Research Associate at Reich lab @HarvardMed and @HarvardHEBhttps://bsky.app/profile/aliakbari.bsky.socialhttps://bsky.app/profile/aliakbari.bsky.social/post/3lp3dnt2vw223J-PEP is a new method that clusters disease-associated loci by combining pleiotropic SNP effects with tissue-specific epigenomic data. It improves biological resolution across complex traits. https://doi.org/10.1101/2025.05.05.2532701713 May 2025 20:37 +0000at://did:plc:yftiwnrtjaagsbm4qasptbys/app.bsky.feed.post/3lp3dnt2vw223https://bsky.app/profile/aliakbari.bsky.social/post/3ljmfw5u53c2aHow selection can incorporate evolutionary history into the genetic architecture of a single cell, giving rise to a hypermutable locus that appears to anticipate environmental change, thereby accelerating adaptive evolution. https://www.science.org/doi/10.1126/science.adr275605 Mar 2025 07:02 +0000at://did:plc:yftiwnrtjaagsbm4qasptbys/app.bsky.feed.post/3ljmfw5u53c2ahttps://bsky.app/profile/aliakbari.bsky.social/post/3lilo4dpm2s26Insufficient evidence for natural selection associated with the Black Death These claims are unsupported for four reasons... Finally, we find no evidence of significant change in frequency of the ERAP2 variant rs2549794... https://www.nature.com/articles/s41586-024-08496-520 Feb 2025 06:31 +0000at://did:plc:yftiwnrtjaagsbm4qasptbys/app.bsky.feed.post/3lilo4dpm2s26