Acta Crystallographica Section F: Structural Biology Communications is a structural biology communications journal published by the IUCr. http://journals.iucr.org/fhttps://bsky.app/profile/actacrystf.iucr.orghttps://bsky.app/profile/actacrystf.iucr.org/post/3mlntltouvs2hIn the latest in our Interviews With Authors series, the Acta F Section Editors talk to Anuradha Pullakhandam and Charlie Bond about their review on 'Structures of pentatricopeptide repeat proteins'. Read the article at https://journals.iucr.org/f/issues/2026/04/00/ir5054/index.html https://www.youtube.com/watch?v=nYcFgDy21DM&list=PL6UK2yPUlpxqkSpHBXd6hs6eipOFx87QI&index=112 May 2026 12:56 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mlntltouvs2hhttps://bsky.app/profile/actacrystf.iucr.org/post/3ml6torkoj22uNew issue is out! https://journals.iucr.org/f/issues/2026/05/00/ On the cover: the atomic structure of human dystrophin spectrin-like repeat 24 determined at 2.14 Å resolution https://journals.iucr.org/f/issues/2026/05/00/rl5207/index.html06 May 2026 13:48 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3ml6torkoj22uhttps://bsky.app/profile/actacrystf.iucr.org/post/3ml6torkoj22uNew issue is out! https://journals.iucr.org/f/issues/2026/05/00/ On the cover: the atomic structure of human dystrophin spectrin-like repeat 24 determined at 2.14 Å resolution https://journals.iucr.org/f/issues/2026/05/00/rl5207/index.html06 May 2026 13:48 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3ml6torkoj22uhttps://bsky.app/profile/actacrystf.iucr.org/post/3mk6b3p4yy22xModifying the bacterial strain led to cleaner bacterial expression of a synthetic BRIL antibody that facilitates protein structure determination via both crystallography and cryo-EM #CryoEM #XRayCrystallography #BRIL https://doi.org/10.1107/S2053230X2600154823 Apr 2026 14:50 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mk6b3p4yy22xhttps://bsky.app/profile/actacrystf.iucr.org/post/3mk3qgyuuhk2eHigh-resolution structures of α-bCA2 with sulfonamide derivatives provides experimentally supported information defining their binding mode and supporting inhibitor optimization #CarbonicAnhydraseII #SulfonamideInhibitors #XRayCrystallography https://doi.org/10.1107/S2053230X2600212822 Apr 2026 14:46 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mk3qgyuuhk2ehttps://bsky.app/profile/actacrystf.iucr.org/post/3mjz6brlmdc2hAn acylated GLP-1/GIP analogue peptide forms a uniquely porous spiral crystal structure composed of clockwise-ascending monomers in a square pattern #GLP1 #Peptides #Crystallization https://doi.org/10.1107/S2053230X2600193721 Apr 2026 14:16 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mjz6brlmdc2hhttps://bsky.app/profile/actacrystf.iucr.org/post/3mjwovsxso22mA comprehensive survey catalogues all pentatricopeptide repeat protein crystal structures, analysing their crystallographic properties, structural features and contributions to understanding function #PentatricopeptideRepeatProteins #RNARecognition https://doi.org/10.1107/S2053230X2600231120 Apr 2026 14:35 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mjwovsxso22mhttps://bsky.app/profile/actacrystf.iucr.org/post/3miyhyrpeak24Our April issue is out now! https://journals.iucr.org/f/issues/2026/04/00/ Crystallization was investigated as a preparative strategy for a GLP-1/GIP lipopeptide and led to what is believed to be the first reported crystal structure of an unbound GLP-1/GIP analogue https://doi.org/10.1107/S2053230X2600193708 Apr 2026 14:12 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3miyhyrpeak24https://bsky.app/profile/actacrystf.iucr.org/post/3mhwfpsodsd23Abe, Fukui and Ogura: Crystal structure of PM1Pgh, a poly-γ-glutamate hydrolase from Bacillus phage PM1 #PolyGlutamateHydrolases #Pgh #BacteriophagePM1 @NaraWomensUniv...