https://bsky.app/profile/fdadf.bsky.socialhttps://bsky.app/profile/fdadf.bsky.social/post/3mvhzlp3ud22l🚨 Can DNA that does nothing become a cell’s Achilles’ heel? 🧬 Cas9 selectively killed human cells carrying a non-functional target sequence, sparing cells without it. https://www.sciencedirect.com/science/article/pii/S1568786425000369 #CRISPR #DNARepair14 Sep 2026 11:39 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3mvhzlp3ud22lhttps://bsky.app/profile/fdadf.bsky.social/post/3mtjjv6bjh223🚨 Can broken DNA generate a new protein? Our study independently confirms that DSBs trigger transcription from the break—and shows, for the first time, that the resulting RNA can be translated. Could this generate neoantigens after radio/chemotherapy? https://www.nature.com/articles/s42003-026-10230-y20 Aug 2026 15:13 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3mtjjv6bjh223https://bsky.app/profile/fdadf.bsky.social/post/3mt2dbimu3k2i#IPF has no cure. Median survival: 4 years. Lung transplant is the only real option. Our new paper shows this might be about to change. 🧵14 Aug 2026 14:05 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3mt2dbimu3k2ihttps://bsky.app/profile/fdadf.bsky.social/post/3mpjwpb3xxk2yThe work spans: • Telomere Biology Disorder (#TBD) mice • Physiologically aged mice • Human hematopoietic stem/progenitor cells from healthy elderly donors https://www.nature.com/articles/s43587-026-01136-930 Jun 2026 21:22 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3mpjwpb3xxk2yhttps://bsky.app/profile/fdadf.bsky.social/post/3mpjwo4lr5k2yhttps://www.nature.com/articles/s43587-026-01136-9 Using telomeric #antisense #oligonucleotides (tASOs)vwe restored hematopoietic #stem cell fitness, improved #vaccination responses, reduced #senescence and #inflammation, and improved the function of aged human hematopoietic stem cells. Without elongating #telomeres. https://www.nature.com/articles/s43587-026-01136-9Using30 Jun 2026 21:21 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3mpjwo4lr5k2yhttps://bsky.app/profile/fdadf.bsky.social/post/3mpjwgcshyk2yWhat drives the pathological consequences of #telomere dysfunction? So far elomere shortening has been considered the central issue. In our new nataging.nature.com study, we show that telomeric DNA damage signalling itself is a causal driver of hematopoietic decline. https://www.nature.com/articles/s43587-026-01136-930 Jun 2026 21:17 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3mpjwgcshyk2yhttps://bsky.app/profile/fdadf.bsky.social/post/3mdpj3facrs2bHappy to share our deep characterization of #LLPS events modulating the DNA damage response (#DDR) through #53BP1 condensation promoted by #dincRNA https://www.biorxiv.org/content/10.64898/2026.01.30.702603v131 Jan 2026 09:31 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3mdpj3facrs2bhttps://bsky.app/profile/fdadf.bsky.social/post/3lzdlo4gw7k2wembopress.org/doi/full/10.10… Today on World Alzheimer's Day we published in @EMBO Journal that #Alzheimer's diseases (#AD) is associated with DNA damage at #telomeres and that inhibition of telomeric DNA damage signaling with telomeric #ASO improves neurons cell viability https://embopress.org/doi/full/10.10…21 Sep 2025 09:34 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3lzdlo4gw7k2whttps://bsky.app/profile/fdadf.bsky.social/post/3lmuuupugpk2yhttps://www.semm.it/education/open-positions Join us!15 Apr 2025 20:06 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3lmuuupugpk2yhttps://bsky.app/profile/fdadf.bsky.social/post/3lkszvenl2k27Here is the link rdcu.be/eb9Kq for everybody to read our most recent Review on #aging and #cancer published in Nature Aging coauthored with Lucrezia Trastus - happy to read your comments. www.nature.com/articles/s43587-025-00827-z https://rdcu.be/eb9Kq20 Mar 2025 15:40 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3lkszvenl2k27https://bsky.app/profile/fdadf.bsky.social/post/3ljwtoc6j2c2xI had the incredible opportunity to speak at #TEDxRoma. It was an intense and unforgettable experience. If you attended or watched the talk, feel free to share your thoughts with me! #Aging #longevity #telomere https://youtu.be/yTGj-5BVLXs?feature=shared09 Mar 2025 10:35 +0000at://did:plc:we5gpscevisotbxvedminnnl/app.bsky.feed.post/3ljwtoc6j2c2x