Computational biologist at Fred Hutchinson Cancer Center (See my work here: https://dcjones.github.io/). I also post about baking, books, and Seattle politics.https://bsky.app/profile/dcjones.bsky.socialhttps://bsky.app/profile/dcjones.bsky.social/post/3mptxbeecf224Can't ask fable a specific question about a specific data structure in a transcriptomics project because it thinks I'm designing bioweapons 😓04 Jul 2026 20:58 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3mptxbeecf224https://bsky.app/profile/dcjones.bsky.social/post/3mn2bgfu6dk2mI live in the fifa pedestrian zone and I endorse this message. [contains quote post or other embedded content]30 May 2026 05:00 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3mn2bgfu6dk2mhttps://bsky.app/profile/dcjones.bsky.social/post/3mknkdxrfd22cIran war has cost $25 billion ≈ 1 NASA ≈ 2.5 NSFs ≈ 0.5 NIHs ≈ 0.25 SNAPs https://apnews.com/live/iran-war-hegseth-congress-trump-updates-04-29-2026?utm_source=copy&utm_medium=share29 Apr 2026 16:45 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3mknkdxrfd22chttps://bsky.app/profile/dcjones.bsky.social/post/3mep5tycnrs22Seattle housing is so cooked 😩12 Feb 2026 23:36 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3mep5tycnrs22https://bsky.app/profile/dcjones.bsky.social/post/3me52mgqybc2kKatie Wilson bringing back the SuperSonics would be the funniest timeline, so I choose to believe https://www.seattletimes.com/sports/sonics/gov-bob-ferguson-meeting-with-nba-commissioner-adam-silver-on-thursday/05 Feb 2026 18:50 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3me52mgqybc2khttps://bsky.app/profile/dcjones.bsky.social/post/3me4wun27ks2fTurns out you don't actually need a central bank to debase your currency. Such innovation!05 Feb 2026 17:43 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3me4wun27ks2fhttps://bsky.app/profile/dcjones.bsky.social/post/3mago5uw33k2c"We often blame bureaucrats or red tape for the country’s paralysis. But the fault lies less in the rules than in who has the resources to weaponize them." https://open.substack.com/pub/data4democracy/p/how-regulation-by-litigation-strangled https://open.substack.com/pub/data4democracy/p/how-regulation-by-litigation-strangled?utm_source=share&utm_medium=android&shareImageVariant=overlay&r=5lp1s220 Dec 2025 16:53 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3mago5uw33k2chttps://bsky.app/profile/dcjones.bsky.social/post/3maebko63s22lI went all out optimizing proseg this week, and after many rounds of profiling and tinkering, the new release is as much as 1.5-4x faster and reduces memory usage by around 10%. More importantly, I discovered and fixed a subtle bug that reduced segmentation accuracy for large gene panels!19 Dec 2025 18:02 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3maebko63s22lhttps://bsky.app/profile/dcjones.bsky.social/post/3m7nroi22vc2zFeel like pure shit just want her back https://en.wikipedia.org/wiki/Good_Neighbor_policy10 Dec 2025 19:19 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m7nroi22vc2zhttps://bsky.app/profile/dcjones.bsky.social/post/3m7g3c4emlk2lI'm somehow just discovering that there's pretty compelling deep learning framework being built in rust https://burn.dev/books/burn/motivation.html07 Dec 2025 17:50 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m7g3c4emlk2lhttps://bsky.app/profile/dcjones.bsky.social/post/3m746qd7hoc2wI'm never going to be able to afford memory again. Might just pivot all my work towards probabilistic data structures and online stats. https://www.reuters.com/business/micron-exit-crucial-consumer-memory-business-2025-12-03/03 Dec 2025 19:25 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m746qd7hoc2whttps://bsky.app/profile/dcjones.bsky.social/post/3m5tphc6ntk23Lingonberry cruffins. Going full Scandinavia mode lately.17 Nov 2025 17:05 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m5tphc6ntk23https://bsky.app/profile/dcjones.bsky.social/post/3m5oxeet7h22rGot my copy of the inaugural issue of Seattle-centric baking magazine Crumb. It's good! www.readcrumb.co15 Nov 2025 19:43 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m5oxeet7h22rhttps://bsky.app/profile/dcjones.bsky.social/post/3m5fqpilpac2zCosign this. I was frustrated on election night when no seemed to be able to say what exactly the range likely outcomes was. Fortunately @elections.kingcounty.gov provides a lot of historical data. I had fun digging into it with @ronpdavis.bsky.social and learning it's actually fairly predictable! [contains quote post or other embedded content]12 Nov 2025 03:50 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m5fqpilpac2zhttps://bsky.app/profile/dcjones.bsky.social/post/3m5ffmda3fk23Really wasn't a sure thing a few drops ago (it could have followed one of these shallower historical trajectories and missed the mark), but it's certainly nearly a sure thing now.12 Nov 2025 00:32 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m5ffmda3fk23https://bsky.app/profile/dcjones.bsky.social/post/3m5cwhejews2lUpdating my plot on Katie Wilson's latest numbers compared to previous races. Progressive vote share sometimes drops a little in the last few percent, but it's extremely unlikely that it's enough to reverse her lead at this point.11 Nov 2025 00:55 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m5cwhejews2lhttps://bsky.app/profile/dcjones.bsky.social/post/3m5ctjl5fpk2cThey're calling him the Nate Silver of Seattle. (Except I learned stats and epistemology from books, not internet poker, and I haven't cooked my brain with twitter addiction.) [contains quote post or other embedded content]11 Nov 2025 00:03 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m5ctjl5fpk2chttps://bsky.app/profile/dcjones.bsky.social/post/3m5c46bxk422sLast big drop of ballots hits this afternoon, so we'll see if I'm right, but I think Katie Wilson is going to win (by a narrow margin). As shown here, she needs to as well or better in the last 17% of the ballots as she did on Friday's drop. The good news is that this is pretty likely. [contains quote post or other embedded content]10 Nov 2025 17:05 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m5c46bxk422shttps://bsky.app/profile/dcjones.bsky.social/post/3m5cep4tcck24Turns out the ongoing debate about the dangers of increased surveillance in the city was not entirely hypothetical. [contains quote post or other embedded content]10 Nov 2025 19:37 +0000at://did:plc:rdrjro6dbd3orm4wsaxwqbf3/app.bsky.feed.post/3m5cep4tcck24