chem bio PhD student in the Doudna Lab @Berkeleyhttps://bsky.app/profile/owentuck.bsky.socialhttps://bsky.app/profile/owentuck.bsky.social/post/3micxioevt22uHonored and excited to join the 2026 cohort of Stanford Science Fellows! https://humsci.stanford.edu/feature/stanford-science-fellows-2026-cohort-announced31 Mar 2026 00:51 +0000at://did:plc:vbrbrvwutlevdl6m6zpba3tf/app.bsky.feed.post/3micxioevt22uhttps://bsky.app/profile/owentuck.bsky.social/post/3m5pa6ldwdc2eBeautiful preprint from Simone Evans et al. in Alex Gao's group looking at MBL/nuclease and other cool zymogens (pepco, EACC1) in antiphage defense systems. Great to see this paradigm extended - probably many more proteolytically activated effectors out there... https://www.biorxiv.org/content/10.1101/2025.11.14.688446v115 Nov 2025 22:21 +0000at://did:plc:vbrbrvwutlevdl6m6zpba3tf/app.bsky.feed.post/3m5pa6ldwdc2ehttps://bsky.app/profile/owentuck.bsky.social/post/3m5k6weal2k2wOur nuclease-protease story is out! We explored a fascinating case of coevolution and modularity in prokaryotic immune systems: https://www.science.org/doi/10.1126/science.aea8769 Thanks to wonderful coauthors/collaborators/friends, the whole @doudna-lab.bsky.social and everyone at @innovativegenomics.bsky.social13 Nov 2025 22:15 +0000at://did:plc:vbrbrvwutlevdl6m6zpba3tf/app.bsky.feed.post/3m5k6weal2k2whttps://bsky.app/profile/owentuck.bsky.social/post/3lv4hfqj7s22nExcited to finally share this work! We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts. tinyurl.com/2uwwy4ty https://tinyurl.com/2uwwy4ty29 Jul 2025 15:48 +0000at://did:plc:vbrbrvwutlevdl6m6zpba3tf/app.bsky.feed.post/3lv4hfqj7s22nhttps://bsky.app/profile/owentuck.bsky.social/post/3kmoblz7gqr25New preprint to share in my first bsky post! @benadler.bsky.social and I present a mechanism for Hachiman immunity. The punchline - Hachiman is a genome integrity sensor. https://www.biorxiv.org/content/10.1101/2024.02.29.582594v101 Mar 2024 23:39 +0000at://did:plc:vbrbrvwutlevdl6m6zpba3tf/app.bsky.feed.post/3kmoblz7gqr25