Exploring the dual nature of signals, particularly Wnt signaling, in homeostasis and cancer using organoids and proteomics to uncover patient-specific mechanisms. Founder of Laigo Bio. Center for Molecular Medicine | Oncode Institute | madelonmauricelab.nlhttps://bsky.app/profile/mauricelab.bsky.socialhttps://bsky.app/profile/mauricelab.bsky.social/post/3mgwswuwpx22tIn our new iScience paper we find that WNT7B marks specific pancreatic tumour cells that maintain a basal like state and correlate with more aggressive disease. WNT-high cells support the survival of neighbouring cells through cell-cell contact-dependent signalling. https://doi.org/10.1016/j.isci.2026.11505013 Mar 2026 11:32 +0000at://did:plc:vtntvs7mxntugqstrwel75a2/app.bsky.feed.post/3mgwswuwpx22thttps://bsky.app/profile/mauricelab.bsky.social/post/3mg5mu244ek2h🚀 Big news from the Maurice lab! OutMARCH has secured an EIC Pathfinder grant to develop SureTACs, bispecific antibodies that degrade cancer driving membrane proteins, including previously undruggable targets. A new precision strategy to overcome therapy resistance in cancer. Thread 👇03 Mar 2026 11:07 +0000at://did:plc:vtntvs7mxntugqstrwel75a2/app.bsky.feed.post/3mg5mu244ek2hhttps://bsky.app/profile/mauricelab.bsky.social/post/3lwbqjpdupk2zJelte van der Vaart, postdoc in our lab, has been awarded an NWO Veni grant! 🎉 He will develop human adrenal organoids to uncover how hormone producing cells change identity and function, shedding light on endocrine health. We're so proud of his achievement and will support him along the way 😁13 Aug 2025 11:40 +0000at://did:plc:vtntvs7mxntugqstrwel75a2/app.bsky.feed.post/3lwbqjpdupk2zhttps://bsky.app/profile/mauricelab.bsky.social/post/3lonft2o7fs2xYesterday, @antonvenhuizen.bsky.social successfully defended his thesis "Molecular mechanisms of the β-catenin destruction complex in health and disease", which describes the versatile field of WNT regulator AXIN1. We are super proud and wish Dr. Venhuizen all the best in Cambridge!08 May 2025 07:39 +0000at://did:plc:vtntvs7mxntugqstrwel75a2/app.bsky.feed.post/3lonft2o7fs2xhttps://bsky.app/profile/mauricelab.bsky.social/post/3lguxgg3p4s2pWant to learn the latest insights on how Wnt signaling controls cell behavior? Check out a new review by Madelon Maurice (@madelonmaurice.bsky.social) and Stephane Angers at @natrevmcb.bsky.social [contains quote post or other embedded content]29 Jan 2025 12:21 +0000at://did:plc:vtntvs7mxntugqstrwel75a2/app.bsky.feed.post/3lguxgg3p4s2phttps://bsky.app/profile/mauricelab.bsky.social/post/3ldwazdf7us2mPre-print Alert! 📢 Proud to share our insights on WNT7B driving pancreatic cancer progression. Sprangers et al uses organoids to show that WNT7B employs short-range signaling driving tumor growth and mediate a shift of PDAC cells towards a more aggressive phenotype https://www.biorxiv.org/content/10.1101/2024.12.18.628910v122 Dec 2024 20:30 +0000at://did:plc:vtntvs7mxntugqstrwel75a2/app.bsky.feed.post/3ldwazdf7us2mhttps://bsky.app/profile/mauricelab.bsky.social/post/3ldnqkuhspc2p🎉 Huge congratulations to Dr. Joep Sprangers! Yesterday, Joep successfully defended his PhD thesis and officially became a doctor! His studies describe the role of WNT7B and WNT10A in regeneration, homeostasis, and cancer. It was a very special day, couldn’t be prouder.19 Dec 2024 11:14 +0000at://did:plc:vtntvs7mxntugqstrwel75a2/app.bsky.feed.post/3ldnqkuhspc2phttps://bsky.app/profile/mauricelab.bsky.social/post/3lczntplug223Yesterday, our lab turned festive for late Sinterklaas/early Christmas! 🎁 With poems, laughter, and guessing games, we shared stories, gifts, and some surprising personal details. Add drinks, snacks, and a digital fireplace, and it was a night of bonding, cheer, and fun!✨#LifeOutsideTheLab11 Dec 2024 11:32 +0000at://did:plc:vtntvs7mxntugqstrwel75a2/app.bsky.feed.post/3lczntplug223https://bsky.app/profile/mauricelab.bsky.social/post/3lcuo47z2hw26Our first post on BlueSky is here 🦋. Great story from @antonvenhuizen.bsky.social from our lab describing the role of AXIN1 mutations in hepatocellular carcinoma. Congrats to Anton for the hard work and the deserved BioRxiv pre-publication! 🥳 https://www.biorxiv.org/content/10.1101/2024.11.28.625941v1 [contains quote post or other embedded content]09 Dec 2024 11:53 +0000at://did:plc:vtntvs7mxntugqstrwel75a2/app.bsky.feed.post/3lcuo47z2hw26