Lab news and updates for the Emmott lab, RNA virology & proteomics at the Centre for Proteome Research, University of Liverpool, UK Lab website: emmottlab.orghttps://bsky.app/profile/emmottlab.bsky.socialhttps://bsky.app/profile/emmottlab.bsky.social/post/3mi6wrucza22xMSCA Postdoctoral Fellowships call opening soon. If you are a strong candidate and interested in submitting a fellowship with us, we have opportunities in several areas of virology/proteomics. See emmottlab.org Call details/eligibility: https://marie-sklodowska-curie-actions.ec.europa.eu/funding/msca-postdoctoral-fellowships-202629 Mar 2026 10:27 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3mi6wrucza22xhttps://bsky.app/profile/emmottlab.bsky.social/post/3mhhplpiips2qNew preprint! Current T7-based MNV reverse genetics can be performed by co-transfecting plasmids encoding T7 RNA polymerase and vaccinia capping enzymes. We see a further 100-1000-fold boost in titres by incorporating CD300lf-expressing BSR-T7 cells into this system. https://www.biorxiv.org/content/10.64898/2026.03.19.712921v120 Mar 2026 04:47 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3mhhplpiips2qhttps://bsky.app/profile/emmottlab.bsky.social/post/3mfjpjswjvc25Funded PhD studentship (UK students only) available on clinical proteomics, application deadline 22nd March for Oct 2026 start! This project seeks to understand treatment responses to exacerbations experienced by people with CF using proteomics. https://www.findaphd.com/phds/project/proteomic-signatures-of-treatment-response-during-pulmonary-exacerbations-in-cystic-fibrosis/?p19490023 Feb 2026 13:01 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3mfjpjswjvc25https://bsky.app/profile/emmottlab.bsky.social/post/3me7layavos2hCongrats to Dr @stephenholmes.bsky.social on passing his PhD viva today! Thanks to examiners Al Darby and @mtrost.bsky.social!06 Feb 2026 18:53 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3me7layavos2hhttps://bsky.app/profile/emmottlab.bsky.social/post/3m7q4ur77ek2bFor those who missed the British science festival in September, the recordings and mini documentary for antiviral roller skating are now out! [contains quote post or other embedded content]11 Dec 2025 17:45 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3m7q4ur77ek2bhttps://bsky.app/profile/emmottlab.bsky.social/post/3m7cv4evybs2xAnother new preprint! This time looking at flavivirus NS5 interactions with our collaborator Armando Arias - https://www.biorxiv.org/content/10.64898/2025.12.05.692556v106 Dec 2025 11:21 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3m7cv4evybs2xhttps://bsky.app/profile/emmottlab.bsky.social/post/3m72reacu2s2tNew preprint from the lab, and joint first authors @biomarkella.bsky.social and @stephenholmes.bsky.social! Single-cell phenotypic analysis and multiplet detection through incorporation of microscopy data into cellenONE-based single-cell proteomic data analysis https://www.biorxiv.org/content/10.64898/2025.12.01.691577v103 Dec 2025 05:53 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3m72reacu2s2thttps://bsky.app/profile/emmottlab.bsky.social/post/3m6gta4kunk22New preprint: Viral protease-mediated polyprotein processing in human astroviruses Great collaboration with Lulla lab. And the first of @leandroxneves.bsky.social proteolysis stories. More coming soon! https://www.biorxiv.org/content/10.1101/2025.11.24.690148v125 Nov 2025 07:33 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3m6gta4kunk22https://bsky.app/profile/emmottlab.bsky.social/post/3m5waeyezt22dNew preprint: IFIT3 controls IFIT1 accumulation and specificity preventing self mRNA targeting during the innate immune response. https://www.biorxiv.org/content/10.1101/2025.11.17.688928v1 Led by Renata Fleith from the Sweeney lab.18 Nov 2025 17:13 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3m5waeyezt22dhttps://bsky.app/profile/emmottlab.bsky.social/post/3m4pgkcefs22qFunded PhD opportunity through the DiMeN DTP: studying HEV proteolysis. You’ll be primarily based in the Herod lab at Leeds, and work with us on the use of MS-based proteomics to study proteolysis! https://www.findaphd.com/phds/project/mrc-dimen-doctoral-training-partnership-molecular-regulation-of-proteolysis-by-hepatitis-e-virus-as-a-basis-for-therapeutic-intervention/?p18940303 Nov 2025 06:50 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3m4pgkcefs22qhttps://bsky.app/profile/emmottlab.bsky.social/post/3lyeresljrs2bThe lab is being represented at the IX International Calicivirus