The Human Protein Atlas (HPA) aims to map all human proteins in cells, tissues, and organs using integration of various omics technologies. The publicly available database contains millions of high-resolution images. www.proteinatlas.orghttps://bsky.app/profile/proteinatlas.bsky.socialhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mvqbz7ik7k2yThe protein FATE1 is abnormally expressed in many cancer types and using mIHC/IF it is shown to localize (green) to the cytoplasm (red) and nucleus (magenta) of Sertoli cells that support the developing sperm cells within the seminiferous ducts of testis. https://www.proteinatlas.org/news/2026-09-17/multiplex-tissue-image-of-the-month-fate1-in-testis17 Sep 2026 18:31 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mvqbz7ik7k2yhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mv5nuozzg22bThe expression of PDX1, the transcription factor regulating the embryonic development of the pancreas and expression of insulin in beta cells in the islets of Langerhans, is shown to localize (green) to the nucleus of beta cells (magenta) using mIHC/IF. https://www.proteinatlas.org/news/2026-09-10/multiplex-tissue-image-of-the-month-pdx1-in-pancreas10 Sep 2026 08:43 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mv5nuozzg22bhttps://bsky.app/profile/proteinatlas.bsky.social/post/3muox57e6zs2xCurrent therapies inadequately target T-cell pathways in autoimmune and inflammatory diseases limiting durable disease control. In a recent publication a novel, targetable transcriptional-metabolic axis that sustains inflammatory T-cell responses is identified. https://www.proteinatlas.org/news/2026-09-02/reducing-uncertainty-in-drug-development-a-q-a-with-thomas-helleday04 Sep 2026 12:19 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3muox57e6zs2xhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mu2xns2pss2xA Protein Science article presents the HPA Multiplex tissue resource, with 1,106 proteins analyzed across eight antibody panels. Mapping proteins to cell types, cell states, and tissue structures give deeper insights in protein expression in human tissues. https://www.proteinatlas.org/news/2026-08-27/the-multiplex-tissue-resource-provides-deeper-spatial-insight-into-protein-expression27 Aug 2026 13:35 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mu2xns2pss2xhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mtiuwmq33c26A protein in the wrong place can be catastrophic ALS is associated with high morbidity and early mortality. Now it has turned out that redistribution of the protein TARDBP from the nucleus to the cytoplasm in multiple brain cell types is part of the process. https://www.proteinatlas.org/news/2026-08-20/a-protein-in-the-wrong-place-can-be-catastrophic20 Aug 2026 08:58 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mtiuwmq33c26https://bsky.app/profile/proteinatlas.bsky.social/post/3msxh46selc2uA recent study investigated early changes in ovarian cancer. In this interview Fabian Coscia and Mihnea-Paul Dragomir discuss how the team moved from spatial proteomics discovery to tissue-based validation using an antibody against DHCR7. https://www.proteinatlas.org/news/2026-08-13/from-spatial-proteomics-to-tissue-validation-dhcr7-in-early-ovarian-cancer13 Aug 2026 10:35 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3msxh46selc2uhttps://bsky.app/profile/proteinatlas.bsky.social/post/3msdskm3bis2nA study in PNAS describes how hypoxia and elimination of peroxisomes drives HCC dedifferentiation. RNF126 is identified as a hypoxia-inducible switch that determines peroxisomal fate and links the hypoxic microenvironment to loss of hepatocyte differentiation. https://www.proteinatlas.org/news/2026-08-04/rnf126-and-the-dedifferentiation-of-liver-cancer05 Aug 2026 15:07 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3msdskm3bis2nhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mrxcj7x4n22nSaliva is a combination of enzyme-rich secretions from serous acini and mucin-rich secretions from mucus acini. Using mIHC/IF the regulator of acinar cell functions, BHLHA15 (green) is shown in the nucleus of serous acini (cyan) within the salivary gland. https://www.proteinatlas.org/news/2026-07-31/multiplex-tissue-image-of-the-month-bhlha15-in-salivary-gland31 Jul 2026 15:48 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mrxcj7x4n22nhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mra5mhbez22cMitochondria go where they are needed Mitochondria do a lot more than ATP production. The positioning of mitochondria within cells is regulated and dynamic and their direct interactions with other organelles can regulate many cellular processes. Read more https://www.proteinatlas.org/news/2026-07-22/mitochondria-go-where-they-are-needed22 Jul 2026 10:49 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mra5mhbez22chttps://bsky.app/profile/proteinatlas.bsky.social/post/3mq4uaae4gc2cTranscription factor FOXJ1 (magenta) and chromatin regulator HMGN3 (green) display different nuclear staining in the fallopian tube. FOXJ1 stains a subset