Systems Pharmacology and Biology Lab at @DepBiomedicine, University of Basel, Switzerland. We exploit metabolic weaknesses for therapeutic applications. www.zampierilab.orghttps://bsky.app/profile/zampierilab.bsky.socialhttps://bsky.app/profile/zampierilab.bsky.social/post/3mjjx2sxrps2tWelcome, Kevin Ritter, as a new PostDoc in our lab! He will be working on establishing in vitro frameworks to study metabolic reactions in defined biological extracts. With his background in organic chemistry, he will also reinforce our analytical expertise and help us set up our LC/MS workflow.15 Apr 2026 12:57 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3mjjx2sxrps2thttps://bsky.app/profile/zampierilab.bsky.social/post/3mjf65co54k2mIn today's journal club, we discussed a recent contribution from Michael Zimmermann's group @embl.org, Heidelberg, available on bioRxiv. Neat work illustrating the potential of individual members of the gut microbiome in drug-prodrug transformation impacting PK. https://www.biorxiv.org/content/10.64898/2025.12.09.692405v113 Apr 2026 15:20 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3mjf65co54k2mhttps://bsky.app/profile/zampierilab.bsky.social/post/3mhvalwfm4k27We are looking for an enthusiastic intern (100%) to work on extending our high-throughput metabolic fingerprinting platform into 3D cancer models, such as spheroids and organoids. Please apply here: https://jobs.unibas.ch/offene-stellen/internship-opportunity-zampieri-lab/c0cfa807-52fa-4197-83df-273bb83d4e3425 Mar 2026 13:56 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3mhvalwfm4k27https://bsky.app/profile/zampierilab.bsky.social/post/3mg5av6tubs2cWe discussed in our past journal club how Benztropine, a Parkinson’s drug, limits intracellular mycobacterium tuberculosis growth by modulating host histamine receptor H1, highlighting histamine signalling as a host-directed target. https://www.nature.com/articles/s44259-025-00143-x03 Mar 2026 07:32 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3mg5av6tubs2chttps://bsky.app/profile/zampierilab.bsky.social/post/3mf4w6w5oh22yThe Zampieri Lab at the University of Basel is recruiting a highly motivated PhD candidate to investigate how metabolic programs drive cancer metastasis. 📩 Only applications submitted through the official recruiting system of the University of Basel will be considered. https://jobs.unibas.ch/offene-stellen/phd-position-in-systems-biology-zampieri-lab/08024ca2-962e-4654-9a34-8afd1787418d18 Feb 2026 10:56 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3mf4w6w5oh22yhttps://bsky.app/profile/zampierilab.bsky.social/post/3mad72gzo5k2zWe have multiple open positions in our lab (www.zampierilab.org). Interested candidates should apply through the University of Basel’s official recruitment portal: https://www.unibas.ch/en/Working-at-the-University-of-Basel/Current-Vacancies.html https://www.zampierilab.org19 Dec 2025 07:44 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3mad72gzo5k2zhttps://bsky.app/profile/zampierilab.bsky.social/post/3mad6ftmcyc2z🎉 We’re excited to announce that Laurentz has been awarded the Research Fund for Excellent Junior Researchers 2025 of the University of Basel. As part of this project, we are now looking for a motivated intern: https://jobs.unibas.ch/offene-stellen/internship-opportunity-zampieri-lab/436b9a8d-2c0e-40de-a085-30069ea883ed19 Dec 2025 07:33 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3mad6ftmcyc2zhttps://bsky.app/profile/zampierilab.bsky.social/post/3m7ruwftios2nAfter our hike up the hills in Pratteln, we had a lovely evening out at Wystübli Leuengrund, enjoying a lot of 🧀 fondue and local wine 🥂.12 Dec 2025 10:28 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3m7ruwftios2nhttps://bsky.app/profile/zampierilab.bsky.social/post/3m76didejfc2lImpressive and interesting talks this week from our lab at the DBM monthly seminar series! Sebastian Bors and Tobias Fuhrer presented their projects and preliminary results, illustrating our lab's efforts to combine large screens with cell culture and high-throughput metabolomics.04 Dec 2025 15:55 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3m76didejfc2lhttps://bsky.app/profile/zampierilab.bsky.social/post/3m3oplhss5s2zIn this week’s journal club, we discussed how sugar-sweetened beverages - America’s sweetest legacy - may drive colorectal cancer metastasis. Glucose + fructose relieve CRC cells from NAD+ limitation through SORD to boost metastasis. https://www.nature.com/articles/s42255-025-01368-w21 Oct 2025 06:34 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3m3oplhss5s2zhttps://bsky.app/profile/zampierilab.bsky.social/post/3lzyjviwtxk2cIn our recent journal club, we discussed an impressive paper published in Nature Microbiology titled “A shared alarmone–GTP switch controls persister formation in bacteria”. A comprehensive work on a (p)ppGpp–GTP antagonism pathway! Check it out: https://doi.org/10.1038/s41564-025-02015-629 Sep 2025 17:28 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lzyjviwtxk2chttps://bsky.app/profile/zampierilab.bsky.social/post/3lxtqq7z2ak2zWe are happy to welcome Charleen Braun, doing her Master’s degree in Bioanalytics at Coburg University of Applied Sciences with a specialization in Human Biology.02 Sep 2025 08:57 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lxtqq7z2ak2zhttps://bsky.app/profile/zampierilab.bsky.social/post/3lwvjxyru5k2nAt our annual Summer Symposium, Laurentz Schuhknecht from our Lab received this year’s DBM Research Prize, for his groundbreaking work in drug discovery and systems pharmacology, published in Nature Biotechnology (Nature Portfolio) earlier this year. https://biomedizin.unibas.ch/en/communication/details/dbm-research-prize-winner-2024-2025/21 Aug 2025 08:36 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lwvjxyru5k2nhttps://bsky.app/profile/zampierilab.bsky.social/post/3lui5c7aaes2bIn our today's journal club, we discussed this impressive work by the Ralser Lab appearing this month in Nature: https://www.nature.com/articles/s41586-025-09205-621 Jul 2025 13:54 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lui5c7aaes2bhttps://bsky.app/profile/zampierilab.bsky.social/post/3lsva5knywc2hIn our recent journal club, we discussed insights obtained by in vivo NMR in the context of antibiotic resistance. Check it out! https://pubs.rsc.org/en/content/articlelanding/2025/ay/d4ay02023e01 Jul 2025 07:59 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lsva5knywc2hhttps://bsky.app/profile/zampierilab.bsky.social/post/3lrfgn3j4522zWe are happy to welcome Sandra Pflästerer, doing her Master’s degree in Molecular and Cellular Biology at Ludwig-Maximilian University.12 Jun 2025 07:48 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lrfgn3j4522zhttps://bsky.app/profile/zampierilab.bsky.social/post/3lq5ru5jaj227In our recent journal club, we discussed a nice publication from Nature: “Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses”. These exciting findings open the door to approaches that regulate immunometabolism during bacterial infections. https://www.nature.com/articles/s41586-025-08629-427 May 2025 13:22 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lq5ru5jaj227https://bsky.app/profile/zampierilab.bsky.social/post/3lpjimvmblk2eWe are looking for highly motivated Master and Bachelor Students to work on computational projects to better understand how bacteria and cancer cells metabolically adapt to chemical perturbations. Write us and find out how to conduct your semester or master project in our lab! www.zampierilab.org https://www.zampierilab.org19 May 2025 11:43 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lpjimvmblk2ehttps://bsky.app/profile/zampierilab.bsky.social/post/3lp27hcvz5k2eWe are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction. https://www.biorxiv.org/content/10.1101/2025.05.12.652188v113 May 2025 09:49 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lp27hcvz5k2ehttps://bsky.app/profile/zampierilab.bsky.social/post/3lm7ihrwcec2nA warm welcome to Dana Reddmann, Biochemistry Master's student at Freie Universität Berlin, starting her Master Thesis in our lab!07 Apr 2025 07:58 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lm7ihrwcec2nhttps://bsky.app/profile/zampierilab.bsky.social/post/3ll6r244vcs2bWe are happy to welcome Elena Pintea, MSc-Student in the Drug Sciences program at the University of Basel.25 Mar 2025 07:34 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3ll6r244vcs2bhttps://bsky.app/profile/zampierilab.bsky.social/post/3lk23abe5nc2nOur recent publication has been featured in The Scientist! Thanks to Sneha Khedkar for such a clear and exciting presentation of our research. https://www.the-scientist.com/same-drug-new-actions-metabolomics-reveals-hidden-drug-effects-7275510 Mar 2025 17:28 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lk23abe5nc2nhttps://bsky.app/profile/zampierilab.bsky.social/post/3ljieg2w2k22nIn today's journal club, we discussed the work by Sunil Guharajan, Vinuselvi Parisutham and Robert C. Brewster from @brewsterlab.bsky.social, which was recently published in Nucleic Acids Research. https://doi.org/10.1093/nar/gkaf05803 Mar 2025 16:24 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3ljieg2w2k22nhttps://bsky.app/profile/zampierilab.bsky.social/post/3ljiea62jxk2nA warm welcome to Thomas Gosselin-Monplaisir, visiting PhD-Student from Toulouse Biotechnology Institute.03 Mar 2025 16:21 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3ljiea62jxk2nhttps://bsky.app/profile/zampierilab.bsky.social/post/3lhy2ule4f22dWe are seeking for a talented semester or master student for a computational project on antimicrobial effects of drugs. Check it out! www.zampierilab.org/join-us/ https://www.zampierilab.org/join-us/12 Feb 2025 11:26 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lhy2ule4f22dhttps://bsky.app/profile/zampierilab.bsky.social/post/3lhgx7fa6ns2cOur work was featured in chemistryworld. Fantastic pitch of our research by Anthony King. https://www.chemistryworld.com/news/mapping-metabolite-disturbances-by-drugs/4020914.article05 Feb 2025 16:05 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lhgx7fa6ns2chttps://bsky.app/profile/zampierilab.bsky.social/post/3lhbynlzxes2cToday in our journal club: impressive work by the group of S.M. Fendt KU Leuven, published in Nature: https://www.nature.com/articles/s41586-024-08335-7 Here they present how elevated pulmonary aspartate levels trigger a translational program that boosts the aggressiveness of lung metastases.03 Feb 2025 16:47 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lhbynlzxes2chttps://bsky.app/profile/zampierilab.bsky.social/post/3lgsds6uhqk24We are very excited to share that the recent research from our lab has been published in Nature Biotechnology! Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research! https://www.nature.com/articles/s41587-024-02524-528 Jan 2025 11:24 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lgsds6uhqk24https://bsky.app/profile/zampierilab.bsky.social/post/3lbze6lsqp22gToday in our journal club: impressive work by Tofani et al. in Cell Metabolism. https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00399-128 Nov 2024 15:14 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lbze6lsqp22ghttps://bsky.app/profile/zampierilab.bsky.social/post/3lbzdvhozqk2qThis is our new lab profile on @bsky.app ! Stay tuned for regular news and updates from our lab!28 Nov 2024 15:09 +0000at://did:plc:rpt4gz52upktlg5o7l273jez/app.bsky.feed.post/3lbzdvhozqk2q