#OpenAccess @embopress.org journal publishing pioneering research in systems & synthetic biology, systems medicinehttps://bsky.app/profile/molsystbiol.orghttps://bsky.app/profile/molsystbiol.org/post/3mvaxjcen5s2d9/2026 Issue ➡️ https://link.springer.com/journal/44320/volumes-and-issues/22-9 #XLMS analysis, multi-omics integration, skeletal muscle insulin resistance, sweeteners affect gut microbes, nonenzymatic protein functions Cover: E. coli engineered to swarm in various patterns11 Sep 2026 16:13 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mvaxjcen5s2dhttps://bsky.app/profile/molsystbiol.org/post/3mrfbvo4dt22uEvolutionary modeling of chemotherapy-resistant cells show combination chemo+disulfiram treatment reduces resistance more than sequential therapy ➡️ https://link.springer.com/article/10.1038/s44320-026-00191-z24 Jul 2026 11:49 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mrfbvo4dt22uhttps://bsky.app/profile/molsystbiol.org/post/3mqmdunlawk2gauthors developed computational framework VEFill to impute missing deep mutational scanning (DMS) scores for variant effect prediction ➡️ https://link.springer.com/article/10.1038/s44320-026-00203-y14 Jul 2026 13:48 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mqmdunlawk2ghttps://bsky.app/profile/molsystbiol.org/post/3mpqvbrzje22f7/2026 Issue ➡️ https://link.springer.com/journal/44320/volumes-and-issues/22-7 spatially-informed RNA velocity, cell identity and metabolomics, breast cancer combination therapy, B cell differentiation #GRNs, single-cell omics ensemble learning Cover: #morphodynamic features predict epithelial fate @kuba-sedzinski.bsky.social03 Jul 2026 15:45 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mpqvbrzje22fhttps://bsky.app/profile/molsystbiol.org/post/3mo46ahcid22b6/2026 Issue ➡️ https://link.springer.com/journal/44320/volumes-and-issues/22-6 plasmid-free protein engineering, #DMS analysis, microbial surface functionalization, glioma cell interactions, viral mimic evolution Cover: generative AI for antibiotic synthesis design by Jonathan Stokes and @jameszou.bsky.social labs12 Jun 2026 16:34 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mo46ahcid22bhttps://bsky.app/profile/molsystbiol.org/post/3mnfaw2yed22ja modular chemical surface‑functionalization method was developed by attaching diverse azide‑tagged groups to microbes ➡️ https://link.springer.com/article/10.1038/s44320-026-00202-z03 Jun 2026 13:51 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mnfaw2yed22jhttps://bsky.app/profile/molsystbiol.org/post/3ml4b4o7tvk2m5/2026 Issue ➡️ https://link.springer.com/journal/44320/volumes-and-issues/22-5 melanoma drug response, #Parkinson's and cancer signatures, human nucleosome patterns, epigenetic changes during aging, single-cell state transitions Cover: solid and liquid biopsies capture intratumoral heterogeneity @delphine-merino.bsky.social lab05 May 2026 13:10 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3ml4b4o7tvk2mhttps://bsky.app/profile/molsystbiol.org/post/3mka3ngwg3c2vauthors developed a modular chemical surface‑functionalization method by attaching diverse azide‑tagged groups to microbes ➡️ https://link.springer.com/article/10.1038/s44320-026-00202-z24 Apr 2026 08:17 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mka3ngwg3c2vhttps://bsky.app/profile/molsystbiol.org/post/3mk354r2mms2cauthors developed a computational tool, State Transition Inference using Cross-cell Correlations (STICCC), to predict both net and reversible cell state transitions using a #GRN and single-cell gene expression data ➡️ https://link.springer.com/article/10.1038/s44320-026-00196-822 Apr 2026 09:01 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mk354r2mms2chttps://bsky.app/profile/molsystbiol.org/post/3mjyxiyrtbc27@matemanc.bsky.social lab shows that amino acid substitutions in cancer can be grouped into five recurrent signatures, and the individual properties of