of the cells in the fallopian tube epithelium while HMGN3 shows a more general staining pattern. https://www.proteinatlas.org/news/2026-07-08/multiplex-tissue-image-of-the-month-foxj1-and-hmgn3-in-fallopian-tube08 Jul 2026 09:58 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mq4uaae4gc2chttps://bsky.app/profile/proteinatlas.bsky.social/post/3mpnpficjjc2hA study in Nature suggests ALDH18A1 and ferroptosis as a therapeutic target for cancer treatment. Inhibition of ALDH18A1 suppressed livercarcinogenesis through depletion of spermine (essential for cellular homeostasis) and activation of ferroptosis in HCC. https://www.proteinatlas.org/news/2026-07-02/aldh18a1-and-ferroptosis-as-a-therapeutic-target-for-cancer-treatment02 Jul 2026 09:21 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mpnpficjjc2hhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mp4ghv3uws2hIn this episode of Proteins Unfolded Evelina Sjöstedt, head of HPA Single cell analysis talks about the transcriptome in the context of the genome and proteome. She discusses her current research at The Human Protein Atlas and single cell transcriptomics. https://www.proteinatlas.org/news/2026-06-25/talking-transcriptomics25 Jun 2026 12:26 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mp4ghv3uws2hhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mokdnnh4gc2zIn the Episode 82 of of the Proteomics show podcast series "Alt Proteomics" HPA researcher Dr Cecilia Lindskog talks about the importance of proteomics data integration together with the hosts Benjamin Neely and Ben Orsburn. https://www.proteinatlas.org/news/2026-06-18/the-proteomics-show-with-cecilia-lindskog18 Jun 2026 07:48 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mokdnnh4gc2zhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mnwzj7vldk2zGlycolysis-associated enzyme PKLR highlighted in cytoplasm of proximal tubular cells (green) in the kidney using multiplex immunohistochemistry. Other highlighted kidney structures are Distal tubules (red), podocytes (yellow) and endothelial cells (magenta). https://www.proteinatlas.org/news/2026-06-10/multiplex-tissue-image-of-the-month-pklr-in-kidney10 Jun 2026 15:26 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mnwzj7vldk2zhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mmvzcc33522vIn version 25.1 of the Human Protein Atlas, a dataset based on Deep Visual Proteomics has been integrated in the Single Cell resource to provide mass-spectrometry based proteomics at an unprecedented resolution across cell types and tissues. https://www.proteinatlas.org/news/2026-05-28/hpa-integrates-cell-type-resolution-protein-data-based-on-deep-visual-proteomics28 May 2026 12:24 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mmvzcc33522vhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mmlhxtrsdc2wA study by HPA researchers in Nature Communications presents a high-resolution spatial map of proteins associated with motile cilia in the human fallopian tube, providing new insights into reproductive biology, infertility and cilia-related disease. https://www.proteinatlas.org/news/2026-05-22/new-spatial-map-sheds-light-on-cilia-proteins-in-the-human-fallopian-tube24 May 2026 07:48 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mmlhxtrsdc2whttps://bsky.app/profile/proteinatlas.bsky.social/post/3mlqdq6kaic2iThe Human Protein Atlas welcomes GeneTex’s recent announcement formalizing a collaborative relationship with the Human Protein Atlas. Collaborations with Atlas Antibodies, NCI-CPTC, Thermo Fisher Scientific, and Absea Biotech are also acknowledged. https://www.proteinatlas.org/news/2026-05-13/advancing-tissue-based-protein-data-through-antibody-collaborations13 May 2026 12:50 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mlqdq6kaic2ihttps://bsky.app/profile/proteinatlas.bsky.social/post/3ml6t5gty2c26The differences in blood protein levels during childhood and early adulthood were recently explored in an article published in Nature Communications, which highlighted the importance of accounting for age and sex when analysing protein levels in children. https://www.proteinatlas.org/news/2026-05-06/blood-protein-profiling-from-childhood-through-adolescence06 May 2026 13:38 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3ml6t5gty2c26https://bsky.app/profile/proteinatlas.bsky.social/post/3mknf7pzrds2n SON and SRRM2 are essential for forming nuclear speckles and in a study in Cell it was shown that their simultaneous depletion resulted in complete dissolution of speckles, disturbing 3D-genome organization and H3 isochore gene expression. https://www.proteinatlas.org/news/2026-04-29/the-evolution-of-nuclear-speckles29 Apr 2026 15:13 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mknf7pzrds2nhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mk5srxxc222nIn a review article published in Pharmacological reviews the current knowledge regarding structure, function, opportunities for therapeutic targeting and distribution in tissues and cells of human and mammalian aGPCRs is