@rheumnow.bsky.social - Dr. John Cush

01 Oct 2026 23:00 +0000

Observational study of 228 #PsA pts Rx biologics, either early (<2yrs; mean 6 mos) vs later (mean 3.6 yrs). Groups were balanced in all parameters; after 6 mos no diff in DAPSA50 or PASI75 response. Biologics work regardless of when started. buff.ly/EHG2yXz https://buff.ly/EHG2yXz

01 Oct 2026 19:38 +0000

ARthritis & CAncer (ARCA) is Spanish retro study of 728 #RA pts w/ Hx of CA & Rx w/ biologics. W/ F/U of 11 022 yrs, new/recurrent CA was not incr (7.3/1000PYs) & = Pts Rx w/ csDMARDs (HRs 0.94; 0.73,1.21) & not incr w/ TNFi (0.94), IL-6i (1.03), CD20i (0.81), JAKi (0.6), ABA (0.74) buff.ly/GSD3ehs

01 Oct 2026 19:01 +0000

Obesity & Biologic Treatment Response Prepared for "The Obesity Imperative" campaign. buff.ly/krgxWwU

01 Oct 2026 18:00 +0000

Treatment for Obesity and Inflammation, but at what Cost? buff.ly/ZoAUyCz

30 Sep 2026 23:00 +0000

Worldwide the Sjögren’s disease market size across was valued at approximately $1 billion USD in 2025 and is projected to reach nearly $10 billion USD by 2036 (with annual growth of 26.2% during the forecast period from 2026 to 2036). buff.ly/wAKRrxV https://buff.ly/cs7BOuI

30 Sep 2026 20:58 +0000

Amgen announced topline results from the Phase 3 OASIZ 301 study showing the efficacy of dazodalibep in Sjögren's dz, w/ signif ESSDAI improvements at wek 48. DAZO is a CD40L antagonist fusion protein buff.ly/y9rQaOA

30 Sep 2026 15:00 +0000

Mediterranean Diet Lowers Incident RA Risk The American Journal of Clinical Nutrition has published the results of the SUN Project study, showing that long-term adherence to a MedDiet was associated with a substantially lower risk of incident RA, but not psoriasis. buff.ly/iQ0VJIb

30 Sep 2026 14:00 +0000

GCA international survey of 155 specialists (rheums 51%; ophthal 33%). w/ GCA dx, ASA started in only 15%; w/ 69.5% uncertain. w/ visual loss, 93% Rheums, 85% Ophthal Rx w/ IVGC, followed by oral. Uncertainty for IV versus po GC seen in 68.5% buff.ly/oY9uAs5 https://buff.ly/PGeWDWI

29 Sep 2026 21:00 +0000

Do biologic Rx lower risk of PsA? Metanalysis (15 studies, 124,138 psoriasis pts, 778K PYrs F/U), showed Biologic use assoc w/ lower risk of PsA (HR 0.54); best for IL-17i (0.65) & IL-12/23 or IL-23i (0.46) vs TNFi. IL-23i superior to IL-17i (HR 0.67) buff.ly/N4froBW https://buff.ly/MrxU7sj

29 Sep 2026 19:00 +0000

Obesity as a Risk Factor for Rheumatic Diseases buff.ly/P3Xg2eb

29 Sep 2026 18:00 +0000

BMJ reports TriNetX EHR study showing GLP-1 RA use in knee OA pts was assoc w/ significantly lower cumulative TKA incidence (p<0.001). 1 year any GLP-1 RA (HR 0.90) or 3 yrs exposure (HR 0.72) signif lowered TKA 8 yrs later buff.ly/yDUiIxs

29 Sep 2026 16:00 +0000

The Need for Weight Loss and Weight Gain in the ILD Clinic buff.ly/DgLwvMj

29 Sep 2026 15:00 +0000

Metanalysis of Metabolic syndrome (MetS) in #SLE (65 articles, 11K pts). MetS prevalence 27% (higher in males (36 vs 27%). HCQ assoc w/ signif less MetS (OR 0.66), but more w/ CTX (1.39), AZA (1.25), MMF (1.13), but not steroids or MTX. MetS pts were older, obese, w/ high Chol & LDL buff.ly/VQNvSI9

29 Sep 2026 14:01 +0000

Retrospective study from India on 157 juvenile dermatomyositis (JDM) pts - 44 (28%) had calcinosis. They had a long Dx delay (12 mos), were NXP2+ in 41%, & high risk for Lipodystrophy (39% vs 5%). 39% improved while 61% had static/progressive Dz buff.ly/sYUD9kU https://buff.ly/sYUD9kU

