Acta Crystallographica Section F: Structural Biology Communications is a structural biology communications journal published by the IUCr. http://journals.iucr.org/fhttps://bsky.app/profile/actacrystf.iucr.orghttps://bsky.app/profile/actacrystf.iucr.org/post/3muwowygy622tOur September issue is out! https://journals.iucr.org/f/issues/2026/09/00/ The cover shows the structure of the NKX2-1 homeodomain bound to a 19 bp DNA duplex containing two palindromically arranged NK2-recognition motifs. Read more at https://doi.org/10.1107/S2053230X2600746607 Sep 2026 14:13 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3muwowygy622thttps://bsky.app/profile/actacrystf.iucr.org/post/3muwowygy622tOur September issue is out! https://journals.iucr.org/f/issues/2026/09/00/ The cover shows the structure of the NKX2-1 homeodomain bound to a 19 bp DNA duplex containing two palindromically arranged NK2-recognition motifs. Read more at https://doi.org/10.1107/S2053230X2600746607 Sep 2026 14:13 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3muwowygy622thttps://bsky.app/profile/actacrystf.iucr.org/post/3mu2zdqezps2iWebCalEM is a browser-based tool that makes lattice-based pixel-size calibration a routine step in the cryo-EM workflow #CryoElectronMicroscopy #MagnificationCalibration #PixelSize https://doi.org/10.1107/S2053230X2600630827 Aug 2026 14:05 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mu2zdqezps2ihttps://bsky.app/profile/actacrystf.iucr.org/post/3mtyjz5xsns2sThe replacement of DTT with TCEP in the crystallization of human aldehyde oxidase provides a strategy to circumvent enzyme inactivation during crystallographic studies #HumanAldehydeOxidase #XRayCrystallography #TCEP https://doi.org/10.1107/S2053230X2600690426 Aug 2026 14:25 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mtyjz5xsns2shttps://bsky.app/profile/actacrystf.iucr.org/post/3mtvv4lvg6c2mThe crystal structure of LegY, a putative glycosidase effector from L. pneumophila, was determined to 1.46 Å resolution and is structurally assigned as a member of glycoside hydrolase family 15 #LegionellaPneumophila #BacterialToxin #Glycosidase https://doi.org/10.1107/S2053230X2600648525 Aug 2026 13:06 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mtvv4lvg6c2mhttps://bsky.app/profile/actacrystf.iucr.org/post/3mttfqs5hss2mWe would like to invite you to share protocols that will be useful to the community, and help maintain Acta Crystallographica Section F and and the other IUCr Journals as important references for how structural biology research is performed https://doi.org/10.1107/S2053230X2600696524 Aug 2026 13:26 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mttfqs5hss2mhttps://bsky.app/profile/actacrystf.iucr.org/post/3msxpy4u2qk2gPresenting the first article in our new 'Protocols' category: Helical reconstruction of amyloids in cryoSPARC #Amyloids #CryoEM #HelicalReconstruction https://doi.org/10.1107/S2053230X2600367513 Aug 2026 13:14 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3msxpy4u2qk2ghttps://bsky.app/profile/actacrystf.iucr.org/post/3msvarkrdv22dThe crystal structure of human DKK4-CRD1 determined at 1.83 Å resolution reveals a compact fold comprising N- and C-subdomains connected by a linker region and stabilized by five conserved disulfide bonds #WntSignaling #Dickkopf4 #CysteineRichDomain1 https://doi.org/10.1107/S2053230X2600633312 Aug 2026 13:37 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3msvarkrdv22dhttps://bsky.app/profile/actacrystf.iucr.org/post/3mssr7ofenk2dThe DUF2875 domain-containing T6SS adaptor protein Tla3 from Pseudomonas aeruginosa strain UCBPP-PA14 shows a thiolase-like fold, marked by a five-layered α–β–α–β–α core topology #T6SS #Adaptors #PseudomonasAeruginosa https://doi.org/10.1107/S2053230X2600576511 Aug 2026 13:53 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mssr7ofenk2dhttps://bsky.app/profile/actacrystf.iucr.org/post/3msq7uatxyk22The cytosolic Nudix-like domain of the CBASS effector EfCap16 from E. faecalis was determined. The characteristic Nudix-like fold supports classification of EfCap16 as a member of the Nudix superfamily #CBASS #NudixHydrolases #TransmembraneEffectors https://doi.org/10.1107/S2053230X2600528510 Aug 2026 13:37 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3msq7uatxyk22https://bsky.app/profile/actacrystf.iucr.org/post/3msg75x3bdk2aAugust issue is out! https://journals.iucr.org/f/issues/2026/08/00/ On the cover: the crystal structure of LegY, a putative glycosidase effector from Legionella pneumophila, shows high similarity to fungal glucoamylases but shares lower homology with known prokaryotic counterparts https://doi.org/10.1107/S2053230X2600648506 Aug 2026 13:58 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3msg75x3bdk2ahttps://bsky.app/profile/actacrystf.iucr.org/post/3msg75x3bdk2aAugust issue is out! https://journals.iucr.org/f/issues/2026/08/00/ On the cover: the crystal structure of LegY, a putative glycosidase effector from Legionella pneumophila, shows high similarity to fungal glucoamylases but shares lower homology with known prokaryotic counterparts https://doi.org/10.1107/S2053230X2600648506 Aug 2026 13:58 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3msg75x3bdk2ahttps://bsky.app/profile/actacrystf.iucr.org/post/3mrumnszmvk2oA new type of article for Acta F: Protocols The purpose of this new category is to provide to the reader procedures that are sufficiently detailed so other researchers can reproduce the described workflow. Find out more in 'Show me how it's done: introducing Protocols': https://doi.org/10.1107/S2053230X2600696530 Jul 2026 14:11 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mrumnszmvk2ohttps://bsky.app/profile/actacrystf.iucr.org/post/3mrrwfjfgvs2cWe're celebrating 20 years of Acta Crystallographica Section F!