Sir Henry Wellcome Fellow | Oxford with Ivan Ahel & Harvard with Steve Gygi Molecular mechanisms of cysteine modifications | GlcNAc and ADP-ribose Previously: The Francis Crick Institute/Imperial College London (postdoc), University of Dundee (PhD)https://bsky.app/profile/andriigorelik.bsky.socialhttps://bsky.app/profile/andriigorelik.bsky.social/post/3mka7hb3wls2eFascinating findings by using a clever technique! [contains quote post or other embedded content]24 Apr 2026 09:26 +0000at://did:plc:ztc6sxtobl6bom7v7h3dt4ft/app.bsky.feed.post/3mka7hb3wls2ehttps://bsky.app/profile/andriigorelik.bsky.social/post/3mbw6hwibq22gCheck out our latest story on AHR and PARP7 (TIPARP) degradation by the ADP-ribose-targeting E3 ligase DTX2 in the first issue of 2026 @embojournal.org! https://link.springer.com/article/10.1038/s44318-025-00656-108 Jan 2026 14:20 +0000at://did:plc:ztc6sxtobl6bom7v7h3dt4ft/app.bsky.feed.post/3mbw6hwibq22ghttps://bsky.app/profile/andriigorelik.bsky.social/post/3m6yjkbe67k27In our latest study we show that ligand-activated transcription factor AHR (environmental sensor) is ADP-ribosylated by PARP7. This ADP-ribose mark is recognised by the E3 ubiquitin ligase DTX2 targeting AHR for proteasomal degradation, enabling cells to rapidly shut down AHR-mediated transcription. https://www.embopress.org/doi/full/10.1038/s44318-025-00656-102 Dec 2025 08:28 +0000at://did:plc:ztc6sxtobl6bom7v7h3dt4ft/app.bsky.feed.post/3m6yjkbe67k27https://bsky.app/profile/andriigorelik.bsky.social/post/3m2jsgzfff22qOut in @natcomms.nature.com: Cryo-EM structure of the pseudo-HAT-containing O-GlcNAcase! Especially exciting since multiple companies are developing O-GlcNAcase inhibitors for Alzheimer's disease (tau is O-GlcNAcylated). Glad to have a small contribution in this story. Congrats to all authors! https://www.nature.com/articles/s41467-025-63893-206 Oct 2025 14:16 +0000at://did:plc:ztc6sxtobl6bom7v7h3dt4ft/app.bsky.feed.post/3m2jsgzfff22qhttps://bsky.app/profile/andriigorelik.bsky.social/post/3lxhmw4clds2bHappy to share that my first-author paper from my postdoc at Imperial @imperialcollegeldn.bsky.social and The Francis Crick Institute @crick.ac.uk is now published in Cell Reports! https://www.sciencedirect.com/science/article/pii/S221112472500951928 Aug 2025 13:16 +0000at://did:plc:ztc6sxtobl6bom7v7h3dt4ft/app.bsky.feed.post/3lxhmw4clds2bhttps://bsky.app/profile/andriigorelik.bsky.social/post/3ltm5ke3mv22rAn amazing paper from van der Heden and Ahel groups! They use clever chemistry to identify RNF114 as a dual ADP-ribose-Ubiquitin reader involved in the DNA damage response! Congratulations to first authors Max, @chatrin-c.bsky.social and Rishov. Happy to have a small contribution in this story https://www.nature.com/articles/s41467-025-61111-710 Jul 2025 10:44 +0000at://did:plc:ztc6sxtobl6bom7v7h3dt4ft/app.bsky.feed.post/3ltm5ke3mv22r