these signatures can shape tumor microenvironment ➡️ https://link.springer.com/article/10.1038/s44320-026-00193-x21 Apr 2026 12:15 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mjyxiyrtbc27https://bsky.app/profile/molsystbiol.org/post/3mjwgfbkzrk2lchemical mapping generated human single-base-pair–resolution nucleosome positioning maps during interphase and metaphase, revealing widespread nucleosome repositioning at gene regulatory regions across the cell cycle ➡️ https://link.springer.com/article/10.1038/s44320-026-00192-y20 Apr 2026 12:03 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mjwgfbkzrk2lhttps://bsky.app/profile/molsystbiol.org/post/3mjojufwojc2xgene dosage is variably buffered by protein abundance in cancer, with buffering capacity linked to altered oncogenic potential and altered drug sensitivity ➡️ https://link.springer.com/article/10.1038/s44320-026-00187-917 Apr 2026 08:44 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mjojufwojc2xhttps://bsky.app/profile/molsystbiol.org/post/3mjojn7hqhs2xengineered chromosome fusions reveal constraints on chromosome length due to spindle axis length ➡️ https://link.springer.com/article/10.1038/s44320-026-00188-817 Apr 2026 08:40 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mjojn7hqhs2xhttps://bsky.app/profile/molsystbiol.org/post/3mjohzkpois2x4/2026 Issue ➡️ https://link.springer.com/journal/44320/volumes-and-issues/22-4 chromosome length limits, infection affects human tRNAs, fitness costs to antifungal resistance, protein buffering of aneuploidy, Dictyostelid genome editing Cover: Pooled-AlphaFold3 reveals folding complexes more accurate than a pairwise approach17 Apr 2026 08:11 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mjohzkpois2xhttps://bsky.app/profile/molsystbiol.org/post/3mhswoosua22ufitness costs are associated with acquired antifungal resistance in N. glabratus, and these trade-offs can be targeted by drugs as shown by @gabaldonlab.bsky.social ➡️ https://link.springer.com/article/10.1038/s44320-025-00185-324 Mar 2026 15:54 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mhswoosua22uhttps://bsky.app/profile/molsystbiol.org/post/3mhsvowo43s2uprotein conformational changes are detected on a proteome-wide scale in live cells by LiP-MS method from @picottilab.bsky.social, which they use to show changes in biomolecular condensates upon arsenite stress ➡️ https://link.springer.com/article/10.1038/s44320-025-00182-624 Mar 2026 15:36 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mhsvowo43s2uhttps://bsky.app/profile/molsystbiol.org/post/3mgg44tyyzc2t3/2026 Issue ➡️ https://link.springer.com/journal/44320/volumes-and-issues/22-3 genomic language models, proteomics practices, host-microbiome, bacterial tumor colonization, pooled single-cell screening, scRNA-seq clustering Cover (www.scistories.com): @picottilab.bsky.social probed in-cell protein structural changes06 Mar 2026 20:01 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mgg44tyyzc2thttps://bsky.app/profile/molsystbiol.org/post/3mdxnwqxyec2tiPS2-seq is a clone-aware platform for #singlecell loss-of-function screening in #hiPSCs and derivatives including #organoids, here revealing SMAD2 role in cardiac progenitor specification from @berterolab.bsky.social @mendjanlab.bsky.social #functionalgenomics ➡️ https://link.springer.com/article/10.1038/s44320-025-00172-803 Feb 2026 15:20 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mdxnwqxyec2thttps://bsky.app/profile/molsystbiol.org/post/3mdxm2wd5t22t2/2026 Issue ➡️ https://link.springer.com/journal/44320/volumes-and-issues/22-2 expansion microscopy, spatial omics and gene networks, cell population control by cell cycle, #IBD heterogeneity, aging monkey lipid signatures Cover: single-cell loss-of-function screening in human pluripotent stem cells from @berterolab.bsky.social03 Feb 2026 14:46 +0000at://did:plc:kvp5b2itofx22ltuiryfmm4w/app.bsky.feed.post/3mdxm2wd5t22t