#IUCr https://journals.iucr.org/paper?S2053230X2600218926 Mar 2026 01:01 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mhwfpsodsd23https://bsky.app/profile/actacrystf.iucr.org/post/3mhgabuqsj226The structure of endo-β-N-acetylglucosaminidase was determined at 1.8 Å resolution, revealing a unique spatial arrangement of domain IV, which is suggested to contribute to substrate recognition #EndoNAcetylglucosaminidases #GH85 #ComplexNGlycans https://doi.org/10.1107/S2053230X2600121419 Mar 2026 14:41 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mhgabuqsj226https://bsky.app/profile/actacrystf.iucr.org/post/3mhdtpnjaqk25The structure of a chimeric efflux pump was determined by cryoEM under apo and kanamycin-supplemented conditions and adopted symmetric-like and asymmetric conformations #PseudomonasAeruginosa #DrugEffluxTransporters #MembraneProteins https://doi.org/10.1107/S2053230X2600120218 Mar 2026 15:51 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mhdtpnjaqk25https://bsky.app/profile/actacrystf.iucr.org/post/3mhcbxhei4y2oCooper and Isom: Optimized bacterial expression of a synthetic BRIL antibody #CryoEM #XRayCrystallography #BRIL @UniofOxford@UniofOxford...#IUCr https://journals.iucr.org/paper?S2053230X2600154818 Mar 2026 01:00 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mhcbxhei4y2ohttps://bsky.app/profile/actacrystf.iucr.org/post/3mhbc2jbnp22rMBP fusion is an effective and generalizable approach to enable crystallographic studies of engineered binding proteins that are otherwise difficult to crystallize #Monobody #Aggregation #MaltoseBindingProtein https://doi.org/10.1107/S2053230X2600079817 Mar 2026 15:29 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mhbc2jbnp22rhttps://bsky.app/profile/actacrystf.iucr.org/post/3mh7rkaap2n2cM​. Y. Stoliarskaia et al.: X-ray analysis of complexes of carbonic anhydrase II with 1,3-oxazole-containing sulfonamide derivatives elucidates the structural basis for their exceptionally high inhibitory potency ... #IUCr https://journals.iucr.org/paper?S2053230X2600212817 Mar 2026 01:01 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mh7rkaap2n2chttps://bsky.app/profile/actacrystf.iucr.org/post/3mh6olmzlhk2hThis report of the structure of a carbon-nitrogen hydrolase https://doi.org/10.1107/S2053230X26001330 is the first contribution to the Early Career Scientists in Structural Science special issue! Find out more, join in and submit at https://journals.iucr.org/early-career/special-issue-2026.html16 Mar 2026 14:35 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mh6olmzlhk2hhttps://bsky.app/profile/actacrystf.iucr.org/post/3mgn4redtbk22Here's our March issue: https://journals.iucr.org/f/issues/2026/03/00/ On the cover: the structure of the chimeric RND-type multidrug-efflux pump protein MexBYB was determined by cryoEM under apo and kanamycin-supplemented conditions https://journals.iucr.org/f/issues/2026/03/00/ek5041/index.html09 Mar 2026 15:01 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mgn4redtbk22https://bsky.app/profile/actacrystf.iucr.org/post/3mg73genlbk2pIkuya Kurauchi et al.: Crystal structure of endo-β-N-acetylglucosaminidase HSα #EndoNAcetylglucosaminidases #GH85 #ComplexNGlycans ... #IUCr https://journals.iucr.org/paper?S2053230X2600121404 Mar 2026 01:00 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mg73genlbk2phttps://bsky.app/profile/actacrystf.iucr.org/post/3mfsj55qkag2rJiye Wang et al.: Cryo-EM structures of a MexB–MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain #MembraneProteins #DrugEffluxTransporters @osaka_univ_e@UTokyo_News...