Diverse Human References Drive Genomic Discoveries for Everyonehttps://bsky.app/profile/humanpangenome.bsky.socialhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mwtwrfx3u22fHPRC developed its consent document through a 3-year collaboration among scientific, ethical, legal, and community experts. It prioritizes transparency and informed participation, with language designed to be clear and accessible. Read the full document: humanpangenome.org/consent/ https://humanpangenome.org/consent/01 Oct 2026 22:46 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mwtwrfx3u22fhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mwboqquyrk2tShredtools is making it easier to explore regions across a pangenome by quickly finding matching genomic regions across hundreds of genomes. The tool can identify a gene region across 476 human genomes in approximately half a second.  Read more: https://www.biorxiv.org/content/10.64898/2026.07.03.736354v124 Sep 2026 16:34 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mwboqquyrk2thttps://bsky.app/profile/humanpangenome.bsky.social/post/3mv4bb6c6fs2pThe Resource Improvement and Maintenance Working Group evaluates the pangenome’s quality, develops QC approaches, and helps define stable reference releases. Explore this and other HPRC working groups: https://humanpangenome.org/working-groups/09 Sep 2026 19:24 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mv4bb6c6fs2phttps://bsky.app/profile/humanpangenome.bsky.social/post/3muiddtofrc2vThis study shows how CRISPRa can recreate transcriptional states seen in cell atlases, helping identify their regulators and functions.  The approach reveals factors linked to universal and disease-associated states, advancing functional and therapeutic research.  https://www.nature.com/articles/s41588-025-02284-101 Sep 2026 21:08 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3muiddtofrc2vhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mu5y7njhik23A varied, high-quality human reference is key to understanding genetic variation.  HPRC is expanding sampling beyond 1000 Genomes to build a richer, more complete reference that can advance disease research. Learn more: www.humanpangenome.org/samples https://www.humanpangenome.org/samples28 Aug 2026 18:23 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mu5y7njhik23https://bsky.app/profile/humanpangenome.bsky.social/post/3mtysf5q5r22zPangenome coordinates can be complex... Shredtools offers a new approach using exact matches to query pangenome data efficiently. Its tools can extract syntenic regions across hundreds of genomes, making pangenome-scale exploration more accessible. pubmed.ncbi.nlm.nih.gov/42465356/ https://pubmed.ncbi.nlm.nih.gov/42465356/26 Aug 2026 16:55 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mtysf5q5r22zhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mtjzkjzp4c2kExplore HPRC data! The HPRC Data Explorer provides access to sequencing data from across the consortium, supporting research into human genetic variation and the development of a more complete pangenome reference. Explore the data: https://data.humanpangenome.org/raw-sequencing-data20 Aug 2026 19:53 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mtjzkjzp4c2khttps://bsky.app/profile/humanpangenome.bsky.social/post/3msjbysgvuc23Explore the HPRC YouTube channel for educational videos, Q&As, and a closer look at the people and work behind the Human Pangenome Reference Consortium. ▶️ Watch on YouTube⁠: https://www.youtube.com/@HumanPangenome07 Aug 2026 19:27 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3msjbysgvuc23https://bsky.app/profile/humanpangenome.bsky.social/post/3msgby55aic2jTransparency is central to HPRC. Our consent process was developed through years of collaboration with scientists, ethicists, legal experts, and community representatives to support informed participation. Learn more: humanpangenome.org/consent/ https://humanpangenome.org/consent/06 Aug 2026 14:48 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3msgby55aic2jhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mrvbd6psxs2tCatch the HPRC panel discussion from the 7th ELSI Congress: Building an Open Genomic Reference Resource - Consent and Participant Perspectives in the Human Pangenome Reference