Glycan 3D database and toolbox for the reconstruction of glycoproteins from the RCSB PDB and EMBL-EBI AlphaFold repositories or own. Find us at https://glycoshape.org. Curated by head chef @elisafadda.bsky.social and sous chef @ojas-singh.bsky.socialhttps://bsky.app/profile/glycoshape.orghttps://bsky.app/profile/glycoshape.org/post/3mkarw43mfs2wDaily job count is quite high these days after the release of our case study 1 week ago and of the ReGlyco de novo Binder Design Filter notebook ⬇️ https://doi.org/10.64898/2026.04.16.718906 and res. therein So exciting to see a growing number of researcher including glycosylation in their studies! 🎉 #glycotime 🧪24 Apr 2026 14:56 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3mkarw43mfs2whttps://bsky.app/profile/glycoshape.org/post/3mjytriits226We are proud to be part of @elixiruknode.org as the @unisouthampton.bsky.social node, and to share our expertise in structural and computational glycoscience 🧪, together with our OA resources thought it. Check out the announcement below for more information ⬇️ 🥳 [contains quote post or other embedded content]21 Apr 2026 11:08 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3mjytriits226https://bsky.app/profile/glycoshape.org/post/3mjosnq2bm22uMost biologics are glycosylated and some of them heavily. In this “fresh off the press" #glycotime preprint we look into how a filter that accounts for glycosylation explicitly in 3D can help reduce lab costs and increase the efficiency of de novo binder design pipelines. Short 🧵 ⬇️ 1/7 [contains quote post or other embedded content]17 Apr 2026 11:21 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3mjosnq2bm22uhttps://bsky.app/profile/glycoshape.org/post/3mibrmik4u22uSuper congratulations to the Siglec (and many other stories) extraordinaire Dr. D'Andrea!!! 👩‍🎓🎉🥂🍾 A huge thank you to the fantastic examiners Alba Silipo (external) and Trinidad Velasco-Torrijos (internal) for your expert and in-depth examination, which made Silvia's viva a great day to remember 😎30 Mar 2026 13:33 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3mibrmik4u22uhttps://bsky.app/profile/glycoshape.org/post/3mhgjemlsas2qSuper congratulation to Dr Akash Satheesan from the glycoShape team, who graduated officially today with a PhD @maynoothuniversity.ie !! 😎🎓👏🥳🥂 The 🔺-red gown definitely suits you well Akash! 😍19 Mar 2026 17:23 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3mhgjemlsas2qhttps://bsky.app/profile/glycoshape.org/post/3mg3roansjs26Lectins are known to be low affinity binders with relatively broad glycan target preference. In this work live in @commsbio.nature.com we show how Siglecs change this paradigm, acting as molecular precision tools required to fine tune immune response 🤯 #glycotime 🧵⬇️ https://doi.org/10.1038/s42003-026-09609-802 Mar 2026 17:27 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3mg3roansjs26https://bsky.app/profile/glycoshape.org/post/3mcht6ehwos26Phenomenal #glycotime by Lorenzo Rossi, @j-a-n-alexander.bsky.social, @asramirez.bsky.social and Kaspar Locher ⬇️ shows a pipeline for building THE glycoform you want with unprecedented yields! Now you can design your glycoform with GlycoShape and make it with Glyco-BUILD 👏 https://doi.org/10.1038/s41467-025-67055-215 Jan 2026 14:46 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3mcht6ehwos26https://bsky.app/profile/glycoshape.org/post/3mbk6rgvgwk2mHappy new year 2026 #glycotime! 🥳 We just introduced some useful options to Re-Glyco Ensemble. In the Advanced Settings you can now select a seed (positive integer) to reproduce structural ensemble of your favourite glycoforms such as the one below that you will see soon in an upcoming paper,03 Jan 2026 19:53 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3mbk6rgvgwk2mhttps://bsky.app/profile/glycoshape.org/post/3m7zgsfluuc2qHappy birthday to us! 🥂🎂🥳 We are only 2 yo, but so much #glycotime happened since Dec 2023! ⬇️🧵 We truly appreciate your support, you fabulous glycoengineers around the world and we have so many exciting new tools for you coming up in 2026 to make your 3D glycoforms even better and faster! 