APPRIS database and webserver updates, announcements and new releases. APPRIS: https://appris.bioinfo.cnio.es/#/https://bsky.app/profile/appris.bsky.socialhttps://bsky.app/profile/appris.bsky.social/post/3m7zwkvdhf22sUnless you use APPRIS principal isoforms, of course, where this can't happen. [contains quote post or other embedded content]15 Dec 2025 15:19 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3m7zwkvdhf22shttps://bsky.app/profile/appris.bsky.social/post/3m73d25miuk2oHas APPRIS selected the wrong principal isoform? Send us an email via the adresses on the website and we will investigate.03 Dec 2025 11:09 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3m73d25miuk2ohttps://bsky.app/profile/appris.bsky.social/post/3m3aftmueyk2wWe have recalculated APPRIS principal isoforms for GENCODE v48 / Ensembl 114 human. GENCODE added loss of function genes to this version and we discovered that this caused the TRIFID scores to change, affecting some of the PRINCIPAL:2 -> PRINCIPAL:5 isoforms. Our fault, we asked for the change!15 Oct 2025 14:02 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3m3aftmueyk2whttps://bsky.app/profile/appris.bsky.social/post/3lrfzbgjtr22jWe have updated APPRIS to @gencodegenes.bsky.social v48/ @ensembl.bsky.social v114. New principal isoforms for human, mouse, rat, cow and fruit fly ( @flybase.bsky.social ). Principal isoforms for a total of 73 human genes have been updated manually.12 Jun 2025 13:21 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3lrfzbgjtr22jhttps://bsky.app/profile/appris.bsky.social/post/3liwdkskn7c2fUsers of APPRIS may have noticed that there is a new category of principal isoforms, Principal:M. These principal isoforms are exclusive to the human gene set and are principal isoforms that have been manually corrected. In GENCODE v47 there were 45 genes with Principal:M isoforms. Here is DCD:24 Feb 2025 12:21 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3liwdkskn7c2fhttps://bsky.app/profile/appris.bsky.social/post/3lgps4i2o2c2gNice try, Luka. But even in a sham election with the real opposition candidates in jail, that is still some way short. of the 99.86% of supported ClinVar pathogenic mutations that map to APPRIS principal isoforms ...27 Jan 2025 11:02 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3lgps4i2o2c2ghttps://bsky.app/profile/appris.bsky.social/post/3lgd6bhf5cs2gAPPRIS has updated to GENCODE v47 and mouse M36. Danio rerio has also been updated to Ensembl 113. in this release 80.7% of human coding genes have a PRINCIPAL:1 isoform. Also, we have begun the manual curation of principal isoforms. More soon. @gencodegenes.bsky.social @ensembl.bsky.social22 Jan 2025 10:35 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3lgd6bhf5cs2ghttps://bsky.app/profile/appris.bsky.social/post/3kwf7zpkutl2aAPPRIS has new annotations for GENCODE human v46 and mouse M35. The human reference set now has 16,483 genes with Principal:P1 isoforms and mouse has 18,782 genes. Agreement with MANE Select transcripts in human (no MANE Select in mouse) has risen slightly to 17,661 genes. appris.bioinfo.cnio.es#/ https://appris.bioinfo.cnio.es/#/03 Jul 2024 15:29 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3kwf7zpkutl2ahttps://bsky.app/profile/appris.bsky.social/post/3kwex7pt2g52aAPPRIS in use ... [contains quote post or other embedded content]03 Jul 2024 12:51 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3kwex7pt2g52ahttps://bsky.app/profile/appris.bsky.social/post/3kolxo74lke2bAPPRIS has annotated principal and alternative isoforms and TRIFID functional isoform scores for Ensembl Bos taurus version e111: appris.bioinfo.cnio.es#/26 Mar 2024 12:27 +0000at://did:plc:ysv3irbsa2uryc6my5tyvu4k/app.bsky.feed.post/3kolxo74lke2b