Consortium. Watch here: https://vimeo.com/1206495017?fl=pl&fe=sh30 Jul 2026 20:21 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mrvbd6psxs2thttps://bsky.app/profile/humanpangenome.bsky.social/post/3mrgbchkrmc2aExplore the HPRC Year 2 pangenome graph with Graphoscope. Search a gene or genomic region to visualize the pangenome graph at that locus with no pangenome data or specialized setup required. Try it here: https://marianattestad.github.io/graphoscope/?ref=grch38&locus=SMN124 Jul 2026 21:11 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mrgbchkrmc2ahttps://bsky.app/profile/humanpangenome.bsky.social/post/3mrb5fvl4522dWe need more than one human reference genome. Since 2019, HPRC has been working to move beyond the limitations of a single reference by building resources that better capture human genetic variation, bringing us closer to a more complete picture of the human genome.22 Jul 2026 20:18 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mrb5fvl4522dhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mqmvzragws2wA new approach to local ancestry inference moves beyond discrete ancestry labels, representing genetic ancestry as a continuous “point cloud” of genomic segments. By capturing ancestry across space & time, the framework offers new insights into human genetic history. https://www.biorxiv.org/content/10.64898/2026.03.23.713813v114 Jul 2026 19:13 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mqmvzragws2whttps://bsky.app/profile/humanpangenome.bsky.social/post/3mqah64xmts2fFrom the first draft to a global resource, HPRC’s release timeline shows how the human pangenome continues to grow in scale, accuracy, and representation. Explore the milestones shaping the future of genomics: www.humanpangenome.org/release-timeline/09 Jul 2026 20:15 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mqah64xmts2fhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mplv4c4yvc2qToday, July 1, is the last day to register and submit an abstract for the T2T 2026 conference.  Sept. 3–4 in Santa Cruz, CA, join the telomere-to-telomere and pangenomics community!  Learn more: https://sites.google.com/ucsc.edu/t2t-f2f01 Jul 2026 15:58 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mplv4c4yvc2qhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mp7nnfwrzk2pJuly 1 is the deadline to register and submit abstracts for the T2T Face-to-Face 2026 conference! Join the community Sept. 3–4 in Santa Cruz, CA, for two days of science, collaboration, and discussion around telomere-to-telomere genomics. Learn more: https://sites.google.com/ucsc.edu/t2t-f2f26 Jun 2026 19:13 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mp7nnfwrzk2phttps://bsky.app/profile/humanpangenome.bsky.social/post/3mp4yqjime22yWhat is a reference genome? 🧬 In the context of HPRC, a reference genome is a low-error genome and associated annotation coordinate system that serves as the backbone for genome alignment. Explore more HPRC definitions: humanpangenome.org/definitions/25 Jun 2026 17:53 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mp4yqjime22yhttps://bsky.app/profile/humanpangenome.bsky.social/post/3moo54n2ezc2tResearchers resolved 135 chromosome 22q11.2 haplotypes, revealing structural variation that influences susceptibility to 22q11.2 deletion syndrome and may help explain its reduced prevalence among individuals of African ancestry. Read more: https://www.nature.com/articles/s41467-026-71905-y19 Jun 2026 20:02 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3moo54n2ezc2thttps://bsky.app/profile/humanpangenome.bsky.social/post/3modxgp7cfc2c📢 Reminder: Registration and abstract submissions for the T2T Face-to-Face 2026 conference close July 1! Join the telomere-to-telomere and pangenomics community Sept. 3–4 at UC Santa Cruz. Abstracts welcome for both talks and posters. Learn more: https://sites.google.com/ucsc.edu/t2t-f2f15 Jun 2026 18:53 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3modxgp7cfc2chttps://bsky.app/profile/humanpangenome.bsky.social/post/3mnsg2n6fok2tWhat new technologies are shaping the future of genomics? Erik Garrison, PhD, discusses advances in genome assembly, long-read sequencing, and pangenome graphs, and how they’re helping reveal previously hidden regions of the human genome. ▶️ youtu.be/BmbcGyrmPu4 https://youtu.be/BmbcGyrmPu408 Jun 2026 19:27 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mnsg2n6fok2thttps://bsky.app/profile/humanpangenome.bsky.social/post/3mnfuwob6522lWhat is a reference genome? 