.social/post/3m3nvhrskq22aOur latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@cp-cellbiomat.bsky.social, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"! 🔓 : https://www.cell.com/cell-biomaterials/fulltext/S3050-5623(25)00230-220 Oct 2025 22:46 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3m3nvhrskq22ahttps://bsky.app/profile/coledeforest.bsky.social/post/3m33mpypzac2zOur new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology (@natchembio.nature.com)! Check it out! 📜: https://www.nature.com/articles/s41589-025-02037-5 @uwnews.uw.edu feature write-up: https://www.washington.edu/news/2025/10/09/programmable-proteins-targeted-drug-delivery-synthetic-biology/13 Oct 2025 16:22 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3m33mpypzac2zhttps://bsky.app/profile/coledeforest.bsky.social/post/3lynzo5fjbk2eNew in @ScienceMagazine, we report that dilated cardiomyopathy can be alleviated by preventing hypocontractility-induced fibroblast expansion! The story is a fun combination of advanced in vivo and biomaterial-based in vitro models. Check it out! 📜 : https://doi.org/10.1126/science.adv915712 Sep 2025 19:46 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3lynzo5fjbk2ehttps://bsky.app/profile/coledeforest.bsky.social/post/3lxxe3ka6ik2gOur new manuscript entitled "PhoCoil: A Photodegradable and Injectable Single-component Recombinant Protein Hydrogel for Minimally Invasive Delivery and Degradation" is now live at @ScienceAdvances! Check it out here (🔓): https://www.science.org/doi/10.1126/sciadv.adx347203 Sep 2025 19:21 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3lxxe3ka6ik2ghttps://bsky.app/profile/coledeforest.bsky.social/post/3lwcmmyzhlc2qCheck out our new paper entitled "Genetically Encoded Interpenetrating Polymer Networks as Injectable Biomaterials for Controlled Therapeutic Protein Delivery", appearing in ACS Biomat Science & Eng! https://pubs.acs.org/doi/10.1021/acsbiomaterials.5c0081313 Aug 2025 20:03 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3lwcmmyzhlc2qhttps://bsky.app/profile/coledeforest.bsky.social/post/3lp3azinuxs25For the 2nd year in a row, one of our lab members has been selected for the prestigious Goldwater Scholarship. Huge congrats to Shivani Kottantharayil for her 2025 selection (and to Annabella Li for receiving the award last year)! UW press release is here: https://www.washington.edu/uaa/2025/04/21/four-uw-undergraduates-named-2025-goldwater-scholars/13 May 2025 19:50 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3lp3azinuxs25https://bsky.app/profile/coledeforest.bsky.social/post/3llwaadyvec2lIn our latest manuscript, we demonstrate that grayscale control over local #biomaterial biochemistry and mechanics can be rapidly achieved across large constructs using an inexpensive (~$300) and commercially available LCD-based printer. Find it published in JBMR-A! https://doi.org/10.1002/jbm.a.3789703 Apr 2025 15:37 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3llwaadyvec2lhttps://bsky.app/profile/coledeforest.bsky.social/post/3ld54yal6x22iHappy Holidays from the DeForest Lab! What fun to celebrate the group’s 2024 achievements, especially in the baking sector. Our annual dessert bake-off competition was a tasty success!12 Dec 2024 20:41 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3ld54yal6x22ihttps://bsky.app/profile/coledeforest.bsky.social/post/3ld4t537zic2iThe Anseth lab continues to pioneer many of the best and most versatile photoresponsive biomaterials known to our community. Congrats to @monicaohnsorg.bsky.social and Ella Hushka for summarizing the group's last 15 years of exciting efforts in their new paper! [contains quote post or other embedded content]12 Dec 2024 17:45 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3ld4t537zic2ihttps://bsky.app/profile/coledeforest.bsky.social/post/3lcijqb3oqs24Fun story from @matthewfainor.bsky.social on how next-gen recombinant proteins are being expressed in fruit flies, and what implications that could have for our lab-grown hydrogel biomaterials! [contains quote post or other embedded content]04 Dec 2024 16:03 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3lcijqb3oqs24https://bsky.app/profile/coledeforest.bsky.social/post/3lce2bdt4vs2xProfessors often tell graduate students that “Your PhD is a #marathon, not a sprint”. Having now run the 2024 Seattle Marathon (many years after finishing a PhD), I now actually feel qualified to make such a statement. @uwmedicine.bsky.social02 Dec 2024 21:16 +0000at://did:plc:krasqabtg5qupvtbh2araxmr/app.bsky.feed.post/3lce2bdt4vs2x