We use T. brucei to study the role of chromatin and genome architecture in antigenic variation. https://www.vetmed.lmu.de/molpara/en/https://bsky.app/profile/siegel-lab.bsky.socialhttps://bsky.app/profile/siegel-lab.bsky.social/post/3mgcwaijljc2tCongratulations! [contains quote post or other embedded content]05 Mar 2026 13:38 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3mgcwaijljc2thttps://bsky.app/profile/siegel-lab.bsky.social/post/3melg6mer7c2zCongratulations! It's great to have you working with us. Many thanks also to the @ec.europa.eu for the funding and to the anonymous reviewers for supporting Belén's ambitious project. [contains quote post or other embedded content]11 Feb 2026 11:54 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3melg6mer7c2zhttps://bsky.app/profile/siegel-lab.bsky.social/post/3lua4nsz3ek2lWe’re very excited about the potential of IACS for advancing infectious disease research and believe this review from the Goda lab and its collaborators in @natrevbioeng.nature.com highlights its many powerful applications. Check out the full paper here: https://www.nature.com/articles/s44222-025-00334-118 Jul 2025 09:21 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3lua4nsz3ek2lhttps://bsky.app/profile/siegel-lab.bsky.social/post/3lsbn34uemc25We’re excited to share our review: "Next-generation genetic screens in kinetoplastids", now published in NAR! It covers a range of perturbation methods—from RNAi to prime editing—as well as emerging assay technologies like scRNA-seq and image-activated cell sorting. https://academic.oup.com/nar/article/53/11/gkaf515/816679123 Jun 2025 12:57 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3lsbn34uemc25https://bsky.app/profile/siegel-lab.bsky.social/post/3loh37ybsqc2mVery much looking forward to it. [contains quote post or other embedded content]05 May 2025 19:13 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3loh37ybsqc2mhttps://bsky.app/profile/siegel-lab.bsky.social/post/3lltg5futrk2cGreat work. [contains quote post or other embedded content]02 Apr 2025 12:45 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3lltg5futrk2chttps://bsky.app/profile/siegel-lab.bsky.social/post/3lk6yyc2gs22vIf you are interested in antigenic variation, you may have wondered how parasites ‘select’ which antigen to express next. Our manuscript, just published in Nature, provides some answers! https://www.nature.com/articles/s41586-025-08720-w @lmumuenchen.bsky.social @erc.europa.eu a.eu @nature.com12 Mar 2025 16:31 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3lk6yyc2gs22vhttps://bsky.app/profile/siegel-lab.bsky.social/post/3li4ynj5kfs2sHope we can join this meeting again this year. [contains quote post or other embedded content]14 Feb 2025 10:29 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3li4ynj5kfs2shttps://bsky.app/profile/siegel-lab.bsky.social/post/3lfv4awk5322dI’m very much looking forward to attending the symposium and to celebrate the career of Mark Carrington. [contains quote post or other embedded content]16 Jan 2025 20:22 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3lfv4awk5322dhttps://bsky.app/profile/siegel-lab.bsky.social/post/3lfpjnaji4s2tThat is why we left. [contains quote post or other embedded content]14 Jan 2025 15:06 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3lfpjnaji4s2thttps://bsky.app/profile/siegel-lab.bsky.social/post/3lec6fek4g22dOur paper is out! We used Micro-C to study the 3D genome organization at high resolution in trypanosomes and revealed an extensive network of inter-chromosomal transcription hubs. read more at https://doi.org/10.1038/s41467-024-55285-9 🧬 Great work from @claudiarabu.bsky.social @naturecomms.bsky.social27 Dec 2024 14:15 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3lec6fek4g22dhttps://bsky.app/profile/siegel-lab.bsky.social/post/3ldob3gcp6222Great work [contains quote post or other embedded content]19 Dec 2024 16:09 +0000at://did:plc:lafmjynps73p2pxsmgl5evwq/app.bsky.feed.post/3ldob3gcp6222