Clinical psychologist, psychotherapist and Associate Professor in Psychiatry & Epidemiology @ Amsterdam UMC. Exploring the biological underpinnings of Depression & Anxiety and how to improve their treatment.https://bsky.app/profile/ymilaneschi.bsky.socialhttps://bsky.app/profile/ymilaneschi.bsky.social/post/3miw6dwt7ms2r📣 preprint: "The Metabolomic Signature of Stressful Life Events". With data on >5,500 observations from 2 🇳🇱 cohorts we identified a specific biological signature of major life events, highlighting the connection of #stress with somatic & mental #health. #Metabolomics #Epidemiology 🔗 bit.ly/4vf15Xp https://bit.ly/4vf15Xp07 Apr 2026 16:14 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3miw6dwt7ms2rhttps://bsky.app/profile/ymilaneschi.bsky.social/post/3mi4hilij6c2i📣 Preprint: "Symptom-specific genetics reveal heterogeneity within major depressive disorder" led by @goulaan.bsky.social. We used #genetics of individual #depression symptoms from the #BIONIC 🇳🇱 project to decompose #MDD. bit.ly/3Nt43qA http://bit.ly/3Nt43qA28 Mar 2026 10:48 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3mi4hilij6c2ihttps://bsky.app/profile/ymilaneschi.bsky.social/post/3mc7sutsxtk2yDelighted to share my second collaboration with @thementalelf.bsky.social In this piece, I discuss the study "An encompassing Mendelian randomization study of the causes and consequences of major depressive disorder" by @joellepasman.bsky.social et al. [contains quote post or other embedded content]12 Jan 2026 10:19 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3mc7sutsxtk2yhttps://bsky.app/profile/ymilaneschi.bsky.social/post/3m2oqpcdyms2fAnd now, a more comprehensive #openaccess edited volume 📚 on #Metabolic #Neuropsychiatry is available, capturing the collective work and reflections from the Ernst Strüngmann Forum. https://link.springer.com/book/10.1007/978-3-032-05630-6 [contains quote post or other embedded content]08 Oct 2025 13:28 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3m2oqpcdyms2fhttps://bsky.app/profile/ymilaneschi.bsky.social/post/3lw2hztxqac2yOur study in @JAMAPsych ja.ma/4lVx1eu Using 🧬 we found that disruptions in #energy pathways link to specific #MDD symptoms (⬆️ appetite & sleep). This suggests a #depression profile linked to #metabolic risk, opening doors to targeted treatments. #metabolicpsychiatry https://ja.ma/4lVx1eu10 Aug 2025 14:19 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3lw2hztxqac2yhttps://bsky.app/profile/ymilaneschi.bsky.social/post/3ltywqrcrck23🚨 Preprint Alert 🚨 "Major depression and atherosclerotic disease: linking shared genetics to pathways in blood, brain, heart, and atherosclerotic plaques. " 🧠🫀🩸 The title says it all. Great collaboration with @swvanderlaan.bsky.social . 📄 Read it here: bit.ly/4eTM8T2 https://bit.ly/4eTM8T215 Jul 2025 12:47 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3ltywqrcrck23https://bsky.app/profile/ymilaneschi.bsky.social/post/3lshew3u2xk2cIn May 2024, I joined an inspiring week at the Ernst Strüngmann Forum on #Metabolic #Neuropsychiatry. Our first outcome is now in Nature Mental Health: 🧠 A Perspective on energy metabolism in psychiatric disorders 🔗 https://www.nature.com/articles/s44220-025-00422-6 More to come in an upcoming volume—stay tuned!25 Jun 2025 19:47 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3lshew3u2xk2chttps://bsky.app/profile/ymilaneschi.bsky.social/post/3lrazyctvas2jNice reminder of our #PNIRS2025 symposium. @eimearfoley.bsky.social, Naoise Mac Giollabhui, @dpmoriarity.bsky.social (in cross-Atlantic telepathic connection) and I will wait for you tomorrow morning!10 Jun 2025 13:50 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3lrazyctvas2jhttps://bsky.app/profile/ymilaneschi.bsky.social/post/3lqkixcsqo22uLooking forward to connecting with colleagues at #PNIRS2025 in Bordeaux 🇫🇷. Don't miss our symposium "Dissecting Depression Heterogeneity along Immuno-Metabolic Pathways: Triangulating Evidence from Hierarchical-Phenotyping, Experimental and Genomic Methods" Time & Outline of the symposium ⬇️ [contains quote post or other embedded content]01 Jun 2025 14:47 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3lqkixcsqo22uhttps://bsky.app/profile/ymilaneschi.bsky.social/post/3liyni5wabs2kOur new study in Translational Psychiatry showed that acylcarnitines (involved in mitochondrial #energy production) were linked to the presence+severity of #depression. Bioenergetic pathways may open new avenues in psychiatry #MetabolicPsychiatry check the paper ➡️: rdcu.be/eaWoN https://rdcu.be/eaWoN25 Feb 2025 10:24 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3liyni5wabs2khttps://bsky.app/profile/ymilaneschi.bsky.social/post/3li7o3anfdk2gCountdown on for the annual @pnirs.bsky.social meeting in Bordeaux #PNIRS2025 . Very excited for our member sponsored symposium (June 11) with @eimearfoley.bsky.social and @dpmoriarity.bsky.social on #depression heterogeneity and #immunometabolic mechanisms See you in 🇫🇷15 Feb 2025 11:58 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3li7o3anfdk2ghttps://bsky.app/profile/ymilaneschi.bsky.social/post/3lhvrhd4jlk2mNew collaboration published in @brainbehavimm.bsky.social Analyses leveraging #genetic data highlighted the potential role of #metabolic alterations (e.g., dyslipidemia, dysglycemia) as mechanisms connecting #childhood maltreatment with psychiatric + somatic #multimorbidity. https://doi.org/10.1016/j.bbi.2025.01.02411 Feb 2025 13:32 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3lhvrhd4jlk2mhttps://bsky.app/profile/ymilaneschi.bsky.social/post/3ldlkof5ryk27"Immuno-metabolic #depression: from concept to implementation". Our new collaborative review is out in THE LANCET Regional Health - Europe. We reflected on the current standing of the immuno-metabolic depression concept and its potential value for clinical implementation bit.ly/4iAlVdL #openaccess https://bit.ly/4iAlVdL18 Dec 2024 14:23 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3ldlkof5ryk27https://bsky.app/profile/ymilaneschi.bsky.social/post/3lcmqiqw23k27It was a pleasure to contribute to @thementalelf.bsky.social. In my piece, I discuss findings from a recent study by Spiller et al. (JAMA Psychiatry) on the heterogeneity of symptom presentation in mental disorder diagnoses. [contains quote post or other embedded content]06 Dec 2024 08:15 +0000at://did:plc:olwnugtccvlua5c5rn4t4a23/app.bsky.feed.post/3lcmqiqw23k27