The Human Protein Atlas (HPA) aims to map all human proteins in cells, tissues, and organs using integration of various omics technologies. The publicly available database contains millions of high-resolution images. www.proteinatlas.orghttps://bsky.app/profile/proteinatlas.bsky.socialhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mjjxzjregs2gA mIHC/IF panel is used to identify proteins expressed at specific stages of spermatogenesis. Here BEND2 is shown in the nucleus of cell state 2 spermatocytes (green) together with state 3 spermatocytes (magenta) and early (white) and late (red) spermatids. https://www.proteinatlas.org/news/2026-04-15/multiplex-tissue-image-of-the-month-bend2-in-testis15 Apr 2026 13:14 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mjjxzjregs2ghttps://bsky.app/profile/proteinatlas.bsky.social/post/3miyn2ffqkk2gIn the episode 102 of the Proteomics show podcast series, "All the parts", neuroscientist at Karolinska Institute and HPA researcher Jan Mulder talks about different aspects of the brain and brain research together with the hosts Benjamin Neely and Ben Orsburn. https://www.proteinatlas.org/news/2026-04-08/brain-talk-with-jan-mulder-in-the-proteomics-show-podcast08 Apr 2026 15:42 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3miyn2ffqkk2ghttps://bsky.app/profile/proteinatlas.bsky.social/post/3mijk7arvwc2zEaster celebration is very tightly linked to eggs and therefore we will take this opportunity to have a closer look at the zona pellucida proteins, some of the most important genes in the human oocyte. https://www.proteinatlas.org/news/2026-04-02/easter-gene-hunt02 Apr 2026 15:41 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mijk7arvwc2zhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mhx5xasbmc2mUsing mIHC/IF the adaptor protein SHC2 involved in cell signaling is shown in green in the cytoplasm of glucagon-producing alpha cells within the islets of Langerhans in pancreas . Other visualized cell types are beta cells (magenta) and delta cells (yellow). https://www.proteinatlas.org/news/2026-03-26/multiplex-tissue-image-of-the-month-shc2-in-pancreas26 Mar 2026 08:14 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mhx5xasbmc2mhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mhfs3papuk2mAt a recent high-level international meeting in Mexico City, 600 international delegated discussed trends in education, health and research. Mathias Uhlén shared a practical perspective on what universities must do as innovation cycles accelerate. https://www.proteinatlas.org/news/2026-03-19/bridging-science-and-industry-what-mathias-uhlacn-wants-the-next-generation-to-build19 Mar 2026 10:27 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mhfs3papuk2mhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mgu2vx47jk2xIn a study in J.Proteome Res >180 proteins have been spatially mapped to specific subcellular compartments in cells with motile cilia using multiplex IHC. The high-resolution data aids in further functional mapping of proteins with limited evidence. https://www.proteinatlas.org/news/2026-03-12/180-proteins-mapped-to-motile-ciliated-cells12 Mar 2026 09:17 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mgu2vx47jk2xhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mgcj3453vc2xA study in Science demonstrate that STING acts as a molecular barrier to bird flu and that a single substitution in the viral M1 protein leads to human IAVs evading activation of human STING, demonstrating the significance of this antiviral barrier for IAVs. https://www.proteinatlas.org/news/2026-03-05/sting-acts-as-a-molecular-barrier-to-bird-flu05 Mar 2026 09:42 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mgcj3453vc2xhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mfrptcevfc2xFebruary has been declared the gallbladder and bile duct cancer awareness month, and features the international World Cancer Day. This year's theme was "United by Unique" to raise awareness of the disease and request a cancer care more focusing on individuals. https://www.proteinatlas.org/news/2026-02-26/gallbladder-cancer-awareness-month26 Feb 2026 17:28 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mfrptcevfc2xhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mfca56fwc22zIn a report published in the Journal of Proteome Research last years advances and efforts within the HUPO coordinated Human Proteome Project (HPP) to define the human proteome and make proteomics an integral part of functional multiomics are presented. https://www.proteinatlas.org/news/2026-02-20/the-2025-hupo-hpp-report-on-the-human-proteome20 Feb 2026 13:37 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mfca56fwc22zhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mensoxpvrk2oThe spatial expression pattern of TMEM213 in ductal structures of the salivary gland, based on mIHC/IF, show localization (green) to the apical part of the membrane of large ducts (red) but not to small ducts (magenta) or serous acini (cyan). https://www.proteinatlas.org/news/2026-02-09/multiplex-tissue-image-of-the-month-tmem213-in-salivary-gland12 