Online-only Nature Research journal that publishes basic, translational, clinical and public health research in cardiac, vascular and blood biology. https://www.nature.com/natcardiovascres/https://bsky.app/profile/natcardiovascres.nature.comhttps://bsky.app/profile/natcardiovascres.nature.com/post/3migqms2nxc24❤️Our March issue is out❤️Read about an AI model using echocardiography images improves cardiac diagnosis, LVAD unloading alleviates cellular senescence, inhibition of a hematopoietic death regulator shows cardioprotection, and more. https://www.nature.com/natcardiovascres/volumes/5/issues/301 Apr 2026 12:58 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3migqms2nxc24https://bsky.app/profile/natcardiovascres.nature.com/post/3mfu3x2tv522r❤️Our February issue is out❤️Read about self-powered stent for real-time monitoring, cardiomyocyte regeneration through glucocorticoid receptor antagonism, immunometabolic targeting for type 2 diabetic cardiomyopathy, and more. https://www.nature.com/natcardiovascres/volumes/5/issues/227 Feb 2026 16:10 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3mfu3x2tv522rhttps://bsky.app/profile/natcardiovascres.nature.com/post/3mfttkyoafk2zResearch | Lazarevic et al. reveal a shared loss of a TBX5-dependent atrial gene network in cardiomyocytes and a disease-specific network gain in activated fibroblasts across atrial fibrillation and heart failure models. https://www.nature.com/articles/s44161-025-00775-227 Feb 2026 13:40 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3mfttkyoafk2zhttps://bsky.app/profile/natcardiovascres.nature.com/post/3mfoflzqaac2jResearch|Chen et al. developed a self-powered smart magnetoelastic stent for real-time hemodynamic monitoring and stenosis detection. https://www.nature.com/articles/s44161-025-00773-425 Feb 2026 09:47 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3mfoflzqaac2jhttps://bsky.app/profile/natcardiovascres.nature.com/post/3me7ftzid5k25Research | Da Pra et al. show physiological glucocorticoids suppress growth-factor-induced cardiomyocyte regeneration by inhibiting ERK signaling and propose glucocorticoid receptor antagonism as a strategy to enhance their regenerative effects. https://www.nature.com/articles/s44161-026-00776-9 rdcu.be/e2Fa906 Feb 2026 17:16 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3me7ftzid5k25https://bsky.app/profile/natcardiovascres.nature.com/post/3mcx4322h622s21/01/2026 ❤️Our January issue is out❤️Read about pathogenic mechanism of mutated ribosomal protein PRL3L, identification of cardiac progenitor lineage linked to congenital heart disease, multimodal vision graph for drug repurposing, and more. https://www.nature.com/natcardiovascres/volumes/5/issues/121 Jan 2026 16:35 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3mcx4322h622shttps://bsky.app/profile/natcardiovascres.nature.com/post/3mcrdfd76hs2oResearch | Kathiriya et al identify a cardiac Tbx5+/Mef2cAHF+progenitor lineage that bisects the intraventricular septum during the development and show that alterations in this lineage lead to congenital heart disease. https://www.nature.com/articles/s44161-025-00755-6 rdcu.be/eZGiu19 Jan 2026 09:30 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3mcrdfd76hs2ohttps://bsky.app/profile/natcardiovascres.nature.com/post/3madwirig2s25Big thanks to the Science Ministry of Serbia and our speakers, Drs. Knoblich, Guilliatt, Stewart, & Turco, and Profs. Radisic, Hedtrich, Clevers, Vunjak-Novakovic, Trayanova, Lütolf, Heilshorn, Dvir, Cho & Singh for the great event! https://www.youtube.com/watch?v=4wmna0hv8hY19 Dec 2025 14:44 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3madwirig2s25https://bsky.app/profile/natcardiovascres.nature.com/post/3ma756sezic2m❤️Our December issue is out❤️Read about a method to measure mitochondrial membrane potential in intact hearts, gene therapy for myocardial infarction, genetic association between thromboembolism and long COVID, and more. https://www.nature.com/natcardiovascres/volumes/4/issues/1217 Dec 2025 17:00 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3ma756sezic2mhttps://bsky.app/profile/natcardiovascres.nature.com/post/3m5vrhlqx7s2pResearch | Neo et al. map blood emergence from three hemogenic endothelial (HE) populations biased toward distinct blood fates. HE primed for stem progenitors shows elevated chromatin and RNA splicing gene expression and greater isoform diversity. https://doi.org/10.1038/s44161-025-00740-z rdcu.be/eQxPN18 Nov 2025 12:46 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m5vrhlqx7s2phttps://bsky.app/profile/natcardiovascres.nature.com/post/3m5jcpotdxs2k❤️Our November issue is out❤️Read about an imaging method that combines cardiac electrophysiology with 3D structural heart reconstruction, a targeted glycophagy ATG8 therapy reversing diabetic heart disease, and more. https://www.nature.com/natcardiovascres/volumes/4/issues/1113 Nov 2025 13:50 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m5jcpotdxs2khttps://bsky.app/profile/natcardiovascres.nature.com/post/3m5gtzxobhk27Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis. https://doi.org/10.1038/s44161-025-00739-6 rdcu.be/ePzs612 Nov 2025 14:22 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m5gtzxobhk27https://bsky.app/profile/natcardiovascres.nature.com/post/3m5ehqr7irk2tResearch | Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their beneficial effects. https://doi.org/10.1038/s44161-025-00732-z rdcu.be/ePoLS11 Nov 2025 15:37 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m5ehqr7irk2thttps://bsky.app/profile/natcardiovascres.nature.com/post/3m4xvc4ouek2eResearch | Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promoting fibrous plaques. https://doi.org/10.1038/s44161-025-00737-8 rdcu.be/eOBP006 Nov 2025 15:35 