🎉🥳 Join us by contributing to our celebratory collection of articles, which is now open for submissions! Find out more at https://journals.iucr.org/special_issues/submit/2026/actaf20/29 Jul 2026 12:28 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mrrwfjfgvs2chttps://bsky.app/profile/actacrystf.iucr.org/post/3mrumnszmvk2oA new type of article for Acta F: Protocols The purpose of this new category is to provide to the reader procedures that are sufficiently detailed so other researchers can reproduce the described workflow. Find out more in 'Show me how it's done: introducing Protocols': https://doi.org/10.1107/S2053230X2600696530 Jul 2026 14:11 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mrumnszmvk2ohttps://bsky.app/profile/actacrystf.iucr.org/post/3mrrwfjfgvs2cWe're celebrating 20 years of Acta Crystallographica Section F!🎉🥳 Join us by contributing to our celebratory collection of articles, which is now open for submissions! Find out more at https://journals.iucr.org/special_issues/submit/2026/actaf20/29 Jul 2026 12:28 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mrrwfjfgvs2chttps://bsky.app/profile/actacrystf.iucr.org/post/3mqovtsvur22zA crystal structure of PLpro exhibits Ubl2 in two distinct conformations: the well characterized closed state, where Ubl2 is positioned near the PLpro domain, and an as yet uncharacterized open state #SARSCoV2 #PapainLikeProteases #Ubl2Domain https://doi.org/10.1107/S2053230X2600369915 Jul 2026 14:15 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mqovtsvur22zhttps://bsky.app/profile/actacrystf.iucr.org/post/3mqmkil72uc2rA new crystal structure of ApePCNA1 and the newly solved structure of the ApePCNA2 homotrimer allowed modeling of the ApePCNA1–ApePCNA2–ApePCNA3 heterotrimer #AeropyrumPernix #DNAReplication #ProliferatingCellNuclearAntigens https://doi.org/10.1107/S2053230X2600368714 Jul 2026 15:46 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mqmkil72uc2rhttps://bsky.app/profile/actacrystf.iucr.org/post/3mqjvl7kqkc2rThe crystal structure of GABA aminotransferase from A. thaliana and structural comparison supports the conclusion that it belongs to the class III aminotransferase family #ArabidopsisThaliana #CrystalStructure #GABAAminotransferase https://doi.org/10.1107/S2053230X2600345613 Jul 2026 14:27 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mqjvl7kqkc2rhttps://bsky.app/profile/actacrystf.iucr.org/post/3mq7ryly4ps24The molecular interactions of the insomnia drug vorenorexant with human orexin receptors were analysed through crystal structure analysis and docking simulations #Vornorexant #OrexinReceptors #CrystalStructure https://doi.org/10.1107/S2053230X2600343209 Jul 2026 13:56 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mq7ryly4ps24https://bsky.app/profile/actacrystf.iucr.org/post/3mq5gjpog5k2iThis structure of macrophage migration inhibitory factor is a contribution to our cross-journal Early Career Scientists in Structural Science special issue. Find out more at https://journals.iucr.org/early-career/special-issue-2026.html #SSGCID #MacrophageMigrationInhibitoryFactor https://doi.org/10.1107/S2053230X2600387008 Jul 2026 15:25 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mq5gjpog5k2ihttps://bsky.app/profile/actacrystf.iucr.org/post/3mq2tvmupb227July issue is out now! https://journals.iucr.org/f/issues/2026/07/00/ This month's cover star is the type VI secretion system adaptor protein Tla3 from Pseudomonas aeruginosa strain UCBPPPA14. Find out more about this structure at https://doi.org/10.1107/S2053230X2600576507 Jul 2026 14:47 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mq2tvmupb227https://bsky.app/profile/actacrystf.iucr.org/post/3mofxzbzke22qThe structure of spectrin-like repeat 24 of human dystrophin is in excellent agreement with the AlphaFold model, supporting AlphaFold modeling of all 24 dystrophin spectrin-like repeats #Dystrophin #SpectrinLikeRepeat #DuchenneMuscularDystrophy https://doi.org/10.1107/S2053230X2600326216 Jun 2026 14:09 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mofxzbzke22qhttps://bsky.app/profile/actacrystf.iucr.org/post/3mnzgp2jqbk25The structure of a complex between human RAGE ectodomain and S100A6 variant Y84C provides a possible model for S100 covalent homodimerization that is fully compatible with RAGE binding #S100Proteins #Cysteines #CovalentHomodimerization https://doi.org/10.1107/S2053230X2600299211 Jun 2026 14:27 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mnzgp2jqbk25https://bsky.app/profile/actacrystf.iucr.org/post/3mnwtcx2s2k26The first structure of a cold-active arginase reveals a modest reduction in structural rigidity associated with cold adaptation #ColdActiveEnzymes #Arginases #XRayCrystallography https://doi.org/10.1107/S2053230X2600309210 Jun 2026 13:35 +0000at://did:plc:tgnvtklt27rmqw4zcv27mebe/app.bsky.feed.post/3mnwtcx2s2k26