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The Lewis Lab
peterlewislab.bsky.social
did:plc:2kirbxvnvj7rvtpaft5q3oyu
VEFS: the NBD is gone. RNA binding is rare (small red bubble). Most PRC2 is RNA-free, catalytically active, and binds both CpG and non-CpG sites.
Result: diffuse H3K27me3 that dilutes PRC1 away from its normal targets, disrupting gene silencing.
Read more in our preprint: tinyurl.com/4yrwftrn
2025-08-13T21:54:06.058Z