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Nature Computational Science
natcomputsci.nature.com
did:plc:nil4qmehyyilrz4hyyshvacx
📢Out now! @chaohou.bsky.social, @yshen.bsky.social and colleagues show that PLMs predict fitness best when outputs align with evolutionary patterns in homologs, with the peak performance occurring at moderate predicted sequence likelihoods. https://www.nature.com/articles/s43588-026-01010-z?utm_source=bluesky&utm_medium=social&utm_campaign=natcomputsci
🔓 rdcu.be/ftBgt
2026-07-13T16:10:51.864Z