🤩15 Dec 2025 10:36 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m7zgsfluuc2qhttps://bsky.app/profile/glycoshape.org/post/3m7pi4yr3hc2cSuper interesting work from @carolynbertozzi.bskyverified.social group about the effects of glycosylation in protein structure and function at the proteome scale 🤯💥🤩 Results show that sialylation and fucosylation are crucial, which makes a lot of sense. We did some extra bits 🧐 with GlycoShape ⬇️🧵 [contains quote post or other embedded content]11 Dec 2025 11:34 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m7pi4yr3hc2chttps://bsky.app/profile/glycoshape.org/post/3m7ai3uexz22oWe just did some maintenance and updates to glycoshape.org, ✅ Fancy background with floating SNFG symbols 🤩 ✅ 'Latest Updates' feed from this account on bsky 🤩 ✅ Download PDB with SASA values in Re-Glyco Ensemble 🤩 Check it out!05 Dec 2025 12:23 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m7ai3uexz22ohttps://bsky.app/profile/glycoshape.org/post/3m76neydy722oFor some unique #glycotime: C-man is a rare (but evolutionarily very old[1]) post translational modification of proteins, where the C2 of Trp in W-x-x-W/C sequons are linked to a single man through a C-C bond 🤯 This and its position within the structure stabilises the (unusual for man) 1C4 chair[2]04 Dec 2025 18:52 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m76neydy722ohttps://bsky.app/profile/glycoshape.org/post/3m6zi63ilvs23Tuesday #glycotime 🥄🍬 Glycans are a 🔝 example of "disordered" molecules. Inherent flexibility prevents sugars from adopting fixed, unique 3D positions relative to the crystal lattice, so they often are invisible to X-ray diffraction, unless they are bound and thus restrained in place 1/3 🧵02 Dec 2025 17:36 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m6zi63ilvs23https://bsky.app/profile/glycoshape.org/post/3m6wxhyl45224Today we are attending the @biochemsoc.bsky.social International Glycoimmunology Online Symposium, enjoying brilliant talks and discussions around the key role of glycans in regulating our immune system in health and disease Phenomenal #glycotime 👏👏🤩 https://media.tenor.com/rReKAT-J3nsAAAAC/mind-blown-boom.gif?hh=371&ww=49801 Dec 2025 17:32 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m6wxhyl45224https://bsky.app/profile/glycoshape.org/post/3m6plf5qa3c24It's Fucose Friday 🔺, the best #glycotime of the week! Fucose is commonly found as a glycan modification, but it can be linked directly to proteins as O-fucose 😎 Here ⬇️ O-fucosylation of TSR1 by POFUT2 in the ER stabilises the TSRs characteristic fold 🤩 https://pmc.ncbi.nlm.nih.gov/articles/PMC9198472/28 Nov 2025 19:07 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m6plf5qa3c24https://bsky.app/profile/glycoshape.org/post/3m6mxxbxsfk24To wish our friend and main O-glycan 3D structure contributor extraordinaire @silviadandrea.bsky.social all the best with the submission of her PhD thesis tomorrow, today's 🥄🍬 is dedicated to sialic acid 💜 with a mini 🧵 about all the wonderful functions Silvia worked on27 Nov 2025 18:14 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m6mxxbxsfk24https://bsky.app/profile/glycoshape.org/post/3m6k6aasajc2fToday we used Re-Glyco to rebuild human EPO from AF-P01588 with glycosylation selected from Lippold et al [10.1021/acs.analchem.0c01794] From the 3D structure we identified ideal locations for extra N-glycans, some of which are actually in NESP [10.1054/bjoc.2001.1746] Super fun 3D edu #glycotime!26 Nov 2025 15:28 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m6k6aasajc2fhttps://bsky.app/profile/glycoshape.org/post/3m6gy65lcic2mTo welcome our new friends, first spoonful of sugar 🥄🍬 Glycan structures can be very complex and deceivingly similar, yet they have unique GlyTouCan IDs[1] that you can find by drawing the glycan you need in gb.glytoucan.org or in the glycoshape.org sugar drawer 1/3 🧵25 Nov 2025 09:01 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m6gy65lcic2mhttps://bsky.app/profile/glycoshape.org/post/3m6fbukd44c24Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news! We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬 We'll have great new tools coming up soon, so follow us for some exciting #glycotime https://media.tenor.com/fz7UYvCcubwAAAAC/grogu-star-wars.gif?hh=281&ww=49824 Nov 2025 16:50 +0000at://did:plc:xorrvcukxonsyeoudfzmnmhz/app.bsky.feed.post/3m6fbukd44c24