🧬 In the context of HPRC, a reference genome is a low-error genome and associated annotation coordinate system that serves as the backbone for genome alignment. Explore more HPRC definitions: humanpangenome.org/definitions/ https://humanpangenome.org/definitions/03 Jun 2026 19:49 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mnfuwob6522lhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mmwixf63ns2aResearchers generated an atlas of telomere-spanning molecules across 212 diploid human genomes, uncovering heritable telomere variant repeat “codes” and insights into telomerase-independent telomere extension mechanisms. Uncover the science behind it: https://www.biorxiv.org/content/10.64898/2026.05.01.722200v128 May 2026 17:05 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mmwixf63ns2ahttps://bsky.app/profile/humanpangenome.bsky.social/post/3mmrtk365r22vAbstract submissions for the T2T Face-to-Face conference are open through June 15th!  Join the community Sept. 3–4 in Santa Cruz, CA, for two days of discussion and collaboration around telomere-to-telomere genomics and pangenomics. Learn more: https://sites.google.com/ucsc.edu/t2t-f2f26 May 2026 20:31 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mmrtk365r22vhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mm7zhhklbs2nA more complete understanding of human genetics starts with broader representation.  HPRC samples help capture global human genetic variation to build richer reference resources and improve disease research and genomic medicine.  Learn more: humanpangenome.org/samples/ https://humanpangenome.org/samples/19 May 2026 18:29 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mm7zhhklbs2nhttps://bsky.app/profile/humanpangenome.bsky.social/post/3mltidma5ks2jRecent research explores the evolution and regulation of the human-specific NOTCH2NL gene family using near-complete long-read assemblies from humans and apes. Uncover the science behind it: https://www.cell.com/cell-genomics/fulltext/S2666-979X%2826%2900056-X14 May 2026 18:50 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mltidma5ks2jhttps://bsky.app/profile/humanpangenome.bsky.social/post/3ml7eectzc22gHow can collaboration shape a scientific career? Andrea Guarracino, PhD, shares how HPRC transformed his path, from developing genome tools to making discoveries and teaching globally. ▶️ Watch the Q&A: youtu.be/yxmnq2rUaEk https://youtu.be/yxmnq2rUaEk06 May 2026 18:46 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3ml7eectzc22ghttps://bsky.app/profile/humanpangenome.bsky.social/post/3mkq4dradcs2tA recent preprint introduces TumorLens, a long-read framework for unified cancer profiling, detecting genetic and epigenetic alterations in a single assay, from SNVs to methylation. Uncover the science behind it: https://www.medrxiv.org/content/10.64898/2026.03.18.26348569v130 Apr 2026 17:12 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mkq4dradcs2thttps://bsky.app/profile/humanpangenome.bsky.social/post/3mkbg26kvcs24Scenes from the HUGO workshop in Athens, Greece 🇬🇷 HPRC collaboration in action, advancing pangenomics both stateside and abroad.24 Apr 2026 20:56 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mkbg26kvcs24https://bsky.app/profile/humanpangenome.bsky.social/post/3mk43r7kmvs2gMemPanG26: join a computational pangenomics course, conference, and biohackathon exploring cutting-edge methods, AI, and genomic research. Talk proposals are welcome from varied perspectives across species and disciplines. Learn more & submit: pangenome.github.io/MemPanG26/22 Apr 2026 18:09 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mk43r7kmvs2ghttps://bsky.app/profile/humanpangenome.bsky.social/post/3mjff2aro3k2fNew tutorial 🛠️ Explore how to use VDJcraft, an integrated pipeline for analyzing V(D)J recombination from long-read transcriptome data. Kaili Hu walks through the workflow and real-world applications. Watch now: youtu.be/Zi8qTPSOAdc https://youtu.be/Zi8qTPSOAdc13 Apr 2026 17:24 +0000at://did:plc:qmvxpm53atfjdt5cs2e5jshf/app.bsky.feed.post/3mjff2aro3k2f