summarised. https://www.proteinatlas.org/news/2026-04-23/human-and-mammalian-agpcrs23 Apr 2026 10:34 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mk5srxxc222nhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mjjxzjregs2gA mIHC/IF panel is used to identify proteins expressed at specific stages of spermatogenesis. Here BEND2 is shown in the nucleus of cell state 2 spermatocytes (green) together with state 3 spermatocytes (magenta) and early (white) and late (red) spermatids. https://www.proteinatlas.org/news/2026-04-15/multiplex-tissue-image-of-the-month-bend2-in-testis15 Apr 2026 13:14 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mjjxzjregs2ghttps://bsky.app/profile/proteinatlas.bsky.social/post/3miyn2ffqkk2gIn the episode 102 of the Proteomics show podcast series, "All the parts", neuroscientist at Karolinska Institute and HPA researcher Jan Mulder talks about different aspects of the brain and brain research together with the hosts Benjamin Neely and Ben Orsburn. https://www.proteinatlas.org/news/2026-04-08/brain-talk-with-jan-mulder-in-the-proteomics-show-podcast08 Apr 2026 15:42 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3miyn2ffqkk2ghttps://bsky.app/profile/proteinatlas.bsky.social/post/3mijk7arvwc2zEaster celebration is very tightly linked to eggs and therefore we will take this opportunity to have a closer look at the zona pellucida proteins, some of the most important genes in the human oocyte. https://www.proteinatlas.org/news/2026-04-02/easter-gene-hunt02 Apr 2026 15:41 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mijk7arvwc2zhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mhx5xasbmc2mUsing mIHC/IF the adaptor protein SHC2 involved in cell signaling is shown in green in the cytoplasm of glucagon-producing alpha cells within the islets of Langerhans in pancreas . Other visualized cell types are beta cells (magenta) and delta cells (yellow). https://www.proteinatlas.org/news/2026-03-26/multiplex-tissue-image-of-the-month-shc2-in-pancreas26 Mar 2026 08:14 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mhx5xasbmc2mhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mhfs3papuk2mAt a recent high-level international meeting in Mexico City, 600 international delegated discussed trends in education, health and research. Mathias Uhlén shared a practical perspective on what universities must do as innovation cycles accelerate. https://www.proteinatlas.org/news/2026-03-19/bridging-science-and-industry-what-mathias-uhlacn-wants-the-next-generation-to-build19 Mar 2026 10:27 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mhfs3papuk2mhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mgu2vx47jk2xIn a study in J.Proteome Res >180 proteins have been spatially mapped to specific subcellular compartments in cells with motile cilia using multiplex IHC. The high-resolution data aids in further functional mapping of proteins with limited evidence. https://www.proteinatlas.org/news/2026-03-12/180-proteins-mapped-to-motile-ciliated-cells12 Mar 2026 09:17 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mgu2vx47jk2xhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mgcj3453vc2xA study in Science demonstrate that STING acts as a molecular barrier to bird flu and that a single substitution in the viral M1 protein leads to human IAVs evading activation of human STING, demonstrating the significance of this antiviral barrier for IAVs. https://www.proteinatlas.org/news/2026-03-05/sting-acts-as-a-molecular-barrier-to-bird-flu05 Mar 2026 09:42 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mgcj3453vc2xhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mfrptcevfc2xFebruary has been declared the gallbladder and bile duct cancer awareness month, and features the international World Cancer Day. This year's theme was "United by Unique" to raise awareness of the disease and request a cancer care more focusing on individuals. https://www.proteinatlas.org/news/2026-02-26/gallbladder-cancer-awareness-month26 Feb 2026 17:28 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mfrptcevfc2xhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mfca56fwc22zIn a report published in the Journal of Proteome Research last years advances and efforts within the HUPO coordinated Human Proteome Project (HPP) to define the human proteome and make proteomics an integral part of functional multiomics are presented. https://www.proteinatlas.org/news/2026-02-20/the-2025-hupo-hpp-report-on-the-human-proteome20 Feb 2026 13:37 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mfca56fwc22zhttps://bsky.app/profile/proteinatlas.bsky.social/post/3mensoxpvrk2oThe spatial expression pattern of TMEM213 in ductal structures of the salivary gland, based on mIHC/IF, show localization (green) to the apical part of the membrane of large ducts (red) but not to small ducts (magenta) or serous acini (cyan). https://www.proteinatlas.org/news/2026-02-09/multiplex-tissue-image-of-the-month-tmem213-in-salivary-gland12 Feb 2026 10:43 +0000at://did:plc:zbsc4bjxiilvutawk7u6tnwk/app.bsky.feed.post/3mensoxpvrk2o