28 Sep 2026 21:00 +0000

52 VEXAS pts Rx w/ IL‐1i, IL‐6i, or JAKi therapy judged as compl Resp (CR), partial (PR), Failure (TF). @ 6mos: 3/19 IL‐6i had CR, 4/19 PR, 7/19 TF. JAKi had 2/17 CR, 3/17 PR, 6/17 TF. No CR w/ IL‐1i or TNFαi, only 1/5 IL‐1i patients experienced PR. buff.ly/tsRr6gg

28 Sep 2026 19:02 +0000

Systematic review of 21 papers (23K RA pts) finds 12% w/ difficult-to-treat RA. Risk factors -- smoking (OR 1·16), obesity (1·38), FM (2·20) & depression (1·74). No assoc w/ current smoking or anxiety. buff.ly/pDHkt5O https://buff.ly/pDHkt5O

28 Sep 2026 18:01 +0000

Upadacitinib is now approved in European Union to treat active polyarticular juvenile idiopathic arthritis (pJIA) ages > 2yrs for those not responding to 1+ DMARDs. In the USA, UPA is approved for pJIA & juvenile PsA buff.ly/5zhbQmj https://buff.ly/5zhbQmj

28 Sep 2026 16:01 +0000

J&J announced topline results of Phase 4 STAR study where guselkumab (Tremfya) improved in axial Sxs & MRI outcomes in 411 biologic-naïve axial PsA pts, STAR is a 24 wk DBPCT of GUS (IL-23 inhib) in DMARD unresponsive pts. Endpoint was BASDAI @ wk24. buff.ly/tK6Q57c https://buff.ly/tK6Q57c

28 Sep 2026 15:00 +0000

Gabapentin Use Rose as Restrictions Fell, Study Shows Gabapentin use jumped quickly in Michigan after the drug was removed from the state's controlled substance schedule in 2024, a cross-sectional study showed. buff.ly/Czoe2Oq

28 Sep 2026 14:01 +0000

Residual steroids doesnt preserve remission. Japan FRANK #RA registry 411/3,863 were in Boolean remission - 130 on GC vs 231 non-GC (1/3 on b/tsDMARDs). Roughly 1/3 flared to LDA @12 mos. Outcomes same for GC vs non-GC Rx pts. buff.ly/ZPnGGqf

27 Sep 2026 21:07 +0000

FDA has approved baricitinib (Olumiant) for the treatment of pediatric patients 12 years of age and older with severe alopecia areata buff.ly/BjKSDs2 https://buff.ly/BjKSDs2

27 Sep 2026 20:00 +0000

Cluster analysis of Spanish RELES #SLE SLE cohort reveals 3 groups. C1 (n 168) was younger, w/ lupus nephritis, low C3, intensive Rx, high infx & damage. C2 (175) w/ cytopenias, serositis, APL & dsDNA(+). C3 (452) mild skin-Jts, less serologic activity & complications buff.ly/Oj3vuij

27 Sep 2026 18:00 +0000

Prescribing New GLP-1-Based Therapies buff.ly/strzaZX

27 Sep 2026 16:01 +0000

Systematic review 14 studies assessed Lung ultrasound (LUS) (vs HRCT) to detect RA-ILD (using threshold of ≥ 5 B-lines) found sensitivity was 86.8% (95% CI 80.1–91.4), specificity 75.4% (95% CI 62.3–85.1), and AUC 0.890 buff.ly/7rE7jqd

27 Sep 2026 14:02 +0000

Study of 119 Rheum pts on GLP-1 Rx (65% T2DM, 35% obesity; mean BMI 35). @ 12 mos wt loss −7.7 kg & 56% improved ≥1 BMI category. Signif decr in A1c, FBS, lipids, LDL, TG, ESR & CRP. GLP-1RAs useful cardiometabolic benefits buff.ly/pGQpIDB~

25 Sep 2026 15:00 +0000

Do You Have to be Overweight for GLP-1s to Work? buff.ly/z5mLbOO

25 Sep 2026 14:00 +0000

TNR: Obesity Treatment & Safety buff.ly/ekuQViw

24 Sep 2026 23:00 +0000

FDA FAERS pharmacovigilance study of MSK serious adverse reports w/ GLP-1 RAs - Muscle atrophy showed the strongest AE, w/ less freq reports of back pain, muscle spasms, neck pain. buff.ly/7bAa0wv https://buff.ly/7sii6lW

24 Sep 2026 18:00 +0000

2024 death rates from unintentional falls among adults≥65 yrs were 74.8/100K for men (66.6 women) Rates were higher for men > women. Fall death rates incr w/ age: highest ≥85 years. buff.ly/OTJQQ2f

24 Sep 2026 16:00 +0000

Prescribing New GLP-1-Based Therapies buff.ly/strzaZX