Protein Biochemist. Structural Biology. Cardiac arrhythmias. Muscle excitation-contraction coupling. MTB and road biking. Music arrangements. https://www.vanpetegemlab.comhttps://bsky.app/profile/filipvanpetegem.bsky.socialhttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3mejupsows227Citation nonsense. Our paper on Ryanodine Receptor disease mutations gets cited in a paper about nanocellulose... https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/adfm.202523000 Journals could use an AI tool to weed through irrelevant citations. Or is this entire paper an AI hallucination?10 Feb 2026 21:09 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3mejupsows227https://bsky.app/profile/filipvanpetegem.bsky.social/post/3m6kgbvxjds2pThanks to the UBC media team for coverage of our statin : RyR1 work. Atorvastatins bind and trigger opening of a calcium release channel critical for muscle contraction. https://news.ubc.ca/2025/11/ubc-statins-muscles-research/ @ubcmedicine.bsky.social26 Nov 2025 17:52 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3m6kgbvxjds2phttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3m65wq42h6s2oOur latest work : Statins are used to lower plasma cholesterol but often come with muscle-related side effects. Using cryo-EM, we show how multiple statin molecules cooperate to bind RyR1, a calcium release channel mainly found in skeletal muscle. https://nature.com/articles/s41467-025-6652221 Nov 2025 18:42 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3m65wq42h6s2ohttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3m2ms2m4mos2hVery interesting paper from Susan Hamilton's lab, showing that phosphorylation of RyR1 by SPEG kinase can suppress pathological consequences of disease mutations. https://www.science.org/doi/10.1126/scisignal.adx308707 Oct 2025 18:47 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3m2ms2m4mos2hhttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3m2cpziughs2nOur cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD https://www.nature.com/articles/s41467-025-64060-303 Oct 2025 18:44 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3m2cpziughs2nhttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3lqk54kmcq22ehttps://www.science.org/doi/10.1126/sciadv.adt9799 A study in collaboration with Frank Bosmans. Reproducible protocol to measure the elusive NaV1.9 currents, and revealing a big role for the preIQ region in gating properties.01 Jun 2025 11:15 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3lqk54kmcq22ehttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3lk4jwvh6z22cStill a few days left to apply for a faculty position focused on cardiac arrhythmias at Simon Fraser University. Come join the greater Vancouver network on arrhythmia research! https://www.academicwork.ca/jobs/assistant-or-associate-professor-in-cardiac-arrhythmias-simon-fraser-university11 Mar 2025 16:56 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3lk4jwvh6z22chttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3lje2t5umys2zIs it just me or is Pubmed down...??01 Mar 2025 23:22 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3lje2t5umys2zhttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3lc4jltuyjk2yStress in action: our crystal structure of PKA bound to its preferred substrate in CaV1.2 (Ser1981 for the aficionados). Quantitative experiments on previously proposed sites in CaV1.2 and its regulator Rad shows that there are two tiers of substrates. https://jbc.org/article/S0021-9258(24)02541-9/fulltext29 Nov 2024 21:29 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3lc4jltuyjk2yhttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3lbnjocdotc22Calcins are scorpion-derived peptides that can cross the plasma membrane and modulate the Ryanodine Receptor. Marvin presenting the latest cryoEM results from our lab at the 2024 Translational Arrhythmia Day (TADA) meeting. (description also here: https://www.science.org/doi/10.1126/sciadv.adf4936)23 Nov 2024 22:20 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3lbnjocdotc22https://bsky.app/profile/filipvanpetegem.bsky.social/post/3laouil3yik2cEvery day since the late 1920s (except during WWII), the notes of the Last Post sound through the Menin Gate in Ypres, Belgium. Unfortunately, "never again" hasn't stuck. #ArmisticeDay11 Nov 2024 17:41 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3laouil3yik2chttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3lajy4gzv5c2jCan you find out which ion binds your protein using cryo-EM? This new method from Bonnie Murphy's lab combines electron energy loss spectroscopy and single particle imaging, showing this can become posssible. Test case on our favorite protein, the Ryanodine Receptor. https://www.nature.com/articles/s41592-024-02482-509 Nov 2024 19:03 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3lajy4gzv5c2jhttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3l5qeq2zwla2tOur latest cryo-EM study, elucidating the type 3 Ryanodine Receptor (RyR3) in different conformational states nature.com/articles/s4146… Unexpected binding sites for ATP and chloride in the N-terminal region, affected by mutations linked to epileptic encephalopathy. https://nature.com/articles/s4146…05 Oct 2024 03:49 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3l5qeq2zwla2thttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3kqdyvlxuu52eA new faculty position in cardiac arrhythmia in the greater Vancouver area. https://sfu.ca/content/dam/sfu/bpk/bpk/docs/stem%20cell%20job%20ad%20April%204%20final%20version.pdf Come join our local arrhythmia community.17 Apr 2024 19:18 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3kqdyvlxuu52ehttps://bsky.app/profile/filipvanpetegem.bsky.social/post/3kjjf2jmqwd2pA very cool method by Bonnie Murphy's lab to map elements for cryo-EM. The method, named REEL-EM, makes use of electron-energy loss spectroscopy. Honored to have contributed to this: https://www.biorxiv.org/content/10.1101/2024.01.18.575858v121 Jan 2024 20:42 +0000at://did:plc:mvklbfbjmw6k3szomtwvbk3e/app.bsky.feed.post/3kjjf2jmqwd2p