JAMA Oncology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications. 🌐 JAMAOncology.comhttps://bsky.app/profile/jamaoncology.comhttps://bsky.app/profile/jamaoncology.com/post/3mt2cydsjss2zA 79-year-old woman with high-risk myelodysplastic syndrome treated with 5-azacitidine presented with painful ulcers on the tongue and right lower extremity. What is your diagnosis? ja.ma/4wVRi9f14 Aug 2026 14:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mt2cydsjss2zhttps://bsky.app/profile/jamaoncology.com/post/3msxz7yzfcc2fAmong patients with early #TripleNegativeBreastCancer, tissue-free #ctDNA detection during molecular residual disease surveillance was strongly prognostic for recurrence and supported testing when tumor tissue was unavailable. ja.ma/3S5A0Hu13 Aug 2026 16:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3msxz7yzfcc2fhttps://bsky.app/profile/jamaoncology.com/post/3msxxkdvp5i2qAmong men with #ProstateCancer starting concurrent androgen deprivation therapy and an androgen receptor pathway inhibitor, #MetabolicSyndrome and related abnormalities were frequently documented early, with hypertension the most common outcome. ja.ma/3TW65Cf13 Aug 2026 15:30 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3msxxkdvp5i2qhttps://bsky.app/profile/jamaoncology.com/post/3msvc2iyxiq2yAmong patients with metastatic #BreastCancer, alert-based digital patient-reported outcome monitoring was associated with lower fatigue at 6 months vs usual care, with improvement exceeding the minimal clinically important difference. ja.ma/4xzjmPF12 Aug 2026 14:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3msvc2iyxiq2yhttps://bsky.app/profile/jamaoncology.com/post/3msuxymwoul24Adding consolidative thoracic radiotherapy to atezolizumab maintenance for extensive-stage small cell lung cancer led to more severe toxic effects, mainly infections, without survival benefit compared to atezolizumab alone. ja.ma/3UsSpyJ12 Aug 2026 11:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3msuxymwoul24https://bsky.app/profile/jamaoncology.com/post/3msq2g2ozzb2tAdding consolidative thoracic radiotherapy to atezolizumab maintenance for extensive-stage small cell lung cancer led to more severe toxic effects, mainly infections, without survival benefit compared to atezolizumab alone. ja.ma/4wjlR7I10 Aug 2026 12:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3msq2g2ozzb2thttps://bsky.app/profile/jamaoncology.com/post/3msnxec2trz2yIn patients with #ProstateCancer receiving #AdaptiveTherapy, mathematical biomarkers from first-cycle prostate-specific antigen (#PSA) dynamics predicted time to progression and overall survival better than standard PSA metrics. ja.ma/4wbDsyf09 Aug 2026 16:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3msnxec2trz2yhttps://bsky.app/profile/jamaoncology.com/post/3msntyyul362kAmong patients with metastatic #BreastCancer, alert-based digital patient-reported outcome monitoring was associated with lower fatigue at 6 months vs usual care, with improvement exceeding the minimal clinically important difference. ja.ma/4hmHGPX09 Aug 2026 15:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3msntyyul362khttps://bsky.app/profile/jamaoncology.com/post/3msldk4awym2tAmong patients with metastatic #BreastCancer, alert-based digital patient-reported outcome monitoring was associated with lower fatigue at 6 months vs usual care, with improvement exceeding the minimal clinically important difference. ja.ma/4bxDWHQ08 Aug 2026 15:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3msldk4awym2thttps://bsky.app/profile/jamaoncology.com/post/3msla6syfwi26In patients with #ProstateCancer receiving #AdaptiveTherapy, mathematical biomarkers from first-cycle prostate-specific antigen (#PSA) dynamics predicted time to progression and overall survival better than standard PSA metrics. ja.ma/4cahe8J08 Aug 2026 14:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3msla6syfwi26https://bsky.app/profile/jamaoncology.com/post/3mrnj37oeml2sAdding consolidative thoracic radiotherapy to atezolizumab maintenance for extensive-stage small cell lung cancer led to more severe toxic effects, mainly infections, without survival benefit compared to atezolizumab alone. ja.ma/4wq74ZI27 Jul 2026 18:19 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mrnj37oeml2shttps://bsky.app/profile/jamaoncology.com/post/3mrn5xvzbcn2d💬 Viewpoint: In #Oncology, payment incentives may shape the context of care recommendations, and directional disclosure of those incentives deserves consideration as part of informed consent. ja.ma/4x8ET1B27 Jul 2026 15:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mrn5xvzbcn2dhttps://bsky.app/profile/jamaoncology.com/post/3mrn45yssll2qIn a phase 1 trial of ultralow-dose IL-10–expressing CD19 CAR T cells for diffuse large B-cell lymphoma, 92% of adults had objective responses and most toxicities were grade 1-2, supporting further evaluation of cytokine-engineered CAR T strategies. ja.ma/4fk0oGA27 Jul 2026 14:28 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mrn45yssll2qhttps://bsky.app/profile/jamaoncology.com/post/3mrhwctselu24Among adults with #obesity, use of #GLP-1 receptor agonists was associated with reduced risk of endometrial, ovarian, and meningioma cancers and a slight increase in kidney #cancer risk. 