Professor & Program Head, Biostatistics, Fred Hutch | Donald and Janet K. Guthrie Endowed Chair in Statistics | Affiliate Professor, UW Biostat | Research: statistical methods for biomedical science, with a focus on rigor & reproducibility 🔗 jsb.ucla.eduhttps://bsky.app/profile/jsb-ucla.bsky.socialhttps://bsky.app/profile/jsb-ucla.bsky.social/post/3mtu5tk3ops2dMy postdoc Pan Liu will start this fall as Assistant Professor of Biostatistics at The University of Texas MD Anderson Cancer Center, where she will continue developing statistical methods for genomics and pursue broader questions in biostatistics such as clinical trials and AI.24 Aug 2026 20:37 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3mtu5tk3ops2dhttps://bsky.app/profile/jsb-ucla.bsky.social/post/3mtkyfupbfk261/5 New in Cell Systems: our commentary revisits a recent Nature debate over memory-associated gene-expression changes in single-cell data. The debate centered on whether reported differential-expression (DE) signals were statistically reliable.21 Aug 2026 05:06 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3mtkyfupbfk26https://bsky.app/profile/jsb-ucla.bsky.social/post/3mk7zjrfqw22gI am deeply honored by this recognition from the ISCB, which would not have been possible without the immense trust and hard work of my trainees. I am also thankful for the strong support of my colleagues and administrative team. [contains quote post or other embedded content]24 Apr 2026 07:40 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3mk7zjrfqw22ghttps://bsky.app/profile/jsb-ucla.bsky.social/post/3mdjyualtu22dI hope that Nullstrap-DE can be a useful add-on to calibrate the FDR control of popular parametric DE methods, including DESeq2 and edgeR, while maintaining the strong power. Looking forward to feedback and comments from the community. We will post the scDesignPop preprint soon. [contains quote post or other embedded content]29 Jan 2026 04:58 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3mdjyualtu22dhttps://bsky.app/profile/jsb-ucla.bsky.social/post/3m2rpwqlw6c2j1/3 Metacells boost power in single-cell RNA-seq & multiome analysis. But without checking homogeneity, they risk forming dubious metacells that bias discoveries. We introduce mcRigor: a statistical safeguard for rigorous metacell analysis. 👉 https://www.nature.com/articles/s41467-025-63626-509 Oct 2025 17:53 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3m2rpwqlw6c2jhttps://bsky.app/profile/jsb-ucla.bsky.social/post/3lu7vnrhzsk2lExcited to share our method ClipperQTL published in Genome Biology. Built on our p-value-free FDR control framework Clipper, ClipperQTL performs on par with FastQTL and runs up to 500× faster. Big thanks to my former PhD student Heather Zhou! https://genomebiology.biomedcentral.com/articles/10.1186/s13059-025-03662-y #eQTL18 Jul 2025 07:16 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3lu7vnrhzsk2lhttps://bsky.app/profile/jsb-ucla.bsky.social/post/3lsthgmif622vI’m honored to join Fred Hutch as Professor and Program Head of Biostatistics, and as the Donald and Janet K. Guthrie Endowed Chair in Statistics. Excited to be part of a deeply collaborative and scientifically vibrant community with a rich legacy of impact. @fredhutchbiostat.bsky.social30 Jun 2025 15:04 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3lsthgmif622vhttps://bsky.app/profile/jsb-ucla.bsky.social/post/3lrswoomqyc2pI’ll speak on July 16 (2:30pm ET) at NSF@75: Advancing Statistical Science for a Data‑Driven World Conference, by ASA & Instats My talk is about an info-theoretic criterion (ITCA) for combining ambiguous class labels: https://jmlr.org/papers/v23/21-1043.html Free registration: https://instats.org/seminar/nsfa75-advancing-statistical-science-for17 Jun 2025 16:39 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3lrswoomqyc2phttps://bsky.app/profile/jsb-ucla.bsky.social/post/3lmubac4hvk2a@guggfellows.bsky.social I’m deeply honored to be named a 2025 Guggenheim Fellow—especially as part of the Foundation’s historic 100th class. Grateful to be in the company of so many brilliant artists, scholars, and scientists. #guggfellows202515 Apr 2025 14:15 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3lmubac4hvk2ahttps://bsky.app/profile/jsb-ucla.bsky.social/post/3lhhdrrfe4d2dHow do we detect spatially variable genes (SVGs) in spatial transcriptomics? In our Nature Communications review, we categorize 34 computational methods into three categories: ✅ Overall SVGs ✅ Cell-type-specific SVGs ✅ Spatial-domain-marker SVGs https://www.nature.com/articles/s41467-025-56080-w05 Feb 2025 19:50 +0000at://did:plc:tdcfhso6he2tgy2fjaebrps6/app.bsky.feed.post/3lhhdrrfe4d2d