Computational methods for epigenetic, CRISPR genome editing and single-cell genomics. Associate Professor at MGH / Harvard Medical School. http://pinellolab.orghttps://bsky.app/profile/lucapinello.bsky.socialhttps://bsky.app/profile/lucapinello.bsky.social/post/3maqjudtfgs271/ Thrilled to share our DNA-Diffusion paper, co-led by Lucas Ferreira and @ssenan.bsky.social is now out in @NatureGenet! New experimental results: STARR-Seq validation across 3 cell types (episomal) and EXTRA-Seq for endogenous activation of AXIN2, a leukemia protective gene! https://x.com/lucapinello/status/175350620308126547424 Dec 2025 15:02 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3maqjudtfgs27https://bsky.app/profile/lucapinello.bsky.social/post/3m3qtkrfiys2t🚨 Exciting opportunity! The Eric and Wendy Schmidt Center at the Broad Institute of MIT and Harvard is recruiting exceptional postdocs for 2026 at the intersection of ML/math and biomedicine. Shape the future of computational biology 🧵👇22 Oct 2025 02:50 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3m3qtkrfiys2thttps://bsky.app/profile/lucapinello.bsky.social/post/3m3aeo7gi5c2m🧬Excited to be at #ASHG2025! My lab is presenting 5 studies this week. Join us for talks and posters on #SingleCell #CRISPR, #DeepLearning & more! Thread below with all presentation details 👇15 Oct 2025 13:41 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3m3aeo7gi5c2mhttps://bsky.app/profile/lucapinello.bsky.social/post/3lug4npqz3k27Excited to be at #ISMBECCB2025! I'll be presenting at RegSys on "Learning the Regulatory Genome by Destruction and Creation" (Thursday 3:15PM in Room 11BC). I'm looking forward to connecting with both new and old friends throughout the conference! 🧬 #CRISPR #Genomics #Diffusion20 Jul 2025 18:37 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3lug4npqz3k27https://bsky.app/profile/lucapinello.bsky.social/post/3lr2nvumqr22o🧵 It's raining outside, perfect for some vibe coding... ☔ So I built something cool with @anthropic.com's Claude Desktop! Introducing Claude Text Editor - edit ANY text, ANYWHERE on macOS with Claude's help. No more copy-paste gymnastics! 🚀08 Jun 2025 00:58 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3lr2nvumqr22ohttps://bsky.app/profile/lucapinello.bsky.social/post/3lnkl2rxax22tGreat to see it finally out —such a fantastic collaboration with @bkleinstiver.bsky.social , @rachelsilverstein9.bsky.social and team! [contains quote post or other embedded content]24 Apr 2025 11:09 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3lnkl2rxax22thttps://bsky.app/profile/lucapinello.bsky.social/post/3ldya2zb32c2x1/ 🎄 What’s the best gift under the tree for a computational biologist? 🎁 A new experimental assay that refines our view of gene regulation: ACCESS-ATAC! This creative idea from Richard Sherwood was developed collaboratively between his lab and mine. #Genomics https://www.biorxiv.org/content/10.1101/2024.12.17.628768v123 Dec 2024 15:18 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3ldya2zb32c2xhttps://bsky.app/profile/lucapinello.bsky.social/post/3ldli3cbrjc2eExcited to be visiting Duke University to share insights on computational methods for single-cell genomics and CRISPR genome editing! Thank you for hosting me @yi-zhang-compbio.bsky.social 🙏 [contains quote post or other embedded content]18 Dec 2024 13:37 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3ldli3cbrjc2ehttps://bsky.app/profile/lucapinello.bsky.social/post/3ldho4rbdcs25Amazing new assay that allows testing of multiple DNA sequences, similar to MPRA, but in an endogenous setting. Incredible potential! Congrats @jk-swietek.bsky.social , @bartdeplancke.bsky.social and the entire team – grateful and lucky to be an early adopter. Check it out! [contains quote post or other embedded content]17 Dec 2024 01:14 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3ldho4rbdcs25https://bsky.app/profile/lucapinello.bsky.social/post/3lcxyqvfcxc2vAttending #NeurIPS2024 this week and excited to connect with anyone exploring the intersection of #GenerativeAI, #DeepLearning, and #Genomics! I’m presenting our DNA-diffusion work at the LatinX in AI workshop today at 2:30—drop by if you’re around. Looking forward to meeting and learning from you!10 Dec 2024 19:42 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3lcxyqvfcxc2vhttps://bsky.app/profile/lucapinello.bsky.social/post/3lccnnmouv227Excited to visit the @humantechnopole.bsky.social 🇮🇹today to share our work on computational approaches in functional genomics! Looking forward to discussions with amazing scientists about #singlecell, #CRISPR, and #syntheticbiology. 🧬Special thanks to @nicolesoranzo for the invitation 🙏02 Dec 2024 07:57 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3lccnnmouv227https://bsky.app/profile/lucapinello.bsky.social/post/3lbgd6w3ss22xHello World! Very glad to be here and see the scientific community growing 🌱. It’s so refreshing to scroll through a feed full of exciting science! Looking forward to reconnecting with old friends and collaborators and meeting new ones. Let’s keep the science flowing! 🌟21 Nov 2024 01:35 +0000at://did:plc:vjmfmtm5zpol6k23jtcaftq3/app.bsky.feed.post/3lbgd6w3ss22x