News feed for the Mugridge Lab in the Department of Chemistry & Biochemistry @UDelaware. We study the structural and biochemical mechanisms that control RNA modification and function in the cell. PI: @jeffmugridge.bsky.social web: mugridgelab.orghttps://bsky.app/profile/mugridgelab.bsky.socialhttps://bsky.app/profile/mugridgelab.bsky.social/post/3mqa4pxyeh22zLots of turnover in the lab over the past academic year! Brittany Shimanski and Luke Calzini both finished PhDs (the 3rd + 4th PhDs from the lab)! Each did nice work on the selectivity and regulation of RNA demethylases; read their preprints here: https://doi.org/10.1101/2025.05.06.652568 https://doi.org/10.1101/2025.05.09.65310009 Jul 2026 17:08 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3mqa4pxyeh22zhttps://bsky.app/profile/mugridgelab.bsky.social/post/3mq7tpuh6rs2zCongrats to Evan, Youmna, and all other other coauthors on the final version of our Elp3 paper published in Nature Communications! [contains quote post or other embedded content]09 Jul 2026 14:27 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3mq7tpuh6rs2zhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lfudzbvdek22Congrats to Angel on the final version of her TRMT1 / SARS-CoV-2 Mpro story, now published in eLife! Her work reveals the structural basis for how #SARS-CoV-2 impacts #tRNA modifications! #RNAsky #RNAbiology [contains quote post or other embedded content]16 Jan 2025 13:08 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lfudzbvdek22https://bsky.app/profile/mugridgelab.bsky.social/post/3lf3kq3y3zc2dBig milestones - this year we said goodbye to the first two PhD grads from our lab! Now Drs. Angel D'Oliviera and Evan Geissler!👩‍🎓👨‍🎓 🎉 We also started a new lab tradition - PhD swords! ⚔️ Pictured is Angel's engraved sword with her Mpro-TRMT1 structure!06 Jan 2025 16:32 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lf3kq3y3zc2dhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lf3j6um5fk2dWe've now migrated our lab news feed from X/twitter to Bluesky using @blueark.app! Content that could be migrated from X/twitter are all below this post; original posting dates appear as tags on the expanded posts.06 Jan 2025 16:04 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lf3j6um5fk2dhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex2ysiln52wThis week we said farewell to our amazing undergrad Sophie Olson! Sophie did fantastic work in our lab and is graduating with a BS in Biochemistry! Congrats!🎉 Next up, Sophie will be killing it in the Molecular, Cellular, & Integrative Biosciences PhD program @PennState!22 May 2024 15:43 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2ysiln52whttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex2yvabks23Congrats to lab members Celeste and Youmna, who both recently passed their PhD qualifying exams! 🎉👩‍🔬26 Apr 2024 16:36 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2yvabks23https://bsky.app/profile/mugridgelab.bsky.social/post/3lex2yxh7wb2eWe finally got out and celebrated our lab's recent NSF CAREER award today with a lab bowling and laser tag trip! Pew pew! 🔫🎳13 Apr 2024 00:58 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2yxh7wb2ehttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex2yz3uyk2fVery excited that the @NSF CAREER will fund our lab's projects studying mechanisms of really cool tRNA-modifying metalloenzymes starting this year! Huge thanks to Evan & Youmna who got awesome preliminary data for this proposal! We hope to share work from these projects soon! 😀14 Feb 2024 19:48 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2yz3uyk2fhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex2z2ogqk24Lab trivia night to celebrate the end of the semester!19 May 2023 13:08 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2z2ogqk24https://bsky.app/profile/mugridgelab.bsky.social/post/3lex2z4fty52wAnother award for Sophie! Huge congrats to her on winning the Quaesita Drake Scholarship, given to outstanding undergraduate biochemists, at the @ChemistryUD awards colloquium earlier this week! Go Sophie! And congrats to all the other amazing undergrads who won awards!18 May 2023 12:54 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2z4fty52whttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex2z6q45s24Our rockstar undergrad Sophie Olson took home the 2nd place biochemistry prize for her awesome research talk at the 86th annual ISCC conference recently hosted at @LVC. Way to go Sophie!20 Apr 2023 20:54 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2z6q45s24https://bsky.app/profile/mugridgelab.bsky.social/post/3lex2zaa2uz2iCheers to Kasun @thxhungryhippo on rocking his candidacy exam earlier today! We celebrated with some morning mimosas! 