Feb 2026 10:43 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mensoxpvrk2ohttps://bsky.app/profile/proteinatlas.bsky.social/post/3me2ctuzj5c2oThe HPA primary cilia research by Hansen published in Cell has been recognized as setting a new standard for understanding ciliary function and its role in health and disease in a research highlight published in Nature Signal Transduction and Targeted Therapy. https://www.proteinatlas.org/news/2026-02-04/revisiting-primary-cilia04 Feb 2026 16:39 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3me2ctuzj5c2ohttps://bsky.app/profile/proteinatlas.bsky.social/post/3mdkjqadgzk2xDetection of cancer is challenging, especially since many common diffuse symptoms overlap with non-malignant conditions. In an article in Nat. Commun. plasma protein signatures was used to identify cancer among patients with non-specific symptoms. https://www.proteinatlas.org/news/2026-01-29/plasma-protein-profiling-predicts-cancer-in-patients-with-non-specific-symptoms29 Jan 2026 10:00 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mdkjqadgzk2xhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mcys7buhwc2uLysosomes play a central role in the controlled degradation crucial for cellular function and homeostasis. But what if the lysosomes themselves become damaged or dysfunctional? Recently a set of key players in the process called lysophagy was identified. https://www.proteinatlas.org/news/2026-01-22/lysophagy-degrading-the-degradation-factories22 Jan 2026 08:43 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mcys7buhwc2uhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mcfi3vcl4c2uCiliated cells are found in the endocervical epithelium in the inner canal of the cervix. Here the CAPSL gene is shown to be localized (green) to all of the annotated subcellular structures of the cervix ciliated cells except for the cilia basal body. https://www.proteinatlas.org/news/2026-01-14/multiplex-tissue-image-of-the-month-capsl-in-cervix14 Jan 2026 16:22 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mcfi3vcl4c2uhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mbeb6mt56s2lInsulin (green) is explored in endocrine pancreas using mIHC/IF and five peptide hormone markers specifically secreted by specialized endocrine cell types, including alpha cells (cyan) and delta cells (yellow) within the islets of Langerhans. https://www.proteinatlas.org/news/2025-12-31/multiplex-tissue-image-of-the-month-ins-in-pancreas01 Jan 2026 11:20 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mbeb6mt56s2lhttps://bsky.app/profile/proteinatlas.bsky.social/post/3ma6oy7tbmc2kIn PNAS researchers have used a combinatorial protein library to select binders against the cancer receptor EGFR that allow for selection of calcium -and pH dependency, an approach that can generate fine-tuned binders and possibly enable new treatment regimes. https://www.proteinatlas.org/news/2025-12-17/calcium-regulated-affinity-protein-for-efficient-internalization-and-lysosomal-toxin-delivery17 Dec 2025 12:46 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3ma6oy7tbmc2khttps://bsky.app/profile/proteinatlas.bsky.social/post/3m7psqtxhkk2kThis year's Nobel Prize in Physiology and Medicine was awarded discoveries concerning peripheral immune tolerance and regulatory T cells. These immune cells play an important role in protecting us from autoimmune diseases and FOXP3 is key to their function. https://www.proteinatlas.org/news/2025-12-11/nobel-prize-winning-foxp3-in-the-spotlight11 Dec 2025 14:44 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m7psqtxhkk2khttps://bsky.app/profile/proteinatlas.bsky.social/post/3m762yhth4s2kIn an article in Genetic Engineering and Biotechnology News, Gustav Ceder shares his impressions from the HUPO world congress in Toronto and the thoughts and perspectives from some of the big players in the proteomics field. https://www.proteinatlas.org/news/2025-12-04/what-sparked-excitement-at-hupo-202504 Dec 2025 13:23 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m762yhth4s2khttps://bsky.app/profile/proteinatlas.bsky.social/post/3m6k2qobjoc23At the HUPO meeting in Toronto HPA members contributed more than 25 talks and posters. Loren Méar was selected as a poster competition finalist for her work "Spatial proteomics uncovers structural and molecular complexity of the human ovary in 2D and 3D." https://www.proteinatlas.org/news/2025-11-26/hpa-poster-selected-finalist-at-hupo-mapping-the-hidden-architecture-of-the-human-ovary-in-3d26 Nov 2025 14:26 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m6k2qobjoc23https://bsky.app/profile/proteinatlas.bsky.social/post/3m62lvb7an224Specific expression of largely uncharacterized protein TMEM52B (green) in the apical part of the cytoplasm of distal tubular cells (red) highlighted with multiplex immunohistochemistry. Other visualized kidney structures include the proximal tubules (white). https://www.proteinatlas.org/news/2025-11-11/multiplex-tissue-image-of-the-month-tmem52b-in-kidney20 