GRA Eminent Scholar and Professor at University of Georgia. Into Systems Biology, genome editing, cell-cell interactions, glycobiology, metabolism, biologics, and lots of other cool science stuff. Http://lewis.uga.eduhttps://bsky.app/profile/natelewis3.bsky.socialhttps://bsky.app/profile/natelewis3.bsky.social/post/3muo5jue57s2kHooman Hefzi (DTU), a Prior student of mine, is running a really cool mammalin syn/sysbio lab now. He's hiring systems and structural bio postdoc now. https://efzu.fa.em2.oraclecloud.com/hcmUI/CandidateExperience/da/sites/CX_2001/job/782304 Sep 2026 04:40 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3muo5jue57s2khttps://bsky.app/profile/natelewis3.bsky.social/post/3mpib4dntxk2zIt took several years, but @hmbaghdassarian.bsky.social got it working... genome scale models of human metabolism, transcription, translation, and protein secretion (ME+secretion model). Check out the preprint! https://www.biorxiv.org/content/10.64898/2026.05.30.728988v1.full30 Jun 2026 05:22 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3mpib4dntxk2zhttps://bsky.app/profile/natelewis3.bsky.social/post/3mpia7hqpy22zOur recent work mapping out the protein-protein interactions with IL-2 before and after T-cell stimulation. https://pubs.acs.org/doi/full/10.1021/acs.analchem.5c0560230 Jun 2026 05:06 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3mpia7hqpy22zhttps://bsky.app/profile/natelewis3.bsky.social/post/3mlelimy6yc2uHad fun annotating glycopeptides from DIA-MS glycoproteomics by looking at similar MS spectra, glycan biosynthetic pathways. Awesome collaboration with Alejandro Gomez Toledo and Johan Malmström from Lund Univ and James Sorrentino in my lab. #glycotime https://doi.org/10.1080/19420862.2026.266587908 May 2026 20:37 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3mlelimy6yc2uhttps://bsky.app/profile/natelewis3.bsky.social/post/3mjpsbfjnws2xWhy do some cells produce more protein than others? Jasmine Tat (UCSD & Amgen) conducted a detailed study into the single-cell transcriptome, while measuring mAb production in single cells too with SEC-seq. Check out the preprint! https://doi.org/10.64898/2026.04.14.71827017 Apr 2026 20:47 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3mjpsbfjnws2xhttps://bsky.app/profile/natelewis3.bsky.social/post/3mjkcfjjquc2xOur team of ~50 researchers built a major update on the CHO genome-scale metabolic model. This includes 3D enzyme structures, and it helped us understand better how cells suppress glucose catabolism when the Warburg metabolism is suppressed. https://authors.elsevier.com/a/1mxeh8YyDfyNIs15 Apr 2026 16:20 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3mjkcfjjquc2xhttps://bsky.app/profile/natelewis3.bsky.social/post/3mgsrhnukgc2xCongrats to Dr. Jasmine Tat, who proved that a great PhD thesis is possible while conducting her research while working in industry. 1 great paper in Cell Systems, and more innovative ones coming soon! If only I could have convinced her to obey the sign behind her. https://doi.org/10.1016/j.cels.2025.10145311 Mar 2026 20:55 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3mgsrhnukgc2xhttps://bsky.app/profile/natelewis3.bsky.social/post/3mfqcuuuokc2dCheck out our latest work on inferring metabolite-protein-mediated cell-cell communication. Led by @erickarmingol.bsky.social https://doi.org/10.1093/bioinformatics/btaf66726 Feb 2026 04:03 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3mfqcuuuokc2dhttps://bsky.app/profile/natelewis3.bsky.social/post/3m7nt7tilak2f~1/3 of protein-coding genes are made in the secretory pathway. We curated >1000 of its machinery proteins, opening up new opportunities to engineer cells for drug production, to study cell-cell interactions, or modeling. @cp-cellsystems.bsky.social paper -> https://authors.elsevier.com/a/1mFMc8YyDfuZjq10 Dec 2025 19:47 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3m7nt7tilak2fhttps://bsky.app/profile/natelewis3.bsky.social/post/3m73eeslals2kCongrats to Mina Wu for an excellent PhD defense on improving production of mAbs and vaccine proteins by studying protein-protein interactions in the production cells. See https://doi.org/10.1002/biot.70112 and https://doi.org/10.1016/j.ymben.2025.07.00603 Dec 2025 11:33 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3m73eeslals2khttps://bsky.app/profile/natelewis3.bsky.social/post/3m67d3ce4ck27Got a great score for a vaccine proposal and yet fearful about if it will be funded. Maybe my next proposal will fare better? "Intersectional Bias, Woke Adjuvants, and Inclusive Nanoparticle Vaccines: Disinformation-Resilient Immunity in Trans-genic Mice and Women". Fundable?22 Nov 2025 07:55 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3m67d3ce4ck27https://bsky.app/profile/natelewis3.bsky.social/post/3m4xyzgcctk27Looking