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James Briscoe
jamesbriscoe.bsky.social
did:plc:n5osxqos2rlj4wpp2zw7qy4c
Key finding #1: Shh has an extracellular half-life ~1h. Turnover much faster than downstream gene expression dynamics, indicating morphogen gradient is continually renewed during patterning
Suggests Shh's effective diffusion rate: ~0.125 μm²/s, remarkably similar to Dpp/Wingless in Drosophila
2025-08-26T08:28:19.691Z