📖 Read the full article for more details: ja.ma/4hdC2Q425 Jul 2026 13:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mrhwctselu24https://bsky.app/profile/jamaoncology.com/post/3mqubo2nvb42qIn metastatic breast cancer trials, progression-free survival by blinded central review and investigator assessment was similar, supporting use of either method for endpoint evaluation. ja.ma/4w2Lcn417 Jul 2026 17:30 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mqubo2nvb42qhttps://bsky.app/profile/jamaoncology.com/post/3mqet4zhlmm27Adding consolidative thoracic radiotherapy to atezolizumab maintenance for extensive-stage small cell lung cancer led to more severe toxic effects, mainly infections, without survival benefit compared to atezolizumab alone. ja.ma/4vjZWNb11 Jul 2026 14:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mqet4zhlmm27https://bsky.app/profile/jamaoncology.com/post/3mqchoyhwlv2oAmong patients with advanced #BiliaryTractCancer, durvalumab plus gemcitabine and cisplatin provided sustained 4-year overall survival benefit and a comparable safety profile vs placebo plus chemotherapy ja.ma/4ygxazN10 Jul 2026 15:29 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mqchoyhwlv2ohttps://bsky.app/profile/jamaoncology.com/post/3mplefxaqlf2kGenomic profiling of consecutive meningiomas found associations between copy number alterations, somatic variants, tumor grade, and patient characteristics, offering insights into prognosis and therapeutic vulnerability. ja.ma/3SGkCRU01 Jul 2026 11:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mplefxaqlf2khttps://bsky.app/profile/jamaoncology.com/post/3mp534wtkmy2hPatients with platinum-sensitive recurrent #OvarianCancer and exceptional response to PARP inhibitors showed ≥78% ten-year progression-free survival, with low risk of myeloid cancers, regardless of maintenance duration. ja.ma/44AA3h325 Jun 2026 18:36 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mp534wtkmy2hhttps://bsky.app/profile/jamaoncology.com/post/3moutkxivza23The 9-valent #HPV vaccine was linked to reduced risk of #HPVRelatedCancers in males aged 9 to 26 years, with consistent protection in both the adolescent and young adult groups. ja.ma/4uPlDod22 Jun 2026 12:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3moutkxivza23https://bsky.app/profile/jamaoncology.com/post/3mos7qqn5lg2oPretreatment MRI findings including extraprostatic extension and seminal vesicle invasion were independently prognostic for recurrence, metastasis, and mortality after radical prostatectomy. #ProstateCancer ja.ma/4xGq5Ii21 Jun 2026 11:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mos7qqn5lg2ohttps://bsky.app/profile/jamaoncology.com/post/3moppbtladx2jClonal hematopoiesis of indeterminate potential (CHIP) was associated with higher risk of trastuzumab-related cardiotoxicity and heart failure in patients with #BreastCancer. ja.ma/446aHaZ20 Jun 2026 11:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3moppbtladx2jhttps://bsky.app/profile/jamaoncology.com/post/3monnvpijgx2oAmong adults with lymphoma or myeloma, second primary malignant neoplasms after T-cell–engaging bispecific antibody therapy occurred in 3.5%, with most second primary malignant neoplasms being skin or hematologic cancers. ja.ma/3SlsYOG19 Jun 2026 15:30 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3monnvpijgx2ohttps://bsky.app/profile/jamaoncology.com/post/3monma3cz3m2dA single-fraction 19 Gy SBRT regimen for localized #ProstateCancer achieved 92.9% 3-year biochemical relapse-free survival, with grade 2 genitourinary and gastrointestinal adverse event rates below 10% and 5%, respectively, at 3 years. ja.ma/4wjqpeX19 Jun 2026 15:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3monma3cz3m2dhttps://bsky.app/profile/jamaoncology.com/post/3mofqrgxldb2vSequential radiotherapy and immunotherapy (#iRT) provided longer overall survival than concurrent iRT for newly diagnosed advanced non–small cell lung cancer, with additional benefit from chemotherapy. ja.ma/4eOqlwD16 Jun 2026 12:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mofqrgxldb2vhttps://bsky.app/profile/jamaoncology.com/post/3mo6g3aloy62kA 58-year-old woman with #BreastCancer with multiple prior courses of systemic treatments presented with hypotension, hypoxia, significant polyuria, and polydipsia. Mild thickening of the pituitary stalk was seen. ✍️ What is your diagnosis? ja.ma/4vAqpXs13 Jun 2026 14:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mo6g3aloy62khttps://bsky.app/profile/jamaoncology.com/post/3mo3vme725m2uThis Special Communication provides consensus recommendations on the acquisition, interpretation, and reporting of prostate magnetic resonance imaging for cancer screening. ja.ma/4eApoJc12 Jun 2026 14:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mo3vme725m2uhttps://bsky.app/profile/jamaoncology.com/post/3mnzk6dystj2zAvelumab combined with methotrexate resulted in >95% durable remission and preserved #fertility in low-risk gestational trophoblastic #tumors, with a manageable safety profile. ja.ma/3RRcFcp11 Jun 2026 15:30 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mnzk6dystj2zhttps://bsky.app/profile/jamaoncology.com/post/3mnuaubgcq32pSequential radiotherapy and immunotherapy (#iRT) provided longer overall survival than concurrent iRT for newly diagnosed advanced non–small cell lung cancer, with additional benefit from chemotherapy. ja.ma/4oe1whI09 Jun 2026 13:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mnuaubgcq32phttps://bsky.app/profile/jamaoncology.com/post/3mnmsss655d2rAmong patients with early age–onset #ColorectalCancer in Texas, treatment delays longer than six weeks were associated with reduced survival, and language barriers represented a major risk factor contributing to delayed initiation of definitive therapy. ja.ma/3S1igN706 Jun 2026 14:00 +0000at://did:plc:rj6cle4uinetvpabgdddcemo/app.bsky.feed.post/3mnmsss655d2r