JAMA Psychiatry is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications. 🌐 JAMAPsychiatry.comhttps://bsky.app/profile/jamapsychiatry.comhttps://bsky.app/profile/jamapsychiatry.com/post/3mv3uvarx7k2yIn a Danish cohort, parental similarity for #PsychiatricDisorders was substantial and was associated with higher prevalence and higher family-based heritability than expected under random mating. ja.ma/3TpVqjj09 Sep 2026 15:43 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mv3uvarx7k2yhttps://bsky.app/profile/jamapsychiatry.com/post/3muwe4ka3lk27💬 Viewpoint: In #Psychiatry, large language models should be used as clinical instruments, with clinician accountability and source-grounded verification before output influences care. ja.ma/4xeSxQq07 Sep 2026 11:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3muwe4ka3lk27https://bsky.app/profile/jamapsychiatry.com/post/3muu7px3ymb2h💡 Special Communication: In psychiatry, #PolygenicScores, rare variant testing, and #Pharmacogenomics may have value when used selectively to inform diagnosis, prognosis, monitoring, and medication safety rather than population-wide screening. ja.ma/3UD8l1I06 Sep 2026 14:36 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3muu7px3ymb2hhttps://bsky.app/profile/jamapsychiatry.com/post/3muu6ttvmca2pAmong adults with serious mental illness, #GLP1 receptor agonists vs #SGLT2 inhibitors were associated with lower mortality and fewer major cardiovascular events, with greater absolute benefit in serious mental illness. ja.ma/4r3cmZy06 Sep 2026 14:20 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3muu6ttvmca2phttps://bsky.app/profile/jamapsychiatry.com/post/3muu6nnb54q2z💬 Viewpoint: Family-based care for #Psychosis may need to address the digital home, where #SocialMedia and #ArtificialIntelligence shape symptom interpretation, conflict, treatment beliefs, and relapse warning signs. ja.ma/4A0j7zd06 Sep 2026 14:16 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3muu6nnb54q2zhttps://bsky.app/profile/jamapsychiatry.com/post/3mucdqhkd4w24GLP-1 receptor agonist use and misuse were common among people with #EatingDisorders, with many reporting adverse events, underscoring the need for pharmacovigilance as availability increases. ja.ma/3SaIDkj https://ja.ma/3SaIDkj30 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mucdqhkd4w24https://bsky.app/profile/jamapsychiatry.com/post/3mu5csnojvx24The FDA approved gepirone extended release for #Depression based on 2 positive trials despite 11 negative or inconclusive trials, highlighting the agency's use of regulatory flexibility and trial-level statistical significance. ja.ma/4g6sYM8 https://ja.ma/4g6sYM828 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mu5csnojvx24https://bsky.app/profile/jamapsychiatry.com/post/3mu2sdqgbhk26Systemic interleukin-6 inhibition demonstrated treatment-sensitive outcomes and clinically meaningful effect sizes in patients with difficult-to-treat #Depression and low-grade #Inflammation. ja.ma/4qkzTVg https://ja.ma/4qkzTVg27 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mu2sdqgbhk26https://bsky.app/profile/jamapsychiatry.com/post/3mtybusn4f723Exposure to #ChildhoodTrauma was linked to #BipolarDisorder in part via reduced volume of the hippocampus and thinner cortex in the medial orbitofrontal and superior frontal gyrus. ja.ma/4zpGgKW https://ja.ma/4zpGgKW26 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mtybusn4f723https://bsky.app/profile/jamapsychiatry.com/post/3mtvrfulns727In individuals at clinical high risk for #psychosis, reduced temporal stability of EEG microstates was associated with earlier conversion and increased positive symptom severity. ja.ma/4gitPrI https://ja.ma/4gitPrI25 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mtvrfulns727https://bsky.app/profile/jamapsychiatry.com/post/3mttawx3dox2iIn a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism. ja.ma/4gBALkZ https://ja.ma/4gBALkZ24 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mttawx3dox2ihttps://bsky.app/profile/jamapsychiatry.com/post/3mtqqi2oryn2tFamily genetic risk scores across 18 psychiatric disorders indicated six correlated factors: psychotic, externalizing, anxiety, neurodevelopmental, mood, and eating disorders. ja.ma/4zpGgdU https://ja.ma/4zpGgdU23 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mtqqi2oryn2thttps://bsky.app/profile/jamapsychiatry.com/post/3mto7z53ae62nIndividualized, connectivity-based targeting of accelerated transcranial magnetic stimulation produced significantly greater antidepressant effects than scalp-based targeting in adults with