Theoretical and experimental immunologist working in cancer research. Moffitt Cancer Centerhttps://bsky.app/profile/kimberly-luddy.bsky.socialhttps://bsky.app/profile/kimberly-luddy.bsky.social/post/3mqd7kzvd7k2yI keep thinking about this paper by @rrockne.bsky.social and others at City of Hope. This feels foundational in a way I can't explain yet. Ligand discrimination in immune cells: Signal processing insights into immune dysfunction in ER+ breast cancer https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.101361510 Jul 2026 22:37 +0000at://did:plc:wkulybs56ascejbjdhh3fxbe/app.bsky.feed.post/3mqd7kzvd7k2yhttps://bsky.app/profile/kimberly-luddy.bsky.social/post/3mog7ethlbc2mAre biological systems poised at criticality? arxiv.org/abs/1012.2242 https://arxiv.org/abs/1012.224216 Jun 2026 16:21 +0000at://did:plc:wkulybs56ascejbjdhh3fxbe/app.bsky.feed.post/3mog7ethlbc2mhttps://bsky.app/profile/kimberly-luddy.bsky.social/post/3m7knldekg22gNSD2 targeting reverses plasticity and drug resistance in prostate cancer https://www.nature.com/articles/s41586-025-09727-z09 Dec 2025 13:28 +0000at://did:plc:wkulybs56ascejbjdhh3fxbe/app.bsky.feed.post/3m7knldekg22ghttps://bsky.app/profile/kimberly-luddy.bsky.social/post/3lvno6ujr322rThe DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00854-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS221112472500854X%3Fshowall%3Dtrue05 Aug 2025 12:05 +0000at://did:plc:wkulybs56ascejbjdhh3fxbe/app.bsky.feed.post/3lvno6ujr322r