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m4xvc4ouek2ehttps://bsky.app/profile/natcardiovascres.nature.com/post/3m4v5xctev22nResearch | Lin, Geng et al. identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in cell therapy. https://doi.org/10.1038/s44161-025-00716-z rdcu.be/eOoxB05 Nov 2025 13:32 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m4v5xctev22nhttps://bsky.app/profile/natcardiovascres.nature.com/post/3m4ss5oxrms2yResearch | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target. https://doi.org/10.1038/s44161-025-00727-w rdcu.be/eOeTA04 Nov 2025 14:55 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m4ss5oxrms2yhttps://bsky.app/profile/natcardiovascres.nature.com/post/3m4ima2cjs227Research | Yamazoe et al. show that B-cell derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach. https://doi.org/10.1038/s44161-025-00724-z rdcu.be/eNFJV31 Oct 2025 13:43 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m4ima2cjs227https://bsky.app/profile/natcardiovascres.nature.com/post/3m3pi5n64zc2lResearch | Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD1, as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and potential cellular targets. https://doi.org/10.1038/s44161-025-00713-2 rdcu.be/eL2nN21 Oct 2025 13:53 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m3pi5n64zc2lhttps://bsky.app/profile/natcardiovascres.nature.com/post/3m3ahysnnvc2x❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.15 Oct 2025 14:41 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m3ahysnnvc2xhttps://bsky.app/profile/natcardiovascres.nature.com/post/3m35xotlcek2fResearch | Barbera et al. identify and map genetic variants that alter the characteristics of vascular smooth muscle cells and contribute to the risk of coronary artery disease. https://doi.org/10.1038/s44161-025-00714-1 rdcu.be/eKY2S14 Oct 2025 14:43 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m35xotlcek2fhttps://bsky.app/profile/natcardiovascres.nature.com/post/3m33kfc6hec2vResearch | Giardini et al. present an imaging method that combines measurements of cardiac electrophysiology with high-resolution 3D structural reconstructions and detects electrical coupling between cardiomyocytes and non-myocytes in murine hearts. https://doi.org/10.1038/s44161-025-00728-9 rdcu.be/eKNZT13 Oct 2025 15:40 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m33kfc6hec2vhttps://bsky.app/profile/natcardiovascres.nature.com/post/3m2tsswa5bs2tResearch | Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium. https://doi.org/10.1038/s44161-025-00717-y rdcu.be/eKnDf10 Oct 2025 13:50 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m2tsswa5bs2thttps://bsky.app/profile/natcardiovascres.nature.com/post/3m2rhlvjfl22oResearch | Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodelling, and its inhibition blocks collagen turnover and improves heart function. https://doi.org/10.1038/s44161-025-00725-y rdcu.be/eKcfF09 Oct 2025 15:23 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m2rhlvjfl22ohttps://bsky.app/profile/natcardiovascres.nature.com/post/3m2oy6wfshs24Research | Lekkos et al. show that a metabolic switch towards oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish. https://doi.org/10.1038/s44161-025-00718-x rdcu.be/eJ3sB08 Oct 2025 15:42 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m2oy6wfshs24https://bsky.app/profile/natcardiovascres.nature.com/post/3m2mfsttdkk2oResearch | Deficiency of GAPARAPL1 impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and in human organoids of type 2 diabetes. @DelbridgeLab https://doi.org/10.1038/s44161-025-00726-x rdcu.be/eJSl707 Oct 2025 15:08 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3m2mfsttdkk2ohttps://bsky.app/profile/natcardiovascres.nature.com/post/3lzivnlowrc2j❤️Our September issue is out❤️Discover how primary cilia regulate valve development, a human ocular outflow on-chip, regional and sex-specific transcriptional programs in the aorta and more! https://www.nature.com/natcardiovascres/volumes/4/issues/923 Sep 2025 12:16 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3lzivnlowrc2jhttps://bsky.app/profile/natcardiovascres.nature.com/post/3lxk3dshups2sOur chief editor, Vesna Todorovic, and associate editor Andrea Tavosanis are attending the #ESCCongress in Madrid! Get in touch if you would like to learn more about the journal or discuss your work29 Aug 2025 12:40 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3lxk3dshups2shttps://bsky.app/profile/natcardiovascres.nature.com/post/3lwrggwryic2vResearch | Watanabe et al. show that cytopathic hypoxia, through the upregulation of COX2 and secretory PLA2, stabilises HIF-1a, contributing to impaired mitochondrial respiration and reduced cardiac contraction in septic cardiomyopathy. https://doi.org/10.1038/s44161-025-00687-119 Aug 2025 17:22 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3lwrggwryic2vhttps://bsky.app/profile/natcardiovascres.nature.com/post/3lwcbt2aowc23❤️Our August issue is out❤️Discover how premenstrual disorders increase cardiovascular risk, a new diagnostic deep learning model for hypertrophic cardiomyopathy, the relationship between membrane cholesterol accessibility and vascular leakage, and more! https://www.nature.com/natcardiovascres/volumes/4/issues/813 Aug 2025 16:49 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3lwcbt2aowc23https://bsky.app/profile/natcardiovascres.nature.com/post/3lw7qzz6hwc2qZheng et al. generate a triple phospho-ablation mouse model to show that RyR2 phosphorylation at canonical sites is dispensable for chronotropy and inotropy, but required for electrical stability during adrenergic stimulation. rdcu.be/eArYg https://doi.org/10.1038/s44161-025-00693-3 https://rdcu.be/eArYg12 Aug 2025 16:44 +0000at://did:plc:os6opuv5ouf5a7hdvnnuvcdd/app.bsky.feed.post/3lw7qzz6hwc2q