🍾🍊06 Apr 2023 20:36 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2zaa2uz2ihttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex2zbjx2x2mCongratulations to Kasun @thxhungryhippo from our lab for winning a @ChemistryUD Dyer award for excellence in teaching! 🎉🧑‍🏫 Congrats to the other Dyer award winners as well for contributing to great teaching and TAing the CBC department!23 Mar 2023 19:15 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2zbjx2x2mhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex2zeq7jp2mLab escape room trip! We had two successful escapes!01 Dec 2022 03:26 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex2zeq7jp2mhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3ciavqj2iCelebrating the end of Summer session and great work from undergrads Sophie and Joseph (purple arrows), who just completed their first summer of research, with some UDairy ice cream! (consumed ice cream not pictured)15 Aug 2022 19:54 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3ciavqj2ihttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3cjnk3z2hCongrats to @mugridgelab undergrad Sophie Olson, whose Summer research in our lab will be funded by a @ChemistryUD David Plastino Fellowship! Congrats to the other awardees & big thanks to Dave Plastino - we're excited to have Sophie joining us over the Summer! 📷 @BrianBahnson27 May 2022 14:03 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3cjnk3z2hhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3cl2v2u2hCongrats to @mugridgelab undergrad Jasmin Bioteau for winning the @ChemistryUD Merck Index Award this year! Way to go Jasmin! Congrats to all the other departmental awardees too! 📷 @lauren_genova27 May 2022 13:55 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3cl2v2u2hhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3cmnabj2mA very much needed updated lab photo! We have lots of new group members to welcome who've joined over the past few months... 1/16 May 2022 14:30 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3cmnabj2mhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3cod7if2eWrapping up a busy semester of candidacy exams in the group! Congrats to Luke!11 May 2022 01:27 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3cod7if2ehttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3cpt2n22f🍾Congrats to Brittany! Now all 3 of the lab's first members are officially PhD candidates!18 Feb 2022 18:05 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3cpt2n22fhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3csdams24🎉Congratulations to Evan on passing his candidacy exam! We had a chilly but fun celebration!🍾⛄️27 Jan 2022 14:32 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3csdams24https://bsky.app/profile/mugridgelab.bsky.social/post/3lex3ctofbv2w🥳 Congratulations to now-PhD-candidate Angel @biochemistAngel on being the first student from our lab to advance to candidacy! Great work!22 Dec 2021 20:14 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3ctofbv2whttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3cxaudz2aEnjoying the Fall weather with a lab mini-golfing trip!05 Nov 2021 14:01 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3cxaudz2ahttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3m4i77l2zLab canoeing trip at Lum's Pond! Great weather and great fun. We missed Evan and Emily, but will get out more soon!26 Jul 2021 13:53 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3m4i77l2zhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3m6fj4t2z📣Come do science with us!🧪🧬 We're actively recruiting a POSTDOC and/or RESEARCH TECH on NIH-funded projects to understand the function and structure of RNA-modifying enzymes! Research Tech job desc:...07 Jun 2021 15:11 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3m6fj4t2zhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3maltm52eBelated welcome to new PhD students Luke and Emily, who joined the team earlier this year!02 Jun 2021 14:11 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3maltm52ehttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3mfne332zWe're excited to be a part of this fantastic @NIH COBRE program at UD! Thanks to @FoxGroupUD for leading this effort! https://www.udel.edu/udaily/2020/november/biomedical-research-cobre-joseph-fox-infectious-disease-cancer/25 Nov 2020 20:24 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3mfne332zhttps://bsky.app/profile/mugridgelab.bsky.social/post/3lex3mh76r224Lots of fun participating in the annual CBI pumpkin carving contest with other @ChemistryUD and @UDengineering labs! Brittany led our lab's effort to an honorable mention!30 Oct 2020 19:17 +0000at://did:plc:xfdokkjd2epq7lbno64ilraq/app.bsky.feed.post/3lex3mh76r224