Global Clinical Program Lead – Late CVRM @AstraZeneca | Clinical Professor of Medicine @PennState | #MASH researcher | Tackling liver health through science & lifestyle | #LiverSky #MASLD #run #lift #yoga #snowboard #read #garden | views my ownhttps://bsky.app/profile/jonathanstinemd.bsky.socialhttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3lsmjbu2wxs2bCelebrated 8 incredible years of Stine Lab with a team lunch today! Grateful for the hard work, discoveries, and camaraderie that made our journey so impactful. Here’s to the science, the memories, and the friendships that last far beyond the lab. #MASLD #Research27 Jun 2025 20:49 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3lsmjbu2wxs2bhttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3lql5mlupgc2zThe muscle–adipose–liver axis is critical, yet underrecognized, in #MASLD. Sarcopenic obesity affects ~50% with #MASLD and drives ⬆️ ASCVD and liver fibrosis. Its time to standardize definitions and intervene early: https://link.springer.com/article/10.1007/s10620-025-09107-7t's01 Jun 2025 20:57 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3lql5mlupgc2zhttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3lpuikmsfus2mIt was an absolute delight to contribute to this high-impact work with @tom-marjot.bsky.social and @mattarmstrong95.bsky.social in which we review all things #MASLD and #Muscle! If you're looking for holiday weekend reading, look no further: https://journals.lww.com/hepcomm/pages/articleviewer.aspx?year=2025&issue=06010&article=00016&type=Fulltext @ebtapper.bsky.social23 May 2025 20:41 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3lpuikmsfus2mhttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3loywxpsdec2yNew review out! 🧬 Autophagy plays a key role in #MASLD, regulating lipid metabolism, insulin sensitivity & fibrosis. But effects vary by cell type. Precision targeting is key. Great work led by Prashant Nighot and Kofi Clarke Read here: https://sciencedirect.com/science/article/pii/S277257232500041X?via%3Dihub12 May 2025 21:45 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3loywxpsdec2yhttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3loyvyfcioc2oHeading to the PA State Capitol tomorrow to advocate for continued funding of PA CURE program. This is critical for advancing clinical and biomedical research in PA. This investment saves lives and is even more important given the status of federal research funding. #ResearchMatters #PublicHealth12 May 2025 21:27 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3loyvyfcioc2ohttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3lnglueikxc2x22 Apr 2025 21:13 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3lnglueikxc2xhttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3lmwly3kwic27#Exercise may protect the liver by blocking ferroptosis, a key cell death pathway in #MASLD. 🏃‍♀️🧬 New review highlights NRF2, GPX4, and iron regulation as targets. A fresh angle for #ExerciseIsMedicine and a possible link cellular senescence pubmed.ncbi.nlm.nih.gov/40206477/16 Apr 2025 12:32 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3lmwly3kwic27https://bsky.app/profile/jonathanstinemd.bsky.social/post/3lmrxlqjznk2eOk, I couldn't resist this trend any longer... I had to have ChatGPT make my action figure based on my bio and here is what it generated 😂 😂 😂14 Apr 2025 16:17 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3lmrxlqjznk2ehttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3llh3nglc422l🔥🆙 to publish alongside my pre-doc #HannahMohrMS in AP&T where we offer our 🧠🧠🧠 about time restricted feeding and #MASLD including commentary on the recently published CHRONO-NAFLD study Read the full paper here: https://onlinelibrary.wiley.com/doi/10.1111/apt.7007828 Mar 2025 15:05 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3llh3nglc422lhttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3lknuvdagok2uJoin us for Penn State Health MASH Day on June 12th for a high-yield medical conference covering the latest in MASLD/MASH diagnosis and management. Don't miss expert insights and practical takeaways! Register here: ce.med.psu.edu/mash/ It’s free! https://ce.med.psu.edu/mash/18 Mar 2025 14:28 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3lknuvdagok2uhttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3ljl25q2bac2uToday is #WorldObesityDay and a good reminder that obesity is a major driver of #MASLD affecting billions worldwide. The good news? #Lifestyle interventions work! #Exercise can reverse liver fat & improve metabolic health. Let’s turn awareness into action! #ExerciseIsMedicine04 Mar 2025 17:59 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3ljl25q2bac2uhttps://bsky.app/profile/jonathanstinemd.bsky.social/post/3ljakm2fpis2o🎙️ Just finished a great interview with HCPLive on the importance of a #multidisciplinary care model for #MASLD. Collaboration across specialties is key to improving outcomes and redefining liver care! #LiverHealth #TeamApproach 📢 Full thoughts here: https://www.hcplive.com/view/the-importance-multidisciplinary-masld-care-jonathan-stine-md-msc28 Feb 2025 13:54 +0000at://did:plc:vj4utefuhqh2lyaagfun6ieu/app.bsky.feed.post/3ljakm2fpis2o