#IUCr https://journals.iucr.org/paper?S2053230X2600120227 Feb 2026 01:01 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mfsj55qkag2rhttps://bsky.app/profile/actacrystf.iucr.org/post/3mf7yrhnixs23This structure of a tRNA acceptor-stem mimic demonstrates the use of bromine and phosphorus anomalous scattering for RNA structure determination #Crystallography #AnomalousScattering #NucleicAcids https://doi.org/10.1107/S2053230X2600065819 Feb 2026 16:20 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mf7yrhnixs23https://bsky.app/profile/actacrystf.iucr.org/post/3mf6fehyiju2eAruesha Srivastava et al.: Crystal structure of carbon–nitrogen hydrolase from Helicobacter pylori G27 #Ssgcid #StructuralGenomics #HelicobacterPylori @_hamptonu...#IUCr https://journals.iucr.org/paper?S2053230X2600133019 Feb 2026 01:00 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mf6fehyiju2ehttps://bsky.app/profile/actacrystf.iucr.org/post/3mf5bxqrcxc2ySample preparation from α- and β-crustacyanin pigments purified from ex vivo material from the American lobster Homarus americanus for X-ray crystallography and cryo-electron microscopy studies #Astaxanthin #Crustacyanin #Absorption https://doi.org/10.1107/S2053230X2600018X18 Feb 2026 14:27 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mf5bxqrcxc2yhttps://bsky.app/profile/actacrystf.iucr.org/post/3mf2uaunb5k2xThe highest resolution DNA-free TaXPD structure to date uniquely resolves loop 510–514 in the long-form, DNA-free TaXPD model #XRayCrystallography #Helicases #Archaea https://doi.org/10.1107/S2053230X2600010517 Feb 2026 15:16 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mf2uaunb5k2xhttps://bsky.app/profile/actacrystf.iucr.org/post/3meyc63guv222Potential 14-3-3 binding sites in sirtuins were identfied and the interactions of peptides representing phosphorylation sites in sirtuin 3 and sirtuin 1 with 14-3-3 proteins were characterized #Sirtuin #Phosphopeptides #Regulation https://doi.org/10.1107/S2053230X2501090816 Feb 2026 14:47 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3meyc63guv222https://bsky.app/profile/actacrystf.iucr.org/post/3meohbks5ts2lThe flexible loop in Methanococcus jannaschii dihydroorotase with substrate bound adopts both the loop-out and loop-in conformations #Dihydroorotase #MethanococcusJannaschii #PyrimidineBiosynthesis https://doi.org/10.1107/S2053230X2501055612 Feb 2026 16:52 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3meohbks5ts2lhttps://bsky.app/profile/actacrystf.iucr.org/post/3melopmb5zs2sThe crystal structure of the class IIIb chitinase from Crocus vernus is reported, together with in silico analyses of inhibitor interactions and antifungal and chitinase assays #CrocusVernus #Chitinase #TIM https://doi.org/10.1107/S2053230X2500972011 Feb 2026 14:27 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3melopmb5zs2shttps://bsky.app/profile/actacrystf.iucr.org/post/3mej7qslics2hSingle surface substitutions can mprove the crystallizability and diffraction properties of a flexible two-domain protein even if they increase the entropy of the residue #MultidomainProtein #PointMutation #ProteinCrystallization https://doi.org/10.1107/S2053230X2501041610 Feb 2026 14:54 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mej7qslics2hhttps://bsky.app/profile/actacrystf.iucr.org/post/3mehr6j5wux2kKoushirou Endo et al.: Crystallization and X-ray structure of a highly aggregation-prone monobody engineered for high-affinity small-molecule recognition #Monobody #Aggregation #MaltoseBindingProtein @nitechofficial...#IUCr https://journals.iucr.org/paper?S2053230X2600079810 Feb 2026 01:00 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mehr6j5wux2khttps://bsky.app/profile/actacrystf.iucr.org/post/3megmuemxvk25What are the effects of the presence of polyethylene glycol in macromolecular crystals? #PolyethyleneGlycol #Mechanism #Crystallization https://doi.org/10.1107/S2053230X2501043X09 Feb 2026 14:10 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3megmuemxvk25