treatment-resistant #Depression. ja.ma/4hzMkdA https://ja.ma/4hzMkdA22 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mto7z53ae62nhttps://bsky.app/profile/jamapsychiatry.com/post/3mtlpk7hpz424In #StimulantUseDisorder trials, no medication significantly outperformed placebo for abstinence, but cabergoline supported greater reduced cocaine use when nonabstinence outcomes were included. ja.ma/4zpGdie https://ja.ma/4zpGdie21 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mtlpk7hpz424https://bsky.app/profile/jamapsychiatry.com/post/3mtj73bwdrj2cDisease development trajectories in #MentalDisorders vary by diagnosis at first contact, sex, and age, with younger patients exhibiting more diagnostic shifts and psychiatric contacts, highlighting the need for targeted preventive care. ja.ma/4zpGd1I https://ja.ma/4zpGd1I20 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mtj73bwdrj2chttps://bsky.app/profile/jamapsychiatry.com/post/3mth4ciepiw27💬 Viewpoint: #Suicide risk models are advancing, but health systems often lack the infrastructure needed to select, implement, recalibrate, and sustain them in routine care. ja.ma/4zqL9Dz19 Aug 2026 16:05 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mth4ciepiw27https://bsky.app/profile/jamapsychiatry.com/post/3mth2dudtcg2dAmong young adults at varying #ManiaRisk, greater left ventrolateral prefrontal cortex activation during reward expectancy was associated with lower delay discounting, consistent with greater sensitivity to reward value. ja.ma/45wROP519 Aug 2026 15:30 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mth2dudtcg2dhttps://bsky.app/profile/jamapsychiatry.com/post/3mtgomepdnc2d💬 Editorial: Connectivity-based targeting for transcranial magnetic stimulation demonstrated greater antidepressant effects and precision than scalp-based approaches in adults with treatment-resistant #Depression. ja.ma/4g1LvZU https://ja.ma/4g1LvZU19 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mtgomepdnc2dhttps://bsky.app/profile/jamapsychiatry.com/post/3mte65gfp7c2i💬 Editorial: Reduced temporal stability of #EEG microstates shows promise as a scalable biomarker for predicting clinical outcomes in individuals at high risk for psychosis. ja.ma/3SfpXzG https://ja.ma/3SfpXzG18 Aug 2026 12:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mte65gfp7c2ihttps://bsky.app/profile/jamapsychiatry.com/post/3mte2s5at6y23Systemic interleukin-6 inhibition demonstrated treatment-sensitive outcomes and clinically meaningful effect sizes in patients with difficult-to-treat #Depression and low-grade #Inflammation. ja.ma/3RD95Ta https://ja.ma/3RD95Ta18 Aug 2026 11:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mte2s5at6y23https://bsky.app/profile/jamapsychiatry.com/post/3mtbkd7uuhj2tExposure to #ChildhoodTrauma was linked to #BipolarDisorder in part via reduced volume of the hippocampus and thinner cortex in the medial orbitofrontal and superior frontal gyrus. ja.ma/4h2v8NF https://ja.ma/4h2v8NF17 Aug 2026 11:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mtbkd7uuhj2thttps://bsky.app/profile/jamapsychiatry.com/post/3mt6zucn2h524In individuals at clinical high risk for #psychosis, reduced temporal stability of EEG microstates was associated with earlier conversion and increased positive symptom severity. ja.ma/3RGKAo9 https://ja.ma/3RGKAo916 Aug 2026 11:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mt6zucn2h524https://bsky.app/profile/jamapsychiatry.com/post/3mt4jfeyy6v23💬 Editorial: Connectivity-based targeting for transcranial magnetic stimulation demonstrated greater antidepressant effects and precision than scalp-based approaches in adults with treatment-resistant #Depression. ja.ma/4hAsSNY15 Aug 2026 11:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mt4jfeyy6v23https://bsky.app/profile/jamapsychiatry.com/post/3mszywhwckk24In a cohort study, #PolygenicScores identified more patients at risk for #ADHD, #Depression, and #Schizophrenia than recurrent copy number variants, while both methods were complementary for risk assessment in #Autism. ja.ma/4h3t0Fg https://ja.ma/4h3t0Fg14 Aug 2026 11:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3mszywhwckk24https://bsky.app/profile/jamapsychiatry.com/post/3msxsjgmot423Early clinical studies suggest that low-intensity #FocusedUltrasound can modify symptom-relevant circuitry and may improve psychiatric symptoms, but translation will depend on safety standards, target validation, and standardized reporting. ja.ma/4gcnEFK https://ja.ma/4gcnEFK13 Aug 2026 14:00 +0000at://did:plc:l5ntoppfqwcqcotr64wciofo/app.bsky.feed.post/3msxsjgmot423