Scientist and Professor in Developmental Epigenetics. Lunenfeld-Tanenbaum Research Institute Dpt Molecular Genetics, University of Toronto, Canada Lab: mrsantoslab.org Coimbra, Portugal -> Cambridge, MA, USA -> S. Francisco, CA, USA -> Toronto, ON, Canadahttps://bsky.app/profile/mrsantos.bsky.socialhttps://bsky.app/profile/mrsantos.bsky.social/post/3mwljobnbnk2xWe are recruiting at the Lunenfeld-Tanenbaum Research Institute (LTRI) and the University of Toronto! In the areas of Reproduction, Pregnancy and Developmental Biology, at Assistant or Associate Professor level. Deadline: Nov 29, 2026 Find more and apply👇: 🔗 apply.interfolio.com/19232428 Sep 2026 14:30 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mwljobnbnk2xhttps://bsky.app/profile/mrsantos.bsky.social/post/3mwe2tuzg5s2bOur PhD student Bryn Martin received the Dr. Louis Siminovitch Catalyst Award from the Dep. of Molecular Genetics at U. Toronto! For excellence in research and mentoring. Note: Louis Siminovitch was a founder of both the Department and the LTRI. Congratulations, Bryn! @sinaihealth.bsky.social25 Sep 2026 15:16 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mwe2tuzg5s2bhttps://bsky.app/profile/mrsantos.bsky.social/post/3muzbkxhdbc2aDiscussed @mrsantos.bsky.social Lit Review: Molecular mediators of cold adaptation in mammalian cells. https://www.nature.com/articles/s42003-025-08838-708 Sep 2026 14:52 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3muzbkxhdbc2ahttps://bsky.app/profile/mrsantos.bsky.social/post/3mufkbux4p22xDiscussed @mrsantos.bsky.social Lit Review: Human haematopoietic stem cells remember inflammatory stress. https://www.nature.com/articles/s41586-026-10522-731 Aug 2026 18:35 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mufkbux4p22xhttps://bsky.app/profile/mrsantos.bsky.social/post/3mtbzpsbo622zCongratulations Giacomo Furlan + Evelyne Collignon for the paper out now in Dec Cell! Mouse embryos don't go to sleep unless told to do so by Nodal/Smad2. Thank you, Liz Robertson! @cp-devcell.bsky.social @sinaihealth.bsky.social 2month full-text access here: https://www.sciencedirect.com/science/article/pii/S1534580726002753?dgcid=author17 Aug 2026 15:35 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mtbzpsbo622zhttps://bsky.app/profile/mrsantos.bsky.social/post/3mrnolb3tek2oLab artists go the Art Gallery of Ontario! - Jul 202627 Jul 2026 19:57 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mrnolb3tek2ohttps://bsky.app/profile/mrsantos.bsky.social/post/3mq2sgys5mc2aCongratulations to our Lab PhD student on successfully passing the PhD defense on June 22, 2026! Your dedication, perseverance, and commitment have culminated in this remarkable achievement. Wishing you continued success in the next chapter of your career. Congratulations, Dr.Andrew!07 Jul 2026 14:21 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mq2sgys5mc2ahttps://bsky.app/profile/mrsantos.bsky.social/post/3moildud7ts22Discussed @mrsantos.bsky.social lit review: Germline epigenome editing identifies H3K9me3 as a mediator of intergenerational DNA methylation recovery in mice. https://www.nature.com/articles/s41467-025-67488-917 Jun 2026 15:00 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3moildud7ts22https://bsky.app/profile/mrsantos.bsky.social/post/3mods6rqqgc2mLove the smell of "accepted in principle" in the (Monday) morning...15 Jun 2026 17:20 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mods6rqqgc2mhttps://bsky.app/profile/mrsantos.bsky.social/post/3mnxhtwo5wk22Discussed @mrsantos.bsky.social lit review: Nascent transcriptome of embryonic genome activation reveals a regulatory axis linking transcriptional priming to early lineage specification in mouse embryos. https://academic.oup.com/nar/article/54/5/gkag173/850055910 Jun 2026 19:43 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mnxhtwo5wk22https://bsky.app/profile/mrsantos.bsky.social/post/3mleh44yanc2hIn our latest anti-bias lab meeting, we discussed the global impacts for societies and scientific research of the blockade of the Strait of Hormuz arising from the war of US and Israel with Iran.08 May 2026 19:18 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mleh44yanc2hhttps://bsky.app/profile/mrsantos.bsky.social/post/3mijmtcv5yc2sDiscussed @mrsantos.bsky.social lit review: Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters. https://onlinelibrary.wiley.com/doi/10.1002/anie.20251661302 Apr 2026 16:28 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mijmtcv5yc2shttps://bsky.app/profile/mrsantos.bsky.social/post/3mhvmnuglr22bDiscussed @mrsantos.bsky.social lit review: Heritable changes in chromatin contacts associated with transgenerational susceptibility to diet induced insulin dysregulation and obesity. rdcu.be/e910l https://rdcu.be/e910l25 Mar 2026 17:32 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mhvmnuglr22bhttps://bsky.app/profile/mrsantos.bsky.social/post/3mht36pr2t226Great work by Brandon Cho, our fantastic student-turned-postdoc, out now in Oncogene. Great collaboration w Linda Penn (Toronto). We put the chromatin remodeller CHD1 in an "epistasis battle" with overexpression of THE oncogene MYC in a breast cancer model. 