Nov 2025 10:50 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m62lvb7an224https://bsky.app/profile/proteinatlas.bsky.social/post/3m5eazdzplk2zVersion 25 of the Human Protein Atlas is launched. New additions are Olink Explore HT and SomaScan data for 32 cohorts including diseases and childhood development, more single cell data with 4 new tissues and 23000 predicted structures for protein interactions https://www.proteinatlas.org/news/2025-11-11/a-new-version-25-of-the-human-protein-atlas-has-been-released-at-the-hupo-meeting-in-toronto-canada11 Nov 2025 13:37 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m5eazdzplk2zhttps://bsky.app/profile/proteinatlas.bsky.social/post/3m4ztofs5fc2zIt is Movember and prostate cancer is in the spotlight. Explore prognostic genes associated with survival based on transcriptomics data and find out more about prostate cancer gene expression and cell line models in the Human Protein Atlas Cancer resource. https://www.proteinatlas.org/news/2025-11-07/movember-prostate-cancer-in-the-spotlight07 Nov 2025 10:11 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m4ztofs5fc2zhttps://bsky.app/profile/proteinatlas.bsky.social/post/3m4fjaqb2t22aAn article in PNAS investigates factors influencing recombinant protein expression in CHO cells showing that transgene mRNA abundance is not important, while MW, disulfide bonds, cysteine composition and N-linked glycosylation have the strongest effect. https://www.proteinatlas.org/news/2025-10-30/deciphering-the-determinants-of-recombinant-protein-expression-across-the-human-secretome30 Oct 2025 08:11 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m4fjaqb2t22ahttps://bsky.app/profile/proteinatlas.bsky.social/post/3m46r36tvuc2aJoin our project “Embedding Multimodal Data in a Vector Database to Build a Blood Atlas” remotely for the BioHackathon Europé 2025! Join the project kick-off meeting October 28 at 16:00 CET. Passcode: B8GwzS https://us05web.zoom.us/j/4205147624?pwd=bENwc3F2MTdKNzVUUk5qUEhuSGYrQT0927 Oct 2025 15:43 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m46r36tvuc2ahttps://bsky.app/profile/proteinatlas.bsky.social/post/3m3rqjldkik2aA study in Nat. commun. added OPTN as a player in the Golgi membrane-associated degradation GOMED. In HPA this ubiquitin-binding adaptor protein localize in a punctate pattern in the perinuclear region of the cytoplasm where also the Golgi apparatus resides. https://www.proteinatlas.org/news/2025-10-22/optineurin-as-a-key-player-in-gomed22 Oct 2025 11:28 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m3rqjldkik2ahttps://bsky.app/profile/proteinatlas.bsky.social/post/3m3ac6uwhdk2aCYLC1 a cytoskeletal protein associated with the 'head' structure of the sperm is visualized in late stage spermatogenesis with mIHC/IF and shown to be mainly localized (green) to the cytoplasm of cell state 2 (red) and 3 (white) of late spermatids. https://www.proteinatlas.org/news/2025-10-15/multiplex-tissue-image-of-the-month-cylc1-in-testis15 Oct 2025 12:57 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m3ac6uwhdk2ahttps://bsky.app/profile/proteinatlas.bsky.social/post/3m2rs7q4sas2wIn a study in Science, an international team of researchers have mapped how thousands of proteins in human blood shift as a result of aging and diseases. The molecular "fingerprints" from 59 diseases can enable blood tests to discern troubling signs from common. https://www.proteinatlas.org/news/2025-10-09/pan-disease-atlas-maps-molecular-fingerprints-of-health-disease-and-aging09 Oct 2025 18:33 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3m2rs7q4sas2whttps://bsky.app/profile/proteinatlas.bsky.social/post/3lzofuzxyp22eIn the journal Cell a deep analysis of the HPA primary cilia section is published. The primary cilia is portrayed as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, inspiring new views on this tiny antenna. https://www.proteinatlas.org/news/2025-09-25/human-protein-atlas-study-on-primary-cilia-published-in-cell25 Sep 2025 16:50 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3lzofuzxyp22ehttps://bsky.app/profile/proteinatlas.bsky.social/post/3lyzgz773kc2pTranscription factors SP5 and SP8 were recently shown to regulate primary cilia formation during embryogenesis. In the HPA subcellular resource they localize to the nucleus of human cell lines. https://www.proteinatlas.org/news/2025-09-17/transcription-factors-sp5-and-sp8-regulate-primary-cilia-formation-during-embryogenesis17 Sep 2025 08:44 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3lyzgz773kc2phttps://bsky.app/profile/proteinatlas.bsky.social/post/3lyiccxccqc2jIn a publication in PLOS One a deep learning model was successfully used to segment epithelial cells and identify invasive epithelial cells in tissue sections from breast cancer patients using IHC stainings as ground truth. https://www.proteinatlas.org/news/2025-09-10/immunohistochemistry-guided-segmentation-of-epithelial-cells-in-breast-cancer-slides10 Sep 2025 13:05 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3lyiccxccqc2j