forward to this collaboration with Ginkgo https://www.genengnews.com/topics/bioprocessing/ginkgo-bioworks-awarded-project-agreement-through-bardas-biomap-consortium/06 Nov 2025 16:42 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3m4xyzgcctk27https://bsky.app/profile/natelewis3.bsky.social/post/3m3un7pwjcs2g😭 [contains quote post or other embedded content]23 Oct 2025 15:07 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3m3un7pwjcs2ghttps://bsky.app/profile/natelewis3.bsky.social/post/3m3hseymkc22aI love this visual of what I've been telling my kids / students, but I add that immediate answers rob our creativity too. I regularly ask myself "i can prompt this, but how important will my struggle be here?" Some tasks are perfect for AI. For others I choose to stimulate creativity & learning. [contains quote post or other embedded content]18 Oct 2025 12:35 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3m3hseymkc22ahttps://bsky.app/profile/natelewis3.bsky.social/post/3m34qak7qmc2uWhy do some recomb proteins express better than others? After expressing >2000 proteins from the human secretome in CHO cells, we identified the protein features and host cell pathways linked to poor expression w/ @JohanRockberg lab. https://www.pnas.org/doi/abs/10.1073/pnas.250603612214 Oct 2025 02:57 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3m34qak7qmc2uhttps://bsky.app/profile/natelewis3.bsky.social/post/3m2zj2moxak2bRobert Francis Kennedy Junior [contains quote post or other embedded content]12 Oct 2025 20:11 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3m2zj2moxak2bhttps://bsky.app/profile/natelewis3.bsky.social/post/3lwy4kazwyc2yHonored to have our recent work on mapping out the cell machinery regulating protein secretion highlighted at GEN https://www.genengnews.com/topics/bioprocessing/mapping-out-the-everything-of-protein-secretion/22 Aug 2025 09:14 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3lwy4kazwyc2yhttps://bsky.app/profile/natelewis3.bsky.social/post/3lre5apth3224Excitng collaboration in which we expressed a hepatitis c vaccine candidate in a panel of glycoengineered CHO cell lines. This allowed us to find a specific glycan structure that greatly improved immunogenecity, even for more distant strains #glycotime https://www.nature.com/articles/s41541-025-01161-611 Jun 2025 19:27 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3lre5apth3224https://bsky.app/profile/natelewis3.bsky.social/post/3lk7kx7vfg227While our first discovery of this occurred just weeks into the shutdown, it's great to see it off bioRxiv now. SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. Great collab with Knight and Esko labs and many others #glycotime https://journals.asm.org/doi/10.1128/mbio.04015-2412 Mar 2025 21:52 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3lk7kx7vfg227https://bsky.app/profile/natelewis3.bsky.social/post/3lhaoykbbr222Took me a while to get the new uga address, but my lab website is finally live. lewislab.uga.edu03 Feb 2025 04:22 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3lhaoykbbr222https://bsky.app/profile/natelewis3.bsky.social/post/3lhaoaqdtpc22With all of the US government science chaos going on, I'm curious if anyone knows which governments are seeing the great opportunity to recruit top labs and tech companies, to bolster their international presence, and to reverse the brain drain.03 Feb 2025 04:09 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3lhaoaqdtpc22https://bsky.app/profile/natelewis3.bsky.social/post/3lfpjl7tdyc26I don't think that 101 years ago, Otto Warburg was aware how broadly relevant his discovery was. Check out our new paper out today in Nature Metabolism, wherein we engineered the Warburg effect out of mammalian cells to improve biologics production https://urldefense.com/v3/__https://links.springernature.com/f/a/WHpn_uhYhCtwcpAnLgDasA**A/AABE5gA*/RgRpaOVZP0SjaHR0cHM6Ly93d3cubmF0dXJlLmNvbS9hcnRpY2xlcy9zNDIyNTUtMDI0LTAxMTkzLTc_dXRtX3NvdXJjZT1yY3RfY29uZ3JhdGVtYWlsdCZ1dG1fbWVkaXVtPWVtYWlsJnV0bV9jYW1wYWlnbj1ub25vYV8yMDI1MDExNCZ1dG1fY29udGVudD0xMC4xMDM4L3M0MjI1NS0wMjQtMDExOTMtN1cDc3BjQgpnf1lghmfvTSPRUhJubGV3aXNyZXNAdWNzZC5lZHVYBAAABy0*__;fn5-fg!!Mih3wA!HJBWCrTDXQguQ-ci8sxGI0qX1dXYdy7JPZc-8GkMSxPf6gr0yMKmWt-_c-wWOl0JDZQrFDrtnGWQzxn-VsWO$14 Jan 2025 15:04 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3lfpjl7tdyc26https://bsky.app/profile/natelewis3.bsky.social/post/3kjgdz6loic2iThese past few years have seen a rapid expansion of cell-cell communication research. Check out our new review of the diverse methods leveraging single-cell and spatial omics: rdcu.be/dwkND20 Jan 2024 15:45 +0000at://did:plc:mrrgj2sei2a4yiboutpcrdyl/app.bsky.feed.post/3kjgdz6loic2i