Associate Professor for Molecular Evolution at the University of Groningen. My group makes biomolecules to order by letting millions of them compete until a winner is crowned :) Sometimes it even works!https://bsky.app/profile/mayerlab.bsky.socialhttps://bsky.app/profile/mayerlab.bsky.social/post/3mvz3ec3yt22e🚨New preprint alert! What a difference one C-F bond can make!🚨 Fluoroacetate dehalogenases (FAcDs) are remarkably good at breaking C-F bonds. But add just ONE more C-F bond to the substrate and suddenly the enzyme is inhibited. So, what’s going on? (1/4) https://www.biorxiv.org/content/10.64898/2026.09.12.751135v121 Sep 2026 06:26 +0000at://did:plc:twpm53vedccsjgchlaan2nbs/app.bsky.feed.post/3mvz3ec3yt22ehttps://bsky.app/profile/mayerlab.bsky.social/post/3mqmivbweqs2tNew review out in Chemistry – A European Journal! Hybrid macrocyclic peptides: combining biological selection with synthetic chemistry to discover next-generation therapeutics. Why are hybrid macrocyclic peptides so exciting? 👇 (1/5) https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.7140814 Jul 2026 15:18 +0000at://did:plc:twpm53vedccsjgchlaan2nbs/app.bsky.feed.post/3mqmivbweqs2thttps://bsky.app/profile/mayerlab.bsky.social/post/3mdipdtlyw22k🥳🥳🥳 Our study on engineering enzymes to break C–F bonds is out in @angewandtechemie.bsky.social. Congrats to the brilliant & dedicated @suzannejansen.bsky.social for taking this step toward the remediation of #PFAS & other contaminating organofluorides! https://onlinelibrary.wiley.com/doi/10.1002/anie.20252423428 Jan 2026 16:35 +0000at://did:plc:twpm53vedccsjgchlaan2nbs/app.bsky.feed.post/3mdipdtlyw22khttps://bsky.app/profile/mayerlab.bsky.social/post/3mad5cluv522o📢 📢 📢 !!!Come and join us!! 📢 📢 📢 We are looking for a Postdoctoral Researcher with in-depth experience in next- and third-generation sequencing to help us understand the fitness landscapes of complex biomolecules! Please spread the word :) https://werkenbij.rug.nl/vacature/postdoctoral-researcher-next-gen-sequencing-for-machine-learning-guided-directed-evolution-1584/?lang=en19 Dec 2025 07:13 +0000at://did:plc:twpm53vedccsjgchlaan2nbs/app.bsky.feed.post/3mad5cluv522ohttps://bsky.app/profile/mayerlab.bsky.social/post/3m2nut2fy2k2oIs today the day for phosphoramidite chemistry and/or next-gen sequencing??? #nobel #chemistry08 Oct 2025 05:09 +0000at://did:plc:twpm53vedccsjgchlaan2nbs/app.bsky.feed.post/3m2nut2fy2k2ohttps://bsky.app/profile/mayerlab.bsky.social/post/3lu5kixni4s2iWith #PFAS and other organofluorides wreaking havoc, we set out to engineer natural defluorinases for man-made organofluorides. All credit goes to the amazing @suzannejansen.bsky.social, who has outdone herself in this project! (1/5) https://www.biorxiv.org/content/10.1101/2025.07.16.665192v117 Jul 2025 08:51 +0000at://did:plc:twpm53vedccsjgchlaan2nbs/app.bsky.feed.post/3lu5kixni4s2ihttps://bsky.app/profile/mayerlab.bsky.social/post/3lhwgucukrs2pTwo weeks ago, we had a great group outing, including a city tour through Utrecht, a Mario Kart Wii tournament, and some Rock Band Wii fun! I am truly privileged to work with such a group of talented, dedicated, and smart individuals.11 Feb 2025 19:55 +0000at://did:plc:twpm53vedccsjgchlaan2nbs/app.bsky.feed.post/3lhwgucukrs2phttps://bsky.app/profile/mayerlab.bsky.social/post/3lhw2apgyas25Hello world, hello BlueSky 🙂11 Feb 2025 16:09 +0000at://did:plc:twpm53vedccsjgchlaan2nbs/app.bsky.feed.post/3lhw2apgyas25