Margolis Lab | NYU Pain Research Center 🧠💩 Discovering how gut signaling impacts brain & GI disorders. Exploring the role of serotonin in gut-brain interaction, DGBI, neurodevelopmental disorders, and visceral pain. PI: @karapedsgastrodoc.bsky.socialhttps://bsky.app/profile/margolislabnyu.bsky.socialhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3moj4xdcofs2u🎉 Congratulations to Chalystha and Rahi from the Margolis Lab on their achievements at the 2026 Annual Molecular Pathobiology Innovative Research Symposium (AMPIRS)! Chalystha won 3rd Place for her 3-minute flash talk Rahi won 3rd Place for her poster presentation @karapedsgastrodoc.bsky.social17 Jun 2026 20:16 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3moj4xdcofs2uhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mmzbfdhf4c2zConGRADulations, Mariam! 🎓 It has been a pleasure having Mariam in the Margolis Lab through NYU Dentistry's TRIP&ICE program. We are so proud of all she has accomplished and wish her the very best in her next chapter! @karapedsgastrodoc.bsky.social @chalysthalee.bsky.social29 May 2026 19:27 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mmzbfdhf4c2zhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mmzapk26ps2zMore highlights from our amazing team at the NYU Pain Research Center Symposium! We're proud of our team's contributions and grateful for a fantastic day of science, collaboration, and discovery.29 May 2026 19:15 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mmzapk26ps2zhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mmzaodfy4s2zThe Margolis Lab was proud to be represented by six poster presenters at the 2026 Pain Research Center Symposium! Congratulations to: Sarah, Daniel, Chalystha, Lin, Rahi, Taeseon Great job to everyone who presented and contributed to a fantastic day of science! @karapedsgastrodoc.bsky.social29 May 2026 19:14 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mmzaodfy4s2zhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mmzamc2alc2zHighlights from the 2026 Pain Research Center Symposium! Dr. Kara Margolis presented: “Compartmental Serotonergic Signaling in Gut–Brain Health: Clinical Implications for Mood and Abdominal Pain” Thanks to everyone for a great day of science! @karapedsgastrodoc.bsky.social29 May 2026 19:13 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mmzamc2alc2zhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mm5gt2ellc2fCongratulations to Haoming on graduating from New York University with a Master of Science in Biology from the Graduate School of Arts and Sciences! 🎓✨ Wishing you all the best in your next chapter, we’re so proud of you! @karapedsgastrodoc.bsky.social18 May 2026 17:50 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mm5gt2ellc2fhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3miwmiw7zo222New data from the Julius Lab show that crosstalk between epithelial tuft cells and enterochromaffin cells drives a gut-brain signal that turns parasite sensing into appetite suppression. Cool stuff! @karapedsgastrodoc.bsky.social https://www.nature.com/articles/s41586-026-10281-507 Apr 2026 20:27 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3miwmiw7zo222https://bsky.app/profile/margolislabnyu.bsky.social/post/3mijttintfc2oIn our latest study, we explore how early experiences can shape gut function and pain later in life. Dr. @sarahanajjar.bsky.social breaks it down 👇02 Apr 2026 18:34 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mijttintfc2ohttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mijfakvf6k2oDr. Lin Hung from our lab received the 2026 American Gastroenterological Association Research Scholar Award for her project on linking GI-derived oxytocin and serotonin to treat DGBI pain. This prestigious award supports early-career researchers pursuing independent careers in digestive diseases.02 Apr 2026 14:13 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mijfakvf6k2ohttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mihhnqtoj22aWe’re excited to launch a new series of posts and videos from the Margolis Lab 🎥 Stay tuned.👀 Our first video drops tomorrow! Dr.@sarahanajjar.bsky.social will be sharing insights on our newly published paper. @karapedsgastrodoc.bsky.social01 Apr 2026 19:51 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mihhnqtoj22ahttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mhbtkoezcs25New from our lab: Untreated maternal depression & early-life stress can rewire gut–brain circuits via enteric + sympathetic pathways, leading to long-term changes in gut motility & pain. https://www.sciencedirect.com/science/article/pii/S0016508526002052 @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social17 Mar 2026 20:42 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mhbtkoezcs25https://bsky.app/profile/margolislabnyu.bsky.social/post/3mh7d4lcezs2dAmazing new article from the Thaiss and Levy labs! These data show that gut microbes drive age-related memory loss by disrupting gut-brain signaling. @christophthaiss.bsky.social @maayanlevy.bsky.social @karapedsgastrodoc.bsky.social https://www.nature.com/articles/s41586-026-10191-616 Mar 2026 20:43 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mh7d4lcezs2dhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mgpxvbyblk2jChronic inflammation in IBD reshapes the stem cell niche—reducing LGR5⁺ stem cells while expanding OLFM4⁺ immune-responsive populations, revealing epithelial plasticity. @karapedsgastrodoc.bsky.social https://www.biorxiv.org/content/10.64898/2025.12.11.691866v210 Mar 2026 18:12 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mgpxvbyblk2jhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mgnbwgmcdk2eAnother promising finding for 5HT4R agonism! This study found that in participants with previous episodes of depression, 5-HT4R agonist, prucalopride, had pro-cognitive effects (learning, memory & attention). @karapedsgastrodoc.bsky.social https://doi.org/10.1016/j.nsa.2025.10654909 Mar 2026 16:34 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mgnbwgmcdk2ehttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mgnbqdikjs2eA large cohort study of 126,735 adults followed over 14.5 years show the high prevalence of IBS cases in instances of severe emotional and physical neglect, as well as abuse. @karapedsgastrodoc.bsky.social https://www.nature.com/articles/s41398-026-03833-w09 Mar 2026 16:30 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mgnbqdikjs2ehttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mgddrf3g322eA gut-acting 5-HT4 drug, prucalopride, shows faster antidepressant/anxiolytic effects than fluoxetine in mice, with parallel shifts in the microbiome. @karapedsgastrodoc.bsky.social https://www.nature.com/articles/s41522-026-00928-605 Mar 2026 17:40 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mgddrf3g322ehttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mgddahz4hc2eFood is more than fuel for growing bodies, it may shape developing minds. Higher ultraprocessed food intake in preschool years was associated with more behavioral and emotional symptoms in early childhood. @karapedsgastrodoc.bsky.social https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2845768?widget=personalizedcontent&previousarticle=283868805 Mar 2026 17:31 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mgddahz4hc2ehttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mgb5m34itk2bAmazing new study shows how pain-sensing nerves work together with tuft cells of the intestinal epithelium to protect the gut from infection. @karapedsgastrodoc.bsky.social https://www.nature.com/articles/s41586-025-09921-z04 Mar 2026 20:44 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mgb5m34itk2bhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mgb5h6zptc2bBalancing benefit and risk is key in IBS therapy. Quantifying the ‘number needed to harm’ helps clinicians better evaluate treatment safety. @karapedsgastrodoc.bsky.social https://pmc.ncbi.nlm.nih.gov/articles/PMC12940625/04 Mar 2026 20:42 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mgb5h6zptc2bhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mg6ex4dx4s2fGut health finally has a scientific definition. ISAPP’s new consensus defines it as normal GI function without disease or symptoms that affect quality of life. @karapedsgastrodoc.bsky.social https://www.nature.com/articles/s41575-026-01176-x03 Mar 2026 18:18 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mg6ex4dx4s2fhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mg6edbdagk2fThis cool new paper reports an important characterization of how enteroendocrine cells in the gut are positioned relative to sensory neurons. Not surprisingly, there are significant regional differences along the GI tract! @karapedsgastrodoc.bsky.social https://onlinelibrary.wiley.com/doi/10.1111/nmo.7022103 Mar 2026 18:07 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mg6edbdagk2fhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3mg6e6uavh22fInteresting preprint showing that the behavioral effects of lithium are mediated by the gut-brain axis! https://www.biorxiv.org/content/10.64898/2026.01.26.701868v1 @karapedsgastrodoc.bsky.social03 Mar 2026 18:04 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3mg6e6uavh22fhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3m6wpbykfu22xThis study maps distinct enteric neuron subtypes and shows how each shapes key intestinal functions, from fecal output to feeding. A big step forward in understanding gut–brain neural circuits. https://www.sciencedirect.com/science/article/pii/S0092867425012462 @karapedsgastrodoc.bsky.social01 Dec 2025 15:05 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3m6wpbykfu22xhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3m6ffwkttb62lEnteric Neurons Join the Dialogue on Pain! A recent study reveals that cholinergic circuits within the colon communicate through dorsal root ganglion (DRG) pathways, particularly following inflammation. 👉 https://www.cell.com/neuron/fulltext/S0896-6273(25)00748-224 Nov 2025 18:02 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3m6ffwkttb62lhttps://bsky.app/profile/margolislabnyu.bsky.social/post/3m5hdaupdy224🚨The NYU Pain Research Center (PRC) and Department of Molecular Pathobiology at NYU Dentistry are seeking Assistant or Associate Professors in the fields of chronic pain mechanisms, pain therapeutics, and related disciplines. More info and apply: apply.interfolio.com/176454 https://apply.interfolio.com/17645412 Nov 2025 18:55 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3m5hdaupdy224https://bsky.app/profile/margolislabnyu.bsky.social/post/3lz7oipqhjs2i 📢New paper in Nature Mental Health! Dr. @karapedsgastrodoc.bsky.social is co-author on a review exploring how the gut microbiota shapes mental health through the gut–brain axis.🧠 🔗 https://doi.org/10.1038/s44220-025-00498-019 Sep 2025 20:14 +0000at://did:plc:ndudsfjw4plbe4j3urpjtc7b/app.bsky.feed.post/3lz7oipqhjs2i