Scientist. Frog hunter. Founder and Chief Executive of Structural Genomics Consortium.https://bsky.app/profile/aledmedwards.bsky.socialhttps://bsky.app/profile/aledmedwards.bsky.social/post/3me6nlmcv2c2aVery cool to be at an over-subscribed hands-on meeting organized by @chemicalprobes.org, GSK and @crick.ac.uk, at which trainees will be guided by experts to learn how to assess the quality of small molecule tools used in the literature. Dozens of Protacs will be assessed today.06 Feb 2026 10:02 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3me6nlmcv2c2ahttps://bsky.app/profile/aledmedwards.bsky.social/post/3mc4dgsg6qk2bSteve Kerr is an impressive individual. Wins with class, loses with class, and speaks the truth. https://m.youtube.com/watch?v=5tmXTLODTTg11 Jan 2026 01:05 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3mc4dgsg6qk2bhttps://bsky.app/profile/aledmedwards.bsky.social/post/3ma72glxu322iAfter two years of method development, it’s out. Pretty excited about this method, which not only expedites hit-finding, but also expedites hit verification. https://www.nature.com/articles/s41467-025-67403-217 Dec 2025 16:11 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3ma72glxu322ihttps://bsky.app/profile/aledmedwards.bsky.social/post/3m7g4kxnc3s2tI don’t read any scientific papers in which the authors use too many significant digits in their figures. It’s a strong proxy indicator of shoddy science and shoddy thinking. On the up side, it means I only need to read a few papers a week.07 Dec 2025 18:13 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3m7g4kxnc3s2thttps://bsky.app/profile/aledmedwards.bsky.social/post/3m52xnnuyek2zI moved to Canada from Wales as a young boy, grew up here, and stayed. A great place to live, raise a family, and do science. We’re a multicultural country of immigrants, and that’s not bad, it’s our superpower. Come explore for yourself! @uhnresearch.ca @utoronto.ca https://www.science.org/content/article/canada-s-new-budget-aims-lure-u-s-researchers-relocate07 Nov 2025 20:55 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3m52xnnuyek2zhttps://bsky.app/profile/aledmedwards.bsky.social/post/3m2evkbhhbc2nFeel good story of day. Went to outdoor movie night at granddaughter’s school yesterday in downtown Toronto. The children and parents comprised a rainbow of colours, speaking a Babel of languages. It was so joyful watching all the children run and play together. Canada has done something right.04 Oct 2025 15:28 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3m2evkbhhbc2nhttps://bsky.app/profile/aledmedwards.bsky.social/post/3lzt42agr5c2cIf anything, this analysis on “what would have happened if the NIH had spent 40% less over past years” underestimates the impact of NIH on innovation. The most valuable IP walks on two feet. And guess who paid for the training of many industry scientists? https://www.science.org/doi/10.1126/science.aeb156427 Sep 2025 13:37 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3lzt42agr5c2chttps://bsky.app/profile/aledmedwards.bsky.social/post/3lymzam4vo22sIn selecting an antibody to use for your experiment, you should look in the literature and find the one that one is most cited. NOT!12 Sep 2025 10:06 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3lymzam4vo22shttps://bsky.app/profile/aledmedwards.bsky.social/post/3ly6oq3zqmc22For the non-Canadians out there, one of our best just died. Ken Dryden was an athlete, scholar, public servant. Bill Bradley is the closest equivalent in the United States. Dryden was my childhood hero. You want to understand a lot about Canada, read his book “The Game”. https://www.cbc.ca/news/canada/ken-dryden-tributes-canada-hockey-1.762707306 Sep 2025 17:20 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3ly6oq3zqmc22https://bsky.app/profile/aledmedwards.bsky.social/post/3lunjzqn32s2mAfter 5 years of planning and pilot projects, Target2035, which aims to develop and share pharmacological probes for all human proteins by 2035, is coming out of stealth mode. Our Roadmap for accelerating small molecule hit discovery is now published. rdcu.be/exxi7 https://rdcu.be/exxi723 Jul 2025 17:25 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3lunjzqn32s2mhttps://bsky.app/profile/aledmedwards.bsky.social/post/3lt43g6iavs2gGroan…. [contains quote post or other embedded content]04 Jul 2025 01:23 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3lt43g6iavs2ghttps://bsky.app/profile/aledmedwards.bsky.social/post/3lsvk43rbas23Not a minute goes by over the past 60 years that I have regretted my parents’ decision to move us to Canada. A country that is, and has always been, great. Happy Canada Day to all! 🇨🇦01 Jul 2025 10:57 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3lsvk43rbas23https://bsky.app/profile/aledmedwards.bsky.social/post/3ls4o5mgeck2hThis is heartbreaking, and shame on Trump, Musk and Rubio. But given USAID and the US people did a huge public service by investing in the infrastructure to distribute medicine in Africa, why can’t Canada step up, leverage this, and fund some of the programs? https://www.nytimes.com/2025/06/21/opinion/waste-musk-trump.html21 Jun 2025 13:33 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3ls4o5mgeck2hhttps://bsky.app/profile/aledmedwards.bsky.social/post/3lred4oxlb22rJays. So hot right now. Jays. #BlueJays @torontobluejays.bsky.social11 Jun 2025 21:12 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3lred4oxlb22rhttps://bsky.app/profile/aledmedwards.bsky.social/post/3lqfgkfcrcs2aUnbelievable https://www.nytimes.com/2025/05/29/well/maha-report-citations.html30 May 2025 14:21 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3lqfgkfcrcs2ahttps://bsky.app/profile/aledmedwards.bsky.social/post/3lq6jjmdr2k2uThe United States has levied sanctions on Harvard but not on Russia. A curious set of values.27 May 2025 20:25 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3lq6jjmdr2k2uhttps://bsky.app/profile/aledmedwards.bsky.social/post/3loofz4lt4s2uWaiting for Trump to emerge08 May 2025 17:15 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3loofz4lt4s2uhttps://bsky.app/profile/aledmedwards.bsky.social/post/3lnnrqwdmls2zSantos sentenced to 7 years. His big mistake was not to storm the Capitol. https://www.cbc.ca/news/world/us-santos-prison-sentence-1.751855125 Apr 2025 17:47 +0000at://did:plc:zhw5c7ukblelpzdghfywpjo4/app.bsky.feed.post/3lnnrqwdmls2z