Data Scientist at Novartis. Alumni from LCG-UNAM, DFCI and EMBL.https://bsky.app/profile/areyesq.bsky.socialhttps://bsky.app/profile/areyesq.bsky.social/post/3lwnvrrohgs2wOur study about splicing modulating compounds is out! Molecules like Branaplam tweak exon inclusion. We describe how RNA structure and sequence dependencies shape exon selectivity. We're even able to reprogram the specificity by co-treatment with modified U1 snRNAs. https://www.biorxiv.org/content/10.1101/2025.08.14.670273v118 Aug 2025 07:46 +0000at://did:plc:vjk3asg2vz44cjhvr37usm4v/app.bsky.feed.post/3lwnvrrohgs2whttps://bsky.app/profile/areyesq.bsky.social/post/3lmjwn4mpys22This paper is a great example of the use of multiomic/multimodal data from patient cohorts for target identification. All evidence pointing towards ZNF469 as a regulator of collagen in liver fibrosis. Lots of potential here! https://insight.jci.org/articles/view/182232/ga11 Apr 2025 11:39 +0000at://did:plc:vjk3asg2vz44cjhvr37usm4v/app.bsky.feed.post/3lmjwn4mpys22https://bsky.app/profile/areyesq.bsky.social/post/3lavb6q7jck2hHello bluesky!14 Nov 2024 06:44 +0000at://did:plc:vjk3asg2vz44cjhvr37usm4v/app.bsky.feed.post/3lavb6q7jck2h