Family | Music | Film | Surfing | http://imdb.me/greghayes | aKD #MIS_C #MISC May2020 #longcovidkidshttps://bsky.app/profile/soundgmh.bsky.socialhttps://bsky.app/profile/soundgmh.bsky.social/post/3mtuwvozquc24Multicenter international cohort study of haploinsufficiency of A20 reveals novel genetic architecture and phenotypic evolution - Journal of Allergy and Clinical Immunology https://www.jacionline.org/article/S0091-6749%2826%2900083-7/fulltext25 Aug 2026 04:05 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3mtuwvozquc24https://bsky.app/profile/soundgmh.bsky.social/post/3mfbiaoe2y22eWhile it suggests ways to treat autoimmune diseases, this mechanism may be relevant to the autoinflammatory end of the spectrum—and the immunological continuum in between. Think: diseases where ongoing durable cytokine signaling lowers “flare” thresholds across pathways. 1/2 [contains quote post or other embedded content]20 Feb 2026 06:30 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3mfbiaoe2y22ehttps://bsky.app/profile/soundgmh.bsky.social/post/3mf23uc653s2eTiming of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3‐Inflammasome Activation in Macrophages https://pmc.ncbi.nlm.nih.gov/articles/PMC12862736/17 Feb 2026 07:59 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3mf23uc653s2ehttps://bsky.app/profile/soundgmh.bsky.social/post/3m7qzpnuqfk2m—Long-Term Outcomes of COVID-19 Multisystem Inflammatory Syndrome in Children (MIS-C): A 4.5-Year Observational Study — MIS-C survivors face markedly elevated long-term multisystem risks, challenging the notion of full recovery #LongCovidKids12 Dec 2025 02:21 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3m7qzpnuqfk2mhttps://bsky.app/profile/soundgmh.bsky.social/post/3m74yfje2z22hAvian coronavirus IBV-induced activation of the NLRP3–Caspase-1–IL-1β axis in renal collecting ducts contributes to nephropathogenesis https://journals.asm.org/doi/10.1128/jvi.01466-2504 Dec 2025 03:04 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3m74yfje2z22hhttps://bsky.app/profile/soundgmh.bsky.social/post/3m5mdnwtdcs2chttps://www.science.org/doi/10.1126/scitranslmed.ady021014 Nov 2025 18:45 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3m5mdnwtdcs2chttps://bsky.app/profile/soundgmh.bsky.social/post/3m4wbw7wxms2uHuman genetic errors of immunity illuminate an adaptive arsenal model of rapid defenses https://www.cell.com/trends/immunology/abstract/S1471-4906(23)00266-106 Nov 2025 00:16 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3m4wbw7wxms2uhttps://bsky.app/profile/soundgmh.bsky.social/post/3m4qspysfx22yThis paper strongly echoes the framework I have been developing and publicly advocating for over the last five years. #MISC #KD #LongCovidKids [contains quote post or other embedded content]03 Nov 2025 20:00 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3m4qspysfx22yhttps://bsky.app/profile/soundgmh.bsky.social/post/3m4odtuvgck25Multisystem inflammatory syndrome in children is a SARS-CoV-2 triggered Kawasaki disease https://www.nature.com/articles/s41390-025-04499-802 Nov 2025 20:29 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3m4odtuvgck25https://bsky.app/profile/soundgmh.bsky.social/post/3m2nslxmx422zGut microbiota alterations are linked to COVID-19 severity in North African and European populations https://www.nature.com/articles/s41522-025-00733-708 Oct 2025 04:30 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3m2nslxmx422zhttps://bsky.app/profile/soundgmh.bsky.social/post/3m246a43rdk2qNLRP3 as a protein thermosensor ! [contains quote post or other embedded content]01 Oct 2025 04:10 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3m246a43rdk2qhttps://bsky.app/profile/soundgmh.bsky.social/post/3lzyi6p6gh22rCommon mechanisms across MIS-C, KD & IBD → the gut as a central driver Great perspective from @sanchoshimizu.bsky.social — Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases https://journals.biologists.com/dmm/article/18/9/dmm052439/369194/Unravelling-T-cell-dysregulation-in-the-gut-and29 Sep 2025 16:57 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3lzyi6p6gh22rhttps://bsky.app/profile/soundgmh.bsky.social/post/3ly4dd6cvtk2qAn RGD motif on SARS-CoV-2 Spike induces TGF-β signaling and downregulates interferon | Journal of Virology From spike to suppression: the RGD motif fuels TGF-β and disables antiviral immunity #PASC #LONGCOVID https://journals.asm.org/doi/10.1128/jvi.00435-2505 Sep 2025 18:51 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3ly4dd6cvtk2qhttps://bsky.app/profile/soundgmh.bsky.social/post/3lxyg6uvjzc2jHow interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease | Review https://www.sciencedirect.com/science/article/pii/S096800042500184704 Sep 2025 05:31 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3lxyg6uvjzc2jhttps://bsky.app/profile/soundgmh.bsky.social/post/3lxxzepudwk2fAuto-inflammation isn’t confined to rare syndromes. It can also be innate immune hypersensitivity / dysfunction expressed across a spectrum — from monogenic diseases like CAPS, through post-infectious syndromes like MIS-C and KD, to chronic conditions like ME/CFS and Long Covid. [contains quote post or other embedded content]04 Sep 2025 01:42 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3lxxzepudwk2fhttps://bsky.app/profile/soundgmh.bsky.social/post/3lxxzcq44t22fhttps://www.publichealth.columbia.edu/news/overactive-immune-system-seen-patients-chronic-fatigue-syndrome-me-cfs https://www.nature.com/articles/s44324-025-00079-w04 Sep 2025 01:41 +0000at://did:plc:vtsllilwcap4ubc7xempva4g/app.bsky.feed.post/3lxxzcq44t22f