Cell Biologist and Neuroscientist at Yale University. Outdoor explorer.https://bsky.app/profile/shawnferguson.bsky.socialhttps://bsky.app/profile/shawnferguson.bsky.social/post/3mm553psjks2lLoon visited this morning18 May 2026 14:56 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3mm553psjks2lhttps://bsky.app/profile/shawnferguson.bsky.social/post/3mlyjphwfj22fNew to me. Painted trillium. Colton, NY16 May 2026 18:58 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3mlyjphwfj22fhttps://bsky.app/profile/shawnferguson.bsky.social/post/3mkgzahjmz22jRainy night friend27 Apr 2026 02:23 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3mkgzahjmz22jhttps://bsky.app/profile/shawnferguson.bsky.social/post/3mk7cuyp2wk26It was a pleasure to work with @laylanassar.bsky.social to highlight this paper from @spencerfreeman.bsky.social and colleagues that shows how lysosomes can adapt in response to increased membrane tension [contains quote post or other embedded content]24 Apr 2026 00:54 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3mk7cuyp2wk26https://bsky.app/profile/shawnferguson.bsky.social/post/3mk4hyite4c2gHow do lysosomes rapidly adapt to membrane tension to avoid bursting? In this article, @laylanassar.bsky.social and I highlight discoveries from Angela Kim, Spencer Freeman and colleagues who show a role for TMEM63A, a mechanosensitive cation channel in protecting lysosomes https://doi.org/10.1083/jcb.20260400922 Apr 2026 21:48 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3mk4hyite4c2ghttps://bsky.app/profile/shawnferguson.bsky.social/post/3mjkikqn2722xSpotted salamander eggs in a vernal pool. Killingworth, CT15 Apr 2026 18:10 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3mjkikqn2722xhttps://bsky.app/profile/shawnferguson.bsky.social/post/3mjkafzr6lk2xMy friends are out and about again! Spring has officially sprung in Connecticut! 🦎15 Apr 2026 15:44 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3mjkafzr6lk2xhttps://bsky.app/profile/shawnferguson.bsky.social/post/3mjivy7ds322lLast “ice neurons” of the year? Near Tupper Lake, NY last week15 Apr 2026 03:05 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3mjivy7ds322lhttps://bsky.app/profile/shawnferguson.bsky.social/post/3mih5xeg7ok2uThere are still spots available (get them while they last) for the 2026 Lysosomes and Endocytosis GRC (June 14-19, 2026). APPLY NOW if you are interested. Newcomers to the field or old friends, everyone is welcome! https://www.grc.org/lysosomes-and-endocytosis-conference/2026/01 Apr 2026 16:57 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3mih5xeg7ok2uhttps://bsky.app/profile/shawnferguson.bsky.social/post/3m7sgvohkbs25I am excited to be co-organizing the 2026 Gordon Research Conference on Lysosomes & Endocytosis continuing a community tradition that has now spanned more than 50 years. https://www.grc.org/lysosomes-and-endocytosis-conference/2026/12 Dec 2025 15:50 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3m7sgvohkbs25https://bsky.app/profile/shawnferguson.bsky.social/post/3m7jhiv67jk26New research led by Devin Clegg that defines how lysosome swelling and lysosome deacidification evoke distinct routes for LRRK2 activation: https://doi.org/10.1101/2025.11.19.68925109 Dec 2025 02:06 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3m7jhiv67jk26https://bsky.app/profile/shawnferguson.bsky.social/post/3lsrvgu6p722n30 Jun 2025 00:10 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3lsrvgu6p722nhttps://bsky.app/profile/shawnferguson.bsky.social/post/3lskglwkrkc2pConnecticut cactus flower season 🌵27 Jun 2025 00:55 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3lskglwkrkc2phttps://bsky.app/profile/shawnferguson.bsky.social/post/3lsajcpu4is26Carbide Wilson ruins. Gatineau Park, Quebec23 Jun 2025 02:17 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3lsajcpu4is26https://bsky.app/profile/shawnferguson.bsky.social/post/3lro4xlwux22kExploring Waterville Valley, NH15 Jun 2025 18:48 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3lro4xlwux22khttps://bsky.app/profile/shawnferguson.bsky.social/post/3lr6imxdfqk24I am excited to share our new preprint! Led by @laylanassar.bsky.social , we have found a new JIP4-dependent mechanism that controls the efflux of cystine from lysosomes. Our findings have implications for both lysosome biology and human disease: https://doi.org/10.1101/2025.06.06.65790909 Jun 2025 13:35 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3lr6imxdfqk24https://bsky.app/profile/shawnferguson.bsky.social/post/3lovxq3s5dc2dPink lady slipper orchid11 May 2025 17:20 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3lovxq3s5dc2dhttps://bsky.app/profile/shawnferguson.bsky.social/post/3lobsyisohc26Here’s a new set of discoveries led by Francesca Filippini: https://doi.org/10.1101/2025.05.02.651888 We found that LRP10 promotes the efficient delivery of progranulin to lysosomes and that microglia are particularly sensitive to loss of LRP10.03 May 2025 17:02 +0000at://did:plc:tc35wthuz5j2ohnbg2idsic2/app.bsky.feed.post/3lobsyisohc26