1/2 https://www.nature.com/articles/s41388-026-03709-924 Mar 2026 17:14 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mht36pr2t226https://bsky.app/profile/mrsantos.bsky.social/post/3mgvdvanpkc2sReally proud of our stellar lab manager, Kirti Mittal! 1st author in a paper out in @genesdev.bsky.social. From chromatin-bound RNA to functional studies in human ESCs, she discovered a new role for alpha-satellite repeats in nuclear compartmentalization. Congrats! pubmed.ncbi.nlm.nih.gov/41730687/12 Mar 2026 21:30 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mgvdvanpkc2shttps://bsky.app/profile/mrsantos.bsky.social/post/3mfp436jkuk2zDiscussed @mrsantosny.bsky.social lit review: Stress controls heterochromatin inheritance via histone H3 ubiquitylation. https://www.nature.com/articles/s41586-025-09899-825 Feb 2026 16:29 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mfp436jkuk2zhttps://bsky.app/profile/mrsantos.bsky.social/post/3mf5xjfqitk2wDiscussed @mrsantos.bsky.social lit review: Cell-type-specific RNA polymerase II activity maps in intact tissues provide a gateway to mammalian gene regulatory mechanisms in vivo. https://www.cell.com/developmental-cell/fulltext/S1534-5807(25)00602-118 Feb 2026 20:52 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3mf5xjfqitk2whttps://bsky.app/profile/mrsantos.bsky.social/post/3m6zjuu5cts2zDiscussed @mrsantos.bsky.social lit review: Stabilizing a mammalian RNA thermometer confers neuroprotection in subarachnoid hemorrhage. https://www.nature.com/articles/s41467-025-63911-302 Dec 2025 18:06 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3m6zjuu5cts2zhttps://bsky.app/profile/mrsantos.bsky.social/post/3m6kezycf4s2tDiscussed @mrsantos.bsky.social lit review: Analog epigenetic memory revealed by targeted chromatin editing. https://www.sciencedirect.com/science/article/pii/S2666979X2500241126 Nov 2025 17:30 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3m6kezycf4s2thttps://bsky.app/profile/mrsantos.bsky.social/post/3m5cdvmyjcs2xTrick or Treat! 👻🎃10 Nov 2025 19:23 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3m5cdvmyjcs2xhttps://bsky.app/profile/mrsantos.bsky.social/post/3m3rz5nmfd22aDiscussed @mrsantos.bsky.social lit review: Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells. https://www.biorxiv.org/content/10.1101/2024.09.07.611779v1.full22 Oct 2025 14:03 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3m3rz5nmfd22ahttps://bsky.app/profile/mrsantos.bsky.social/post/3m3og7zftds2d21 Oct 2025 03:46 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3m3og7zftds2dhttps://bsky.app/profile/mrsantos.bsky.social/post/3m3agyn4pmc27Discussed @mrsantos.bsky.social lit review: Preventing CpG hypermethylation in oocytes safeguards mouse development. https://www.cell.com/developmental-cell/fulltext/S1534-5807(25)00505-215 Oct 2025 14:23 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3m3agyn4pmc27https://bsky.app/profile/mrsantos.bsky.social/post/3m2rxhutunk2b(1/4) New Pre-print! 🌟 Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.09 Oct 2025 20:08 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3m2rxhutunk2bhttps://bsky.app/profile/mrsantos.bsky.social/post/3m2mvxhwwek27John Gurdon was a true giant: - founder of cell reprogramming; - founder of molecular embryology; - unabashed advocate for basic research; - advisor to numerous successful trainees/PIs; - gentle human that touched so many. In dark times with science under attack, let his vision be a guiding light. [contains quote post or other embedded content]07 Oct 2025 19:57 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3m2mvxhwwek27https://bsky.app/profile/mrsantos.bsky.social/post/3lzlswfanoc2u🚨 JOB ALERT 🚨 We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. Apply now or repost! [contains quote post or other embedded content]24 Sep 2025 16:05 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3lzlswfanoc2uhttps://bsky.app/profile/mrsantos.bsky.social/post/3lyg7cuzxj22pThank you for this honor and the continued trust in our group's research! We hope that our work will honor the memory and legacy of Anne and Max Tanenbaum. It is truly a privilege to be part of the amazing communities of @uoftmedicine.bsky.social and @sinaihealth.bsky.social. [contains quote post or other embedded content]09 Sep 2025 17:06 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3lyg7cuzxj22phttps://bsky.app/profile/mrsantos.bsky.social/post/3lxztxwitqc2g(1/4) New preprint from the lab! The MYC transcription factor is a potent cancer driver when its expression is dysregulated, but efforts to target MYC directly have not been fruitful. We identify CHD1 as a synthetic lethal vulnerability in MYC-driven breast cancer. https://www.biorxiv.org/content/10.1101/2025.08.14.670376v104 Sep 2025 19:11 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3lxztxwitqc2ghttps://bsky.app/profile/mrsantos.bsky.social/post/3lw7k66cvok22‪Discussed @mrsantos.bsky.social lit review: A single-cell time-lapse of mouse prenatal development from gastrula to birth. https://www.nature.com/articles/s41586-024-07069-w12 Aug 2025 14:41 +0000at://did:plc:qf2ffotjzgc75ak2wuhrcix4/app.bsky.feed.post/3lw7k66cvok22