Conference in Banff by @tartanvirus.bsky.social! Catch Frazer to talk protease substrates and proteomics.09 Sep 2025 03:23 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3lyeresljrs2bhttps://bsky.app/profile/emmottlab.bsky.social/post/3lx5lpmk7s22cLed by @idb-virology.bsky.social, the lab is contributing to #BSF25 with a performance of antiviral roller skating! Working with Liverpool roller birds, and supported by the BSF and @microbiologysociety.org [contains quote post or other embedded content]24 Aug 2025 13:28 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3lx5lpmk7s22chttps://bsky.app/profile/emmottlab.bsky.social/post/3lx2mekifes2yNew paper: collaboration with Cambridge on EMCV 2B* now published https://journals.asm.org/doi/10.1128/mbio.01008-2523 Aug 2025 09:02 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3lx2mekifes2yhttps://bsky.app/profile/emmottlab.bsky.social/post/3lsl5smd75k2bThe lab got a nice bit of news yesterday! LEAF gold!27 Jun 2025 07:51 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3lsl5smd75k2bhttps://bsky.app/profile/emmottlab.bsky.social/post/3lpxy3rkibk2pWe have projects available on single-cell proteomics, including methods development, and applications to antiviral development and resistance. If you have a strong background in proteomics and are considering an MSCA, get in touch! https://marie-sklodowska-curie-actions.ec.europa.eu/news/msca-opens-eu4043-million-call-for-postdoctoral-fellowships25 May 2025 05:57 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3lpxy3rkibk2phttps://bsky.app/profile/emmottlab.bsky.social/post/3lgglqyb6bk2eFirst 2025 paper: delighted to have contributed to this paper on the emergence of a new subgenomic mRNA in SARS-CoV-2 from the Bauer lab https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.300298223 Jan 2025 19:15 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3lgglqyb6bk2ehttps://bsky.app/profile/emmottlab.bsky.social/post/3lf5ihlxow223Another PhD studentship is available for Oct 2025 start! In a collaboration between the @pirbrightinst.bsky.social and us, you will be investigating the role of novel avian coronavirus accessory genes. See here for more details! https://www.findaphd.com/phds/project/investigation-of-novel-accessory-proteins-in-the-replication-of-infectious-bronchitis-virus/?p181241 Deadline 17 Feb, funded for UK only.07 Jan 2025 10:57 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3lf5ihlxow223https://bsky.app/profile/emmottlab.bsky.social/post/3ldjkfgzrkc2nThe deadlines for our MRC-funded studentships have now passed, but a funded studentship through the BBSRC NWD DLA is now available for Oct 2025 start in single cell mass spectrometry. See findaphd for more details or drop Ed an email. https://www.findaphd.com/phds/project/bbsrc-nwd-case-expanding-single-cell-proteomics-into-single-cell-multi-omics/?p18025717 Dec 2024 19:13 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3ldjkfgzrkc2nhttps://bsky.app/profile/emmottlab.bsky.social/post/3lbju7iznfk2lReminder - if you are a new PI in UK virology and you aren’t yet registered for RIVR2025 on Jan9-10th in Liverpool, registration closes on December 5th! If you are a new group leader in virology in the UK and aren’t yet on the RIVR mailing list, get in touch to be added.22 Nov 2024 11:18 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3lbju7iznfk2lhttps://bsky.app/profile/emmottlab.bsky.social/post/3la45m2rtdg2vWe have two funded PhD studentships available through DiMeN_DTP programme for Oct2025 Standard_2025_127: Understanding the mechanisms of norovirus replication (Dr Edward Emmot) Standard_2025_71: Widening the ‘NET’ to identify new treatments for bronchiectasis (Dr Helen Wright)04 Nov 2024 07:04 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3la45m2rtdg2vhttps://bsky.app/profile/emmottlab.bsky.social/post/3kqmwgv7lds2yJust to warn we do not have any positions available in our lab- some fraudulent adverts are being circulated on LinkedIn and possibly elsewhere - the link to the lab website is real but all the links below and the details are all fake.21 Apr 2024 08:28 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3kqmwgv7lds2yhttps://bsky.app/profile/emmottlab.bsky.social/post/3kkoo4o7o5d2wNew paper: Porcine Sapovirus Protease Controls the Innate Immune Response and Targets TBK1. Work led by Ileana Georgana from the Goodfellow lab https://www.mdpi.com/1999-4915/16/2/24705 Feb 2024 16:33 +0000at://did:plc:mxr3pb2trwfgthvrgahe53bi/app.bsky.feed.post/3kkoo4o7o5d2w