The Molecular Physiology of Aging in Madison, WI. All views that of Dr. Lamming and do not necessarily reflect that of my employers, funders, or societies. Retweet≠Endorse. http://www.lamminglab.org/https://bsky.app/profile/lamminglab.bsky.socialhttps://bsky.app/profile/lamminglab.bsky.social/post/3mkt4g4cyxc2vTerrific Department of Medicine Research, and congratulations to Dr. Yang Yeh and Bailey Knopf for winning poster awards and Dr. Mariah Calubag for receiving the DOM Outstanding Graduate Student Award!01 May 2026 21:52 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3mkt4g4cyxc2vhttps://bsky.app/profile/lamminglab.bsky.social/post/3mjprp23hx22yThree amazing award winners from the Lamming Lab at the 7th Annual Midwest Aging Consortium Meeting! Congratulations to all the winners and all participants! @baileyknopf.bsky.social Yang Yeh and Amirah Nieves Medina!17 Apr 2026 20:37 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3mjprp23hx22yhttps://bsky.app/profile/lamminglab.bsky.social/post/3mgx46kybnc2sPlease enjoy the latest publication from our lab "Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice" https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.20251522013 Mar 2026 14:17 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3mgx46kybnc2shttps://bsky.app/profile/lamminglab.bsky.social/post/3mdlokx45ic2rHad a fantastic metabolism and aging retreat yesterday with the @judisimcox.bsky.social and @wiscosurgicalmetab.bsky.social labs!29 Jan 2026 20:59 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3mdlokx45ic2rhttps://bsky.app/profile/lamminglab.bsky.social/post/3malo5cjp4k2qWith the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.22 Dec 2025 16:36 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3malo5cjp4k2qhttps://bsky.app/profile/lamminglab.bsky.social/post/3mac35f2i2c2vPleased to annouce the publication of our new collaboration with Spencer Haws and @johndenu.bsky.social "Depletion of individual dietary amino acids induce distinct metabolic and chromatin states"18 Dec 2025 21:02 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3mac35f2i2c2vhttps://bsky.app/profile/lamminglab.bsky.social/post/3m7qhdtrcls2pPleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!11 Dec 2025 20:52 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3m7qhdtrcls2phttps://bsky.app/profile/lamminglab.bsky.social/post/3m2bzsj6tms2lPerhaps the most important paper of the decade with respect to how cells sense amino acid insufficiency, finally laying to rest the idea that GCN2 is activated by uncharged tRNAs! [contains quote post or other embedded content]03 Oct 2025 12:07 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3m2bzsj6tms2lhttps://bsky.app/profile/lamminglab.bsky.social/post/3lynhnmgn222lWe have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! https://www.sciencedirect.com/science/article/pii/S221287782500155312 Sep 2025 14:23 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lynhnmgn222lhttps://bsky.app/profile/lamminglab.bsky.social/post/3ly3ubzdc7k2pOur most recent work by graduate student @mariahcalubag - demonstrating the sex-specific extension of lifespan by valine restriction was presented last week at #ARDD2025 and is now available on bioRxiv! Thanks to Daniela Bakula, @scheibyeknudsenlab.bsky.social, and Alex Zhavoronkov for the invite!05 Sep 2025 14:22 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3ly3ubzdc7k2phttps://bsky.app/profile/lamminglab.bsky.social/post/3lvlwhevy5s2v"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! https://www.nature.com/articles/s41467-025-62416-304 Aug 2025 19:27 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lvlwhevy5s2vhttps://bsky.app/profile/lamminglab.bsky.social/post/3lv47lia2gs23I am pleased to report our new manuscript from graduate student Mariah Calubag and collaborators and colleagues, "Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids" is now available! https://onlinelibrary.wiley.com/doi/10.1111/acel.7017629 Jul 2025 13:28 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lv47lia2gs23https://bsky.app/profile/lamminglab.bsky.social/post/3luxeqir5uc2kPleased to announce the last major project from former graduate student Dr. Babygirija is now available on biorxiv - "Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice" https://www.biorxiv.org/content/10.1101/2025.07.24.663565v127 Jul 2025 15:17 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3luxeqir5uc2khttps://bsky.app/profile/lamminglab.bsky.social/post/3lr6cychlfc2sAnother win for rapamycin: https://www.nature.com/articles/s41598-025-02707-309 Jun 2025 11:54 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lr6cychlfc2shttps://bsky.app/profile/lamminglab.bsky.social/post/3lqfck6fkis2cSad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging. https://www.legacy.com/us/obituaries/bostonglobe/name/thomas-blackwell-obituary?id=5846389230 May 2025 13:09 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lqfck6fkis2chttps://bsky.app/profile/lamminglab.bsky.social/post/3lpcts5ulws2iGlad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" https://www.nature.com/articles/s41467-025-59869-x16 May 2025 20:15 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lpcts5ulws2ihttps://bsky.app/profile/lamminglab.bsky.social/post/3lotzped2b22pHeading to the @americanaging.bsky.social meeting with @mattyousefzadeh.bsky.social and Holly Brown-Borg!10 May 2025 22:50 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lotzped2b22phttps://bsky.app/profile/lamminglab.bsky.social/post/3lot5jjdshk2pIt was an honor yesterday to hood graduate student Reji Babygirija and escort her at commencement. Big thanks to the keynote speaker for our hooding ceremony Dr. Christine Whelan who gave a highly inspiring and impactful address!10 May 2025 14:26 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lot5jjdshk2phttps://bsky.app/profile/lamminglab.bsky.social/post/3lno4gxifm22uCatching up on the week - awesome @AgingMidwest meeting in Rochester, MN! Congrats to @baileyknopf for a terrific talk and winning a travel award, and @iCCup_Spec for winning a poster award!25 Apr 2025 20:58 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lno4gxifm22uhttps://bsky.app/profile/lamminglab.bsky.social/post/3lfx6yzuvdc2qPleased to announce our lab's latest pre-print by graduate student Mariah Calubag "Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids" https://www.biorxiv.org/content/10.1101/2025.01.13.632607v117 Jan 2025 16:17 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lfx6yzuvdc2qhttps://bsky.app/profile/lamminglab.bsky.social/post/3lem5s7ahak2kWith the end of the year upon us, it's time for the 2024 @LammingLab year in review! Some of our accomplishments and successes are described in the thread below.31 Dec 2024 13:30 +0000at://did:plc:rculkcaba5ebmolpmfoudrke/app.bsky.feed.post/3lem5s7ahak2k