Group leader at IMBA at Vienna BioCenter. How do single cells decide what to become? What to do? When? Where? https://www.oeaw.ac.at/imba/groups/daan-de-groothttps://bsky.app/profile/dhdegroot.bsky.socialhttps://bsky.app/profile/dhdegroot.bsky.social/post/3mi4dc6n6xc25We're looking for people with a solid computational background (Math, Physics, Computer science, Computational Biology, etcetera) to dive into biology! Come study the physical principles of cell-fate decisions using Bayesian data analysis and biophysical modeling! [contains quote post or other embedded content]28 Mar 2026 09:33 +0000at://did:plc:nj3sj43deobg73kthyzyscjm/app.bsky.feed.post/3mi4dc6n6xc25https://bsky.app/profile/dhdegroot.bsky.social/post/3mdfvdrlrfs2zBig news! At least for me. I'll start building my own research group at the amazing IMBA in Vienna. Starting from single-cell omics data, we will develop computational tools and theoretical models to understand how single cells make decisions, in particular during development. I think that IMBA is [contains quote post or other embedded content]27 Jan 2026 13:44 +0000at://did:plc:nj3sj43deobg73kthyzyscjm/app.bsky.feed.post/3mdfvdrlrfs2zhttps://bsky.app/profile/dhdegroot.bsky.social/post/3mccmx3dows2fSome time ago, we showed that bacterial adaptation is aided a lot by phenotypes becoming increasingly unstable at slow growth (https://www.pnas.org/doi/10.1073/pnas.2211091120), but we didn't know what caused this phenomenon. Over the last years, others continued the search, and you can now read the results! [contains quote post or other embedded content]13 Jan 2026 13:11 +0000at://did:plc:nj3sj43deobg73kthyzyscjm/app.bsky.feed.post/3mccmx3dows2fhttps://bsky.app/profile/dhdegroot.bsky.social/post/3loqevgjixk2sOh yes, and check out my debut as a failed YouTuber. I'm really much more excited about this than I sound in the video, because look how nice our Bonsai-scout app actually works to explore the data! [contains quote post or other embedded content]09 May 2025 12:00 +0000at://did:plc:nj3sj43deobg73kthyzyscjm/app.bsky.feed.post/3loqevgjixk2shttps://bsky.app/profile/dhdegroot.bsky.social/post/3loqelwjwqc2sBonsai is out! Finally, we can visually explore high-dimensional data in a distortion-free way. Try it out! It works from scRNA-seq data (https://bonsai.unibas.ch/bonsai-scout/?dir=Cord_blood_cells_CITE-seq) up to football statistics (https://bonsai.unibas.ch/bonsai-scout/?dir=Football_statistics). 
Ever wondered why low-dimensional embeddings like t-SNE [contains quote post or other embedded content]09 May 2025 11:55 +0000at://did:plc:nj3sj43deobg73kthyzyscjm/app.bsky.feed.post/3loqelwjwqc2shttps://bsky.app/profile/dhdegroot.bsky.social/post/3lodeidasrc2aNew publication! We identify growth coupled sensitivity: a deceivingly simple mechanism that makes E. coli switch to the best sugar. We combined neat theory (due to @erikvannimwegen.bsky.social, and to which I contributed) with clean experiments (due to @thomasjulou.bsky.social and Theo Gervais). [contains quote post or other embedded content]04 May 2025 07:48 +0000at://did:plc:nj3sj43deobg73kthyzyscjm/app.bsky.feed.post/3lodeidasrc2a