Group leader @embl.org European Molecular Biology Laboratory #RNA biology | #single-molecule #biophysics | #structural biology | #biochemistry | #quantitative biology | #chemical biology | #synthetic biology - https://www.embl.org/groups/duss/https://bsky.app/profile/olivierduss.bsky.socialhttps://bsky.app/profile/olivierduss.bsky.social/post/3mi7gxubudk22Paraspeckle condensation is controlled via TDP-43 polymerization and linked to neuroprotection! https://www.nature.com/articles/s41556-026-01895-y Excellent work from Tatyana Shelkovnikova Lab in @natcellbio.nature.com in collaboration @embl.org29 Mar 2026 15:17 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3mi7gxubudk22https://bsky.app/profile/olivierduss.bsky.social/post/3mi7eslpyi22dUsing #SingleMolecule imaging we find that TFs: -boost co-transcriptional #ribosomal #RNA processing! -their binding #dynamics fundamentally differ for mRNA (transient) versus rRNA #transcription (stable)! @biorxivpreprint.bsky.social Anastasiia Chaban @embl.org https://www.biorxiv.org/content/10.64898/2026.03.17.712431v129 Mar 2026 14:38 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3mi7eslpyi22dhttps://bsky.app/profile/olivierduss.bsky.social/post/3mhvo2stwac2zMy first PhD student‘s, Kavan Gor, paper on 5-color single-molecule imaging of co-transcriptional RNA folding is out in @science.org Advances! He finds how RNA modification enzymes, antisense oligonucleotides and ribosomal proteins re-route nascent RNA folding. See more details in EMBL post below! [contains quote post or other embedded content]25 Mar 2026 17:57 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3mhvo2stwac2zhttps://bsky.app/profile/olivierduss.bsky.social/post/3m62srmqe4k25Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg! Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts! [contains quote post or other embedded content]20 Nov 2025 12:53 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3m62srmqe4k25https://bsky.app/profile/olivierduss.bsky.social/post/3m52fpxppms2sThe story of how multiple RBPs cooperate to repress translation is now out in @cp-cellreports.bsky.social by @marcopayr.bsky.social and in a great collaboration with @hennig-lab.bsky.social! https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2901263-X [contains quote post or other embedded content]07 Nov 2025 15:34 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3m52fpxppms2shttps://bsky.app/profile/olivierduss.bsky.social/post/3m525n54by22mThinking Like a Scientist, Part Two: The Omics Illusion https://network.febs.org/posts/thinking-like-a-scientist-part-two-the-omics-illusion #FEBSnet07 Nov 2025 13:10 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3m525n54by22mhttps://bsky.app/profile/olivierduss.bsky.social/post/3m4kclkdwb22dExcited to share my first PhD student’s @biorxivpreprint.bsky.social! Tracking 5 dyes simultaneously Kavan Gor @embl.org tracks nascent #RNA folding during #ribosome assembly to correlate structural with functional information on single RNA molecules! Check it out! https://www.biorxiv.org/content/10.1101/2025.10.23.684182v101 Nov 2025 05:56 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3m4kclkdwb22dhttps://bsky.app/profile/olivierduss.bsky.social/post/3lny4rjuzk22sThe timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs! https://www.biorxiv.org/content/10.1101/2025.04.27.650906v129 Apr 2025 20:31 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3lny4rjuzk22shttps://bsky.app/profile/olivierduss.bsky.social/post/3lmmgkmptrc27Ever wondered how several individual RBPs cooperate to repress translation? Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time! https://www.biorxiv.org/content/10.1101/2025.04.07.647595v1 [contains quote post or other embedded content]12 Apr 2025 11:29 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3lmmgkmptrc27https://bsky.app/profile/olivierduss.bsky.social/post/3lczatptl7c2tExcited to share our new work on the earliest steps of Pol-III transcription: We provide structural and kinetic insights into tRNA promoter engagement by yeast transcription factor TFIIIC ! Cool collaboration with the Müller and Eustermann Labs @embl.org ! https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1174/7919513?login=true11 Dec 2024 07:39 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3lczatptl7c2thttps://bsky.app/profile/olivierduss.bsky.social/post/3lcizvzuw7c2iFirst paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo004 Dec 2024 20:53 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3lcizvzuw7c2ihttps://bsky.app/profile/olivierduss.bsky.social/post/3lchr2gthv22tVery grateful to get support from the #ERC Consolidator grant! -to study how #transcription, #translation and #DNA repair cooperate -combining #single-molecule #microscopy in vitro & live cells and #cryoET -obtaining a real-time movie 🎥 🎞️ -hiring soon @embl.org! https://www.embl.org/news/awards-honours/three-embl-scientists-awarded-erc-consolidator-grants/04 Dec 2024 08:41 +0000at://did:plc:vn6k6b4ececo2iz3arv53fuu/app.